Magsaysay Boulevard

Santa Mesa station is a railway station located on the South Main Line in the city of Manila, Philippines. It is one of two stations (the other is Pasay Road) in the line to have its own access road. The station is the fourth station southbound from Tutuban and is the only railway station serving Santa Mesa. In addition to having its own dedicated access road, Santa Mesa station is also one of three stations (the others being Pasay Road and España) to have its original platforms extended and raised in order to accommodate new PNR diesel multiple units. The original platforms have been retained for the use of Commuter Express locomotives and especially for intercity trains, although Santa Mesa is not designated as a station where these trains can stop. The station used to serve the Santa Mesa-Mandaluyong branch line, also known as Guadalupe line, which used to run up to Antipolo and Montalban. This line has since been dismantled.

Sacred Heart of Jesus Catholic School (SHJCS) is a private Catholic school located in Santa Mesa, Manila, beside this is the Sacred Heart of Jesus Parish. The school's name is named after their parish patron, Sacred Heart of Jesus. The school was formerly known as Sta. Mesa Parochial School. The director of the school is the Rev. Fr. Marion C. Munda and the principal is Dr. Henry A. Davalos.

Pureza station is an elevated Light Rail Transit (LRT) station located on the LRT Line 2 (LRT-2) system in Santa Mesa, Manila. It is named because of its location on Pureza Street. The station is the third station for trains headed to Antipolo and the eleventh station for trains headed to Recto.

The Ninoy Aquino Library and Learning Resources Center (NALLRC) is the library system of the Polytechnic University of the Philippines composed of libraries providing services to the PUP System. Its headquarters is in the building of the same name, located in Manila, Philippines. NALLRC offers various services and development of programs to its clientele. The NALLRC Main Library is regarded as one of the largest libraries in Southeast Asia. The building is also home to the university's College of Law and Open University System.

The University Center for Culture and the Arts (UCCA) is a non-profit cultural center of the Polytechnic University of the Philippines. The agency is under the Office of the Vice President for Student Services. The UCCA is currently residing at the PUP Theater inside the PUP College of Communication compound. The UCCA hosts various events inside and outside the university. On August 29, 2014, the Polytechnic University of the Philippines through UCCA conferred the 'Pambansang Artista Ng Mamamayan' award to Nora Aunor in the PUP Theater. The UCCA also spearheads the annual university Arts Month every February.

The Polytechnic University of the Philippines College of Law, abbreviated as CL, is the law school of the Polytechnic University of the Philippines located in Manila, Philippines that was established in 2001. It ranks as one of the top law schools in the country in terms of percentile passing rate in the bar examination.

The PUPHAM-RCG INC formerly known as Polytechnic University of the Philippines Help, Assist, Mobilize - Radio Communications Group Incorporated (PUPHAM-RCG INC) is a non-profit university-based organization engaged in university and public service through radio communications.

The Apolinario Mabini Shrine (Filipino: Dambanang Apolinario Mabini) is a historic site in Santa Mesa, Manila, Philippines. It is noted for being the residence of Filipino military leader Apolinario Mabini who figured in the Philippine Revolution. Originally situated along the Nagtahan River, the structure was moved to the Polytechnic University of the Philippines main campus in Santa Mesa, Manila in the mid-2000s.

The Polytechnic University of the Philippines Laboratory High School (Filipino: Sanayang Mataas na Paaralan ng Politeknikong Unibersidad ng Pilipinas), abbreviated as PUPLHS, is the laboratory school of the Polytechnic University of the Philippines College of Education located in PUP Mabini Campus, Sta. Mesa, Manila. It was established in 1954 as the Philippine College of Commerce High School offering commercial courses, and is the first high school to offer commercial curriculum in the Philippines. The school has a student population of 541 in 2015.

Polytechnic University of the Philippines (PUP; Filipino: Politeknikong Unibersidad ng Pilipinas) is a research and coeducational state university in Manila, Philippines. It was founded on 19 October 1904, as the Manila Business School (MBS) and as part of Manila's public school system. It was eventually promoted to chartered state university in 1978, by virtue of Presidential Decree 1341. PUP has more than 20 campuses and extensions across Central Luzon, Southern Luzon and Metro Manila. With over 70,000 enrolled students, PUP claims to be the largest state university in the Philippines by student population. In 2013, PUP ranked 300+ in the QS Asia University Rankings. In the same year, the QS World University Rankings Country File on the Philippines also placed PUP third in Life Science and Medicine, fifth in Natural Science (Chemistry), fourth in Economics and Econometrics, and fifth in Communication and Media Studies. 58 PUP programs have been accredited by the Accrediting Agency of Chartered Colleges and Universities in the Philippines (AACCUP) while 2 (Journalism and Filipino) were granted Center of Development status by the Commission on Higher Education. A 2018 survey of 503 JobStreet employers ranked PUP as the top choice of employers in general, the top choice in the business process outsourcing (BPO) industry, and the second choice in the Manufacturing, IT, and Banking industries. The Universal Access to Quality Tertiary Education Act of 2017 mandates free tuition and fees for all students of state universities and colleges. Before the act was enforced, the tuition was exactly ₱12 (roughly 24 US cents) per unit (Since 1979) for undergraduate students. Students may opt out of the subsidy and choose to pay the full tuition instead. PUP has a reputation for student activism against tuition fee hikes.PUP's athletic team is known as the Mighty Maroons and plays in the National Capital Region Conference of the State Colleges and Universities Athletic Association (SCUAA). The team also played in the National Athletic Association of Schools, Colleges and Universities (NAASCU) in 2013. Its official volleyball team, the PUP Lady Radicals, played in the Shakey's V-League in 2015.

Sampaloc is a district of Manila, Philippines. It is referred to as the University Belt or simply called "U-Belt" for numerous colleges and universities are found within the district such as the University of Santo Tomas, the oldest extant university in Asia; the National University, the first private nonsectarian and coeducational institution in the Philippines; the Far Eastern University, known for its Art Deco campus and cultural heritage site of the Philippines; and the University of the East, once dubbed as the largest university in Asia in terms of enrollment. The district is bordered by the districts of Quiapo and San Miguel in the south, Santa Mesa district in the south and east, Santa Cruz district in the west and north, and Quezon City in the northeast. Aside from being the "University Belt", Sampaloc is also known to Metro Manila and the surrounding provinces for its Dangwa flower market, located in Dimasalang Road, well known as the selling center for cut flowers from all over the Philippines, mainly Baguio. Sampaloc is also the location of a former colonial mansion, now called Windsor Inn, which is popular among backpackers and budget travelers. Barangays 395 to 636 of the City of Manila would all have belonged to Sampaloc and comprise 241 barangays for the district. However, what are now known as barangays 587-636 became part of Santa Mesa when these areas were separated from Sampaloc after Santa Mesa became a separate parish in 1911. Santa Mesa is now a part of the 6th congressional district of Manila, while Sampaloc is the sole district comprising the 4th congressional district of Manila. Many streets in Sampaloc, particularly in the northeast portion divided by España and Lacson Avenues, have names that are directly associated with the Philippine national hero José Rizal, either named after the places (e.g. Calamba, Dapitan), real-life people (e.g. Blumentritt), characters from his novels (e.g. Ibarra, Maria Clara) or his pen names (e.g. Laong Laan, Dimasalang).

The Battle of Manila (Filipino: Labanan sa Maynila; Spanish: Batalla de Manila), the first and largest battle of the Philippine–American War, was fought on February 4–5, 1899, between 19,000 American soldiers and 15,000 Filipino armed militiamen. Armed conflict broke out when American troops, under orders to turn away insurgents from their encampment, fired upon an encroaching group of Filipinos. Philippine President Emilio Aguinaldo attempted to broker a ceasefire, but American General Elwell Stephen Otis rejected it and fighting escalated the next day. It ended in an American victory, although minor skirmishes continued for several days afterward.