Primero, Ponce, Puerto Rico

The Ponce YMCA Building is a historic structure located in the municipality of Ponce, Puerto Rico. It is located at 7843 Calle Nazaret, Urbanizacion Santa Maria. The structure was listed in the National Register of Historic Places on 4 June 2012.

Parque Graciela Rivera is a small, but charming, passive park in Barrio Primero, Ponce, Puerto Rico, at the intersection of Calla Aurora and Calle Torre/Calle Azucena. It is flanked by the statue of a woman called "La Labradora" (The Reaper). The park was named after the Puerto Rican soprano singer Graciela Rivera.

The Primera Iglesia Metodista Unida de Ponce (English: First United Methodist Church of Ponce. Officially, Missionary Society of the Methodist Episcopal Church) was the first structure erected in Puerto Rico by the celebrated architect Antonin Nechodoma. Constructed in 1907, the building houses a Methodist congregation and is located on Villa street in Ponce, Puerto Rico, in the city's historic district. The structure was listed on the U.S. National Register of Historic Places on 29 October 1987.

The Miguel C. Godreau House (Spanish: Casa Miguel C. Godreau) is a historic residence located in the historic zone of the municipality of Ponce, Puerto Rico. The house was designed by architects Julio Conesa and Julio Morales and was built in 1919. It was listed in the National Register of Historic Places (NRHP) in 1986.

The Museo de Arqueología de la Pontificia Universidad Católica de Puerto Rico (Museum of Archaeology of the Pontifical Catholic University of Puerto Rico) is a museum of archaeology located at the Pontificia Universidad Católica de Puerto Rico (PUCPR) main campus on Avenida Las Américas in Ponce, Puerto Rico. The museum is an educational unit of the Pontifical Catholic University of Puerto Rico's Biblioteca Encarnación Valdés, the university's main library. It has a collection of more than 10,000 artifacts from the past civilizations of Puerto Rico, including Igneri, Pre-Taíno, and Taíno cultures. In addition to displaying its permanent and special exhibitions, the museum also guards numerous other artifacts which are currently not on display due to its space limitations.

The Museo del Autonomismo Puertorriqueño (English: Museum of Puerto Rican Autonomism) is a small museum in Ponce, Puerto Rico, that showcases the political history of Puerto Rico with an emphasis on the contributions made by the municipality of Ponce and its residents. The museum was established on 7 September 2006.

Museo de Arte de Ponce (MAP) is an art museum located on Avenida Las Américas in Ponce, Puerto Rico. It houses a collection of European art, as well as works by Puerto Rican artists. The museum contains one of the most important Pre-Raphaelite collections in the Western Hemisphere, holding some 4,500 pieces of art distributed among fourteen galleries.Museo de Arte de Ponce is the finest art museum in Puerto Rico. The largest art museum in the Caribbean, it has also been called one of the best in the Americas. It was the first museum in Puerto Rico accredited by the American Alliance of Museums.It was founded in 1959 by industrialist and philanthropist Luis A. Ferré at a location in the Ponce Historic Zone. The museum moved to its current building location on Avenida Las Américas in 1965. In 2010, the museum increased its size significantly after a $30M expansion.

The Escuela Hemeterio Colón y Warens (English: Hemeterio Colón y Warens School), also widely referred to as La Hemeterio or La Colón, is a public, intermediate school serving the city of Ponce, Puerto Rico. Its original, main building, built in 1913, is architecturally significant as a well-preserved example of the Puerto Rican school buildings of the early 20th century, a period of great transformation in Puerto Rico under the American administration. It was designed by insular architect Albert B. McCulloch using the California Mission Revival and Classical Revival styles, as well as some Modernist elements associated with the work of Antonin Nechodoma.The school was entered on the U.S. National Register of Historic Places in 2022.

The Centro Ponceño de Autismo (English: Ponce Autism Center), or CEPA, is the only center specialized in the diagnosis and treatment of autism in Puerto Rico. It is a non-profit organization. The center leads progressive research studies and medical training while providing comprehensive, personalized care to children and adults with Autism Spectrum Disorders (ASD), including Asperger's Disorder and PDD NOS. Working together with families, the Centro Ponceño de Autismo aims to identify the causes of autism and advance effective treatments. In 2011, it was reported that the Center cared for 179 patients.

Iglesia Santa María Reina is a Roman Catholic church in Barrio Canas Urbano, Ponce, Puerto Rico. A unique characteristic of the church is its vaulted roof.

The Rosaly–Batiz House (Spanish: Residencia Rosaly-Batiz) is a historic building located on Villa street in Barrio Primero in Ponce, Puerto Rico, in the city's historic district. The building dates from 1897. It was designed by Manuel V. Domenech, a Puerto Rican architect that was responsible for designing various other now-historic buildings. Domenech built this residence for Ponce mayor Pedro Juan Rosaly. Domenech himself became mayor of Ponce and held numerous other political positions in Puerto Rico. The Batiz Residence is a monument to a great man and his works and a vivid reminder of the aristocracy of the years prior to the Great Depression.

Colegio San Conrado is a private Catholic school in Ponce, Puerto Rico. It was founded in 1948 by the Capuchin Friars, under the direction of the Sisters of St. Joseph of Brentwood, New York. Currently the School is owned by the Diocese of Ponce and administered by the Sisters of Saint Joseph.