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West Catholic Preparatory High School is a co-educational Catholic high school in the Archdiocese of Philadelphia. It is located in Philadelphia, Pennsylvania, at 45th and Chestnut Streets, the University City neighborhood of West Philadelphia.

46th Street station is an elevated SEPTA rapid transit station in Philadelphia, Pennsylvania. It is located above the intersection of Farragut, 46th, and Market Streets in the Mill Creek and Walnut Hill neighborhoods of West Philadelphia, and serves the Market-Frankford Line. The station is also served by SEPTA bus routes 31 and 64.

Spruce Hill is a neighborhood in the University City section of West Philadelphia. It is between 40th and 46th streets, and it stretches from Market Street south to Woodland Avenue. With a population of over 16,000, it is a racially and ethnically diverse part of the city where much historic architecture is preserved. The neighborhood contains a large number of Victorian rowhouses, many of which have been converted to multi-family apartments.It was built as a streetcar suburb for Center City between 1850 and 1910. Among its most prominent developers was financier Clarence Howard Clark Sr. (1833 – 1906), who built dozens of rowhouses, donated land for the Walnut Street West Branch of the Free Library of Philadelphia, settled a tax assessment by founding the 9.1-acre Clark Park, and established his mansion on the grassy block that today holds the Penn Alexander public elementary school. A statue of Charles Dickens, cast in 1890 by Francis Edwin Elwell, stands in Clark Park; it is one of just two known statues of the author.

The Drexel Dragons are the athletic teams of Drexel University in Philadelphia, Pennsylvania. The school's athletic program includes eighteen NCAA Division I sports including nine men's and nine women's teams, with most sports teams competing in the Colonial Athletic Association (CAA). Drexel's athletic department was ranked first in gender equity by U.S. News. The university has demonstrated a high level of student-athlete academic performance, with a 10-year NCAA graduation rate of 91% compared to a national average of 85%.

Breslyn Apartments is a historic apartment complex located in the Spruce Hill neighborhood of Philadelphia, Pennsylvania. It was built in 1913, and consists of five three-story, brick and granite buildings with terra cotta and galvanized-iron trim in the Beaux Arts-style. Each building measures 38 feet wide and 98 feet deep. The buildings features large open porch-balconies with Ionic order columns, segmental-arch windows, bow and bay windows, and terra cotta piers with Corinthian order caps.It was added to the National Register of Historic Places in 1982.

Masjid Al-Jamia is a Sunni mosque in West Philadelphia. It was founded in 1988 by members of the Muslim Students Association at the University of Pennsylvania (Penn MSA). Eight years later, the mosque became independent from the Penn MSA and, around 2009, acquired ownership of the building. Located at 4228 Walnut Street, in a historic building formerly occupied by the Commodore Theatre, the mosque currently serves a large and diverse Muslim population in the neighborhood. The mosque's name itself signals its importance to the community, as the Arabic etymology suggests. In Arabic, Masjid Al-Jamia means “the congregational mosque”, typically where Muslims meet for Friday prayers.

The Restaurant School at Walnut Hill College (aka just Walnut Hill College) is a private, for-profit, family-run, culinary school in Philadelphia, Pennsylvania.

Henry C. Lea Elementary School is a historic elementary school located in the Walnut Hill neighborhood of Philadelphia, Pennsylvania. It is part of the School District of Philadelphia. The building was designed by Henry deCourcy Richards and built by Cramp & Co. in 1914. It is a three-story, five bay, reinforced concrete building faced with brick and with terra cotta and granite trim in the Late Gothic Revival-style. It sits on a raised basement. It features a Classical limestone center entrance surround, a central two-story bay window, decorative panels, crenelated parapet, and a projecting entrance bay. It was used as an "observation school" for teacher education and training.The building was added to the National Register of Historic Places in 1988 as the Henry C. Lea School of Practice.

Paul Robeson High School for Human Services is a district-run high school in Philadelphia with citywide admissions. The school is one of eight schools in the country that offers a focus in the human services field. The school is named after Paul Robeson.As part of Philadelphia's shutdown of 23 district-run schools in 2013, some displaced students from University City High School were relocated to Paul Robeson High School for Human Services.

Pinehurst Apartments, also known as Pine Street Place and Pine Terrace, is a historic apartment complex located in the Spruce Hill neighborhood of Philadelphia, Pennsylvania. It was built in 1914, and consists of two 3 1/2-story, reinforced concrete buildings faced in brick and granite. The buildings feature colonnaded porches with Corinthian order columns.It was added to the National Register of Historic Places in 1987.

The Institute of Pennsylvania Hospital, also known as Kirkbride's Hospital or the Pennsylvania Hospital for Mental and Nervous Diseases, was a psychiatric hospital located at 48th and Haverford Streets in Philadelphia, Pennsylvania, USA. It operated from its founding in 1841 until 1997. The remaining building, now called the Kirkbride Center is now part of the Blackwell Human Services Campus. Two large hospital structures and an elaborate pleasure ground were built on a campus that stretched along the north side of Market Street, from 45th to 49th Streets. Thomas Story Kirkbride, the hospital's first superintendent and physician-in-chief, developed a more humane method of treatment for the mentally ill there, that became widely influential. The hospital's plan became a prototype for a generation of institutions for the treatment of the mentally ill nationwide. The surviving 1859 building was designated a National Historic Landmark in 1965.

Walnut Hill is a neighborhood in the West Philadelphia section of Philadelphia, Pennsylvania. It is located between 45th Street and 52nd Street, bounded by Market Street and Spruce Street. Most of the neighborhood is in the northwestern part of the University City District. It is located north of the neighborhoods of Garden Court and Spruce Hill. It is a racially mixed neighborhood with a large seasonal student population. Walnut Hill was largely built from the start of the 20th century through the 1940s, with a large growth spurt immediately following the construction of what is now the SEPTA Market-Frankford Line. The primarily residential neighborhood consists of 2 and 3-story rowhomes, with several pre-war garden style apartments. West Philadelphia High School is located in Walnut Hill and The Restaurant School at Walnut Hill College is close by, if not technically within the boundaries of the neighborhood. In recent years, the Enterprise Center Community Development Corporation, in collaboration with the Walnut Hill Community Association, has made strides to spur development in the neighborhood. The La Blanche Apartments and Henry C. Lea School of Practice are listed on the National Register of Historic Places.American Bandstand was first broadcast from the ABC studio at 46th and Market Streets (now the Enterprise Center).Science fiction author Isaac Asimov lived at Wyngate Hall (now called The Terrace), a garden apartment building at 50th and Spruce, from 1942–1945, and wrote several of the stories that comprise I, Robot and the Foundation series while living there.Singer, actor and activist Paul Robeson lived with his sister at 50th and Walnut from 1968 until his death in 1976. A mural at 45th and Chestnut commemorates Robeson.From the 1930s through the 1970s the Philadelphia College of Osteopathic Medicine (PCOM) was located at 48th and Spruce, their former building now houses the Emmanual Church, a Korean language Presbyterian congregation.