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St. Francis Xavier Church is located at 611 Sycamore Street, Cincinnati, Ohio. This was the location of the first diocesan cathedral and the center of early Roman Catholic life in Cincinnati. It was dedicated to St. Peter on December 17, 1826. "Christ Church" (founded 1819), the city's first Catholic church was located at Vine and Liberty streets, in the "Northern Liberties" area, at the time outside of the city. A story that the church had to be built on the outskirts of the city because anti-Catholic prejudice prevented a Roman Catholic church within city limits has been shown to be false by church historians. Its frame building was moved on wheels to Sycamore Street in 1826 to serve as the first seminary. Saint Francis Seraph Church now is on the former site, on land purchased from James Findlay. St. Francis Xavier has existed as its own parish since 1845 when the cathedral was moved to Saint Peter In Chains Cathedral at Eight & Plum Streets. The parish has been under the direction of the Society of Jesus (Jesuits) since 1840. The present brick edifice with stone facing and ornate clock tower was built in 1860. Xavier University and St. Xavier High School were founded next to the St. Xavier Church. Both institutions have since moved to separate locations due to space constraints and expansion. Today the church serves the downtown community.

St. Xavier Parish Commercial School, officially The Convent School, was a private secondary school in Cincinnati, Ohio, United States. Founded in 1904 by the Sisters of Notre Dame de Namur, it remained open until 1960. It was associated with St. Francis Xavier Church of the Roman Catholic Archdiocese of Cincinnati. Fr. Francis J. Finn, S.J., served as its first director.The school was located on Sixth Street downtown, between Sycamore and Main Streets—most likely at 520 Sycamore St. It offered "a two-year course of study—primarily for women—in the business arts", including "stenography, book-keeping, and typesetting". Boys from St. Xavier High School also took typing classes there; once the Commercial School closed, the high school moved to Finneytown and the parish remained at the downtown location.Tuition was $50 a year during the 1950s.

The Power Building is a historic commercial building in the downtown of Cincinnati, Ohio, United States.

Gwynne Building is a registered historic building in Cincinnati, Ohio, listed in the National Register on August 3, 1979.

Arnold's Bar and Grill is the oldest continuously operating bar in Cincinnati, Ohio, and one of the oldest in the United States.

Wesley Chapel was a Methodist church in Cincinnati, Ohio, United States. Built in 1831 on the north side of Fifth Street between Broadway and Sycamore (39°06′08.2″N 84°30′26.4″W), it was a simple red brick Georgian structure copied after John Wesley's original Methodist church in London. With 1,200 seats, it was the largest meeting place west of the Alleghenies and the largest building in Cincinnati for many years. It was the seat of Methodism in Cincinnati. The funeral of William Henry Harrison took place there in 1841. In 1845, former president John Quincy Adams spoke at Wesley Chapel, dedicating the new Cincinnati Observatory being built on Mount Adams. In the years before the Civil War, political rallies and anti-slavery meetings frequently were held there. During the early years, a cemetery was near the Chapel on Fifth Street; when the Wesleyan Cemetery, was founded in 1843 many of the bodies were moved to the new cemetery. A long struggle took place between 1965 and 1972 between the Procter & Gamble Corporation and the people who wanted to save the oldest surviving church in the city, Wesley Chapel. P & G offered several options, including moving the building across the street. The congregation elected to build a new church in the Over-the-Rhine neighborhood. Wesley Chapel was demolished in 1972. The new Wesley Chapel is located at 80 East McMicken Avenue (39°06′54.5″N 84°30′52.9″W).

Cincinnati Times-Star Building at 800 Broadway Street in Cincinnati, Ohio, is a registered historic building. It was listed in the National Register on November 25, 1983. It was built in 1933 and was designed by the firm of Samuel Hannaford & Sons in the Art Deco style. The limestone building has 15 stories with a basement and sub-basement beneath. There is no 13th floor as superstitions ran high during this time period. Much of the decorated facade pays homage to the printing and publishing businesses. Two hundred feet above the street stand four pillars at each of the tower's corners; they represent patriotism, truth, speed, and progress. The newspaper plant occupied the first six stories. The floors above were offices. The Cincinnati Times-Star was an outgrowth of several newspapers and was owned by Cincinnati's Taft family. Charles Phelps Taft was editor. Before moving into the Times-Star Building on Broadway on January 1, 1933, the newspaper's offices were on Sixth and Walnut streets.When the Times-Star folded in 1958, its assets were purchased by its rival, The Cincinnati Post, who moved into the building and occupied it until 1984. Hamilton County bought the building in the late 1980s and renamed it the 800 Broadway Building. It is used for county offices and by the juvenile court.

Cincinnati East Manufacturing and Warehouse District is a registered historic district in Cincinnati, Ohio, listed in the National Register on March 12, 1999. It contains 23 contributing buildings. It is roughly bounded E. Court Street, E. 8th Street, Broadway, and Main Street in the central business district. The late 19th and early 20th century, buildings in the historic district are mostly five to seven stories tall and originally housed of industry and manufacturing operations.In the late 20th century, several contributing buildings to this historic district were converted from industrial space into luxury apartments and condominiums. The Power Building (1903) at 224 E. 8th Street was transformed into the Renaissance at the Power Building.

Antonelli College was a for-profit career training school with a main campus located in Cincinnati. Founded in 1947 as the Gebhardt Art School, the college later switched its name to Ohio Visual Art Institute in the mid-1970s then renaming itself to Antonelli College in 1982. In 2016, Antonelli College was ranked one of the top ten most expensive two-year colleges in Ohio

The Taft Theatre is a 2,500-seat theater, located in Cincinnati, Ohio. The theatre was built in 1928, as evidenced by its Art Deco interior. All seats are unobstructed, giving every seat a clear view of the stage. It is part of the Masonic Temple Building at Fifth and Sycamore streets. It is home to The Children Theatre of Cincinnati. As of 2010, it is operated by Music & Event Management Inc., a subsidiary of Cincinnati Symphony Orchestra. Music & Event Management Inc. also operates Riverbend Music Center and PNC Pavilion. The theatre underwent $3 million worth of upgrades and renovations for air conditioning, seating, restroom improvements and other amenities.It is used for Broadway shows, concerts, comedy and other special events. The theatre played host to the politically motivated Vote for Change Tour on October 2, 2004, featuring performances by Keb' Mo', Bonnie Raitt and Jackson Browne.

East Fourth Street Historic District is a registered historic district in Cincinnati, Ohio, listed in the National Register of Historic Places on February 22, 1988. It contains a row of 3 side-by-side contributing buildings dating circa 1860. The former headquarters Cincinnati Gas & Electric Company, completed in 1929, although not a contributing property, stands next door to the cluster of buildings at the southwest corner of Fourth and Main streets. Its tower can be seen in the left side of the image.

The PNC Center is a 108-meter (354 feet) tall office building located in Cincinnati, Ohio. It is located primarily in the Central Business District and borders Main Street and East Fifth Street. The building's 27 floors are used for office and commercial use. On the southeast corner of Fifth and Main streets is a public plaza. Built in 1979, this skyscraper was the tallest completed in Cincinnati during the 1970s decade. It initially served as headquarters of Central Trust Bank, which PNC acquired in 1988. With the acquisition, PNC also became the lead tenant of the historic PNC Tower, Central Trust's headquarters before the 1979 building was constructed. The building's exterior is typical of 1970s architecture. It features a lightly colored exterior wall with tinted rectangular windows. Unusual for architecture of the time, there are a number of setbacks in the building, both horizontally and vertically. The building has no crown or topped area which is also typical of 1970s architecture. The roof is flat. The building was designed by Skidmore, Owings & Merril.