Fidelity Trust Building

St. Paul's Cathedral is the cathedral of the Episcopal Diocese of Western New York and a landmark of downtown Buffalo, New York. The church sits on a triangular lot bounded by Church St., Pearl St., Erie St., and Main St. It was built in 1849-51 to a design by Richard Upjohn, and was believed by him to be his finest work. Its interior was gutted by fire in 1888, and was redesigned thereafter by Robert W. Gibson, and it was designated a National Historic Landmark in 1987 for its architecture.

The Ellicott Square Building is a historic office complex, completed in 1896, located in Buffalo, New York.

Seneca (officially Merchants Insurance @ Seneca since June 27, 2019 for sponsorship purposes) is a Buffalo Metro Rail station located in the 200 block of Main Street between Seneca and Swan Streets in the Free Fare Zone, which allows passengers free travel between Erie Canal Harbor and Fountain Plaza station. Passengers continuing northbound past Fountain Plaza are required to provide proof-of-payment. On June 27, 2019, The Buffalo News announced that Merchants Insurance, which has been located at 260 Main Street since the 1960s, bought the naming rights for $161,000 for initially five years, with the option to renew for another five years.

The Guaranty Building, formerly called the Prudential Building, is an early skyscraper in Buffalo, New York. It was designed by Louis Sullivan and Dankmar Adler and completed in 1896. The building has been declared a National Historic Landmark.

The Marin, previously the Main Seneca Building, and originally known as the Marine Midland Trust Company Building or the "Marine Trust Building," is a 17-story Renaissance Revival style highrise in downtown Buffalo, New York. The building was previously the headquarters for Marine Midland Bank before the bank constructed One Marine Midland Center at 1 Seneca Tower, the tallest building in Buffalo.

Church is a Buffalo Metro Rail station located in the 300 block of Main Street (just north of Church Street) in the Free Fare Zone, which allows passengers free travel between Erie Canal Harbor and Fountain Plaza. Passengers continuing northbound past Fountain Plaza are required to have proof-of-payment. Church is the closest to the Buffalo Metropolitan Transportation Center, located two blocks east at Ellicott and North Division Streets.

Sahlen Field is a baseball park in Buffalo, New York, United States. Originally known as Pilot Field, the venue has since been named Downtown Ballpark, North AmeriCare Park, Dunn Tire Park, and Coca-Cola Field. Home to the Buffalo Bisons of the International League, it opened on April 14, 1988 and can seat up to 16,600 people, making it the highest-capacity Triple-A ballpark in the United States. It replaced the Bisons' former home, War Memorial Stadium, where the team played from 1979 to 1987. The stadium was the first retro-classic ballpark built in the world, and was designed with plans for Major League Baseball (MLB) expansion. Buffalo had not had an MLB team since the Buffalo Blues played for the Federal League in 1915. However, Bisons owner Robert E. Rich Jr. was unsuccessful in his efforts to bring an MLB franchise to the stadium between 1988 and 1995. The stadium was a temporary home to the Toronto Blue Jays of MLB in 2020 and 2021 when they were displaced by the COVID-19 pandemic. Sahlen Field was previously home to the Buffalo Nighthawks of the Ladies Professional Baseball League in 1998, the Buffalo Bulls of the National Collegiate Athletic Association in 2000, and the Empire State Yankees of the International League in 2012. In addition to concerts and professional wrestling, the stadium has hosted major events including the National Old-Timers Baseball Classic (1988–1990), Triple-A All-Star Game (1988, 2012), StarGaze (1992–1993), World University Games (1993) and National Buffalo Wing Festival (2002–2019).

The Buffalo Veterans Treatment Court is a judicial "veterans' court" which was first established in 2008 in Buffalo, New York, USA, as part of the Erie County court system. The court, which bills itself as a "hybrid drug and mental health court", is considered the first of its kind in American law services, and was established in order to provide a civil court which tries cases involving veterans of the United States Armed Forces, based upon the belief that a large proportion of veterans from present and past conflicts have experienced hardships which are unique to their former service in the military. The current judge of the court is Justice Robert T. Russell.

The Edward A. Rath County Office Building is a high-rise office building located at 95 Franklin Street, in Buffalo, New York across from Erie County Hall and the Prudential (Guaranty) Building. The Rath building was named for Edward A. Rath, the first County Executive of Erie County, New York. The building contains the Erie County Executive’s office, Department of Motor Vehicles, Department of Public Works, the Office of Geographic Information Services, and a number of other county departments. It was designed by architectural firms Milstein, Wittek, Davis & Hamilton and Backus, Crane & Love, and constructed c. 1968.

The Main Place Tower is located at 350 Main Street, in Buffalo, NY. The skyscraper is the fourth-tallest building in the city, and home to many technology and communication firms. The tower, built in 1969, rises 350 feet (107 meters). The shopping center within the complex is referred to as the Main Place Mall.

One M&T Plaza is an office tower located in Buffalo, New York and home to M&T Bank in Erie County. The 21-story International style or New Formalist office tower was designed by Minoru Yamasaki with Duane Lyman Associates and completed in 1967. The structural steel for the building was produced locally by Bethlehem Steel, and was a product of their V50 grade. The base of the building is composed of white and green marble with an interior of travertine. The building also features a 75-by-225 foot exterior plaza.

Saint Joseph Cathedral, is located at 50 Franklin Street, in downtown Buffalo, New York and is currently the cathedral church of the Roman Catholic Diocese of Buffalo.