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Seneca (officially Merchants Insurance @ Seneca since June 27, 2019 for sponsorship purposes) is a Buffalo Metro Rail station located in the 200 block of Main Street between Seneca and Swan Streets in the Free Fare Zone, which allows passengers free travel between Erie Canal Harbor and Fountain Plaza station. Passengers continuing northbound past Fountain Plaza are required to provide proof-of-payment. On June 27, 2019, The Buffalo News announced that Merchants Insurance, which has been located at 260 Main Street since the 1960s, bought the naming rights for $161,000 for initially five years, with the option to renew for another five years.

Seneca One Tower is a skyscraper located in downtown Buffalo, New York. The building was formerly known as One HSBC Center (1999–2013) and prior to that, as Marine Midland Center (1972–1999), its name was changed in 1999 shortly after Marine Midland's parent company HSBC re-branded the bank as HSBC Bank USA. The building was constructed at a cost of $50 million between 1969 and 1974, and contains over 1,200,000 square feet (110,000 m2) of space. Today, the 40 story building still dominates the Buffalo skyline, at 529 feet (161 m) high. It is an example of modern architecture. The building's design is similar to that of the 33 South Sixth building in Minneapolis, reason being that both buildings were designed by the same architectural firm. In 2021, the entire tower and 4 mezzanine floors were finished being renovated as part of a $150 million renovation by Douglas Development, which included adding over 200 prime rate apartments.

The Fidelity Trust Building, also known as Swan Tower, is a 160,000-square-foot (15,000 m2) commercial Renaissance Revival office building located at 284 Main Street in the Joseph Ellicott Historical District (also called the Downtown Historic District) in downtown Buffalo, New York.

Sahlen Field is a baseball park in Buffalo, New York, United States. Originally known as Pilot Field, the venue has since been named Downtown Ballpark, North AmeriCare Park, Dunn Tire Park, and Coca-Cola Field. Home to the Buffalo Bisons of the International League, it opened on April 14, 1988 and can seat up to 16,600 people, making it the highest-capacity Triple-A ballpark in the United States. It replaced the Bisons' former home, War Memorial Stadium, where the team played from 1979 to 1987. The stadium was the first retro-classic ballpark built in the world, and was designed with plans for Major League Baseball (MLB) expansion. Buffalo had not had an MLB team since the Buffalo Blues played for the Federal League in 1915. However, Bisons owner Robert E. Rich Jr. was unsuccessful in his efforts to bring an MLB franchise to the stadium between 1988 and 1995. The stadium was a temporary home to the Toronto Blue Jays of MLB in 2020 and 2021 when they were displaced by the COVID-19 pandemic. Sahlen Field was previously home to the Buffalo Nighthawks of the Ladies Professional Baseball League in 1998, the Buffalo Bulls of the National Collegiate Athletic Association in 2000, and the Empire State Yankees of the International League in 2012. In addition to concerts and professional wrestling, the stadium has hosted major events including the National Old-Timers Baseball Classic (1988–1990), Triple-A All-Star Game (1988, 2012), StarGaze (1992–1993), World University Games (1993) and National Buffalo Wing Festival (2002–2019).

The Ellicott Square Building is a historic office complex, completed in 1896, located in Buffalo, New York.

St. Paul's Cathedral is the cathedral of the Episcopal Diocese of Western New York and a landmark of downtown Buffalo, New York. The church sits on a triangular lot bounded by Church St., Pearl St., Erie St., and Main St. It was built in 1849-51 to a design by Richard Upjohn, and was believed by him to be his finest work. Its interior was gutted by fire in 1888, and was redesigned thereafter by Robert W. Gibson, and it was designated a National Historic Landmark in 1987 for its architecture.

The Guaranty Building, formerly called the Prudential Building, is an early skyscraper in Buffalo, New York. It was designed by Louis Sullivan and Dankmar Adler and completed in 1896. The building has been declared a National Historic Landmark.

The Lehigh Valley Terminal was a railroad station in downtown Buffalo, New York. The Lehigh Valley Railroad opened it in 1916, replacing an older station one block east at Scott and Washington streets. Lehigh Valley trains served at the station included the Black Diamond, Maple Leaf and Star. The station handled the Lehigh Valley's passenger traffic in Buffalo until 1955, when it was demolished to make room for the Niagara Thruway (Interstate 190). The Lehigh Valley moved its operations to a smaller station outside the downtown area at Dingens and South Ogden Streets, which served until the end of all Lehigh Valley passenger service in 1961. The terminal also hosted the Erie Railroad's passenger trains from 1935 until 1951, when that railroad ceased serving Buffalo.

Church is a Buffalo Metro Rail station located in the 300 block of Main Street (just north of Church Street) in the Free Fare Zone, which allows passengers free travel between Erie Canal Harbor and Fountain Plaza. Passengers continuing northbound past Fountain Plaza are required to have proof-of-payment. Church is the closest to the Buffalo Metropolitan Transportation Center, located two blocks east at Ellicott and North Division Streets.

Buffalo Memorial Auditorium, colloquially known as The Aud, was a multipurpose indoor arena in downtown Buffalo, New York. Opened on October 14, 1940, it was home to the Canisius Golden Griffins (NCAA), the Buffalo Bisons (AHL), the Buffalo Bisons (NBL), the Buffalo Braves (NBA), the Buffalo Sabres (NHL), the Toronto-Buffalo Royals (WTT), the Buffalo Stallions (MSL), the Buffalo Bandits (MILL), the Buffalo Blizzard (NPSL) and the Buffalo Stampede (RHI). It also hosted events such as college basketball, concerts, professional wrestling and boxing. The venue was closed in 1996 after the construction of Marine Midland Arena, and remained vacant until being demolished in 2009.

Erie Canal Harbor (formerly Auditorium until September 1, 2003) is a Buffalo Metro Rail station located in the 100 block of Main Street (just north of Hanover and Scott Streets) next to the South Aud Block of Canalside in the Free Fare Zone, which allows passengers free travel between this station and Fountain Plaza station. Passengers continuing past Fountain Plaza are required to provide proof-of-payment. Unless there are events occurring at KeyBank Center, in which case Special Events station will be utilized, this is the southern terminus of Metro Rail. Since Erie Canal Harbor station serves as a terminal, immediately north is a double crossover. Erie Canal Harbor station is located close to Amtrak's Buffalo–Exchange Street station and the two stations are connected by a lit pathway beneath Interstate 190 with decorative cement and signage.

Saint Joseph Cathedral, is located at 50 Franklin Street, in downtown Buffalo, New York and is currently the cathedral church of the Roman Catholic Diocese of Buffalo.