East Fourth Street Historic District (Cincinnati, Ohio)

The Potter Stewart United States Courthouse is a courthouse and federal building of the United States government located in Cincinnati, Ohio, and housing the headquarters of the United States District Court for the Southern District of Ohio and the United States Court of Appeals for the Sixth Circuit. Completed in 1938, it was renamed for Supreme Court Justice Potter Stewart in 1994. It was listed on the National Register of Historic Places in 2015.

The United States District Court for the Southern District of Ohio (in case citations, S.D. Ohio) is one of two United States district courts in Ohio and includes forty-eight of the state's eighty-eight counties–everything from the Columbus area southward. Appeals from the court are taken to the United States Court of Appeals for the Sixth Circuit at Cincinnati (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit). The United States Attorney's Office of the Southern District of Ohio represents the United States in civil and criminal litigation in the court. On February 12, 2014, Peter C. Tobin was confirmed to be the United States Marshal. As of November 2021, the United States Attorney is Kenneth L. Parker.

The Federal Reserve Bank of Cleveland Cincinnati Branch Office is one of two Federal Reserve Bank of Cleveland branch offices (the other is in Pittsburgh). The Cincinnati Office of the Federal Reserve Bank of Cleveland provides currency distribution services for financial institutions in multiple Reserve Districts.James M. Anderson is the current chairman.

Gwynne Building is a registered historic building in Cincinnati, Ohio, listed in the National Register on August 3, 1979.

The PNC Center is a 108-meter (354 feet) tall office building located in Cincinnati, Ohio. It is located primarily in the Central Business District and borders Main Street and East Fifth Street. The building's 27 floors are used for office and commercial use. On the southeast corner of Fifth and Main streets is a public plaza. Built in 1979, this skyscraper was the tallest completed in Cincinnati during the 1970s decade. It initially served as headquarters of Central Trust Bank, which PNC acquired in 1988. With the acquisition, PNC also became the lead tenant of the historic PNC Tower, Central Trust's headquarters before the 1979 building was constructed. The building's exterior is typical of 1970s architecture. It features a lightly colored exterior wall with tinted rectangular windows. Unusual for architecture of the time, there are a number of setbacks in the building, both horizontally and vertically. The building has no crown or topped area which is also typical of 1970s architecture. The roof is flat. The building was designed by Skidmore, Owings & Merril.

The Formica Building is a mixed-use building in Cincinnati, Ohio.

The Mercantile Library of Cincinnati is a membership library located in downtown Cincinnati, Ohio. The name of the Library refers not to the type of items in its collection but to the forty-five merchants and clerks who founded it on April 18, 1835 as the Young Men's Mercantile Library Association.

The Maisonette, now defunct, was North America’s most highly rated restaurant before it closed its doors on July 25, 2005.Owned and operated by the Comisar family and located since 1966 at 114 E. 6th Street in Cincinnati, Ohio, the Maisonette boasted the longest running streak of five-star awards, the highest designation given by Mobil Travel Guide. That streak ended at 41 years when the Maisonette closed. Opinions vary on what caused the restaurant to lose its luster. Fewer people frequented the luxury restaurant, operating costs increased, and the City of Cincinnati refused to offer a tax break to the downtown landmark. The Maisonette had plans to move to Kenwood, a suburb of Cincinnati, where it would reinvent its image, hoping to attract a more modern, younger crowd; however, the Hamilton County Planning Commission rejected zoning for the proposed Sycamore Square project, a $60 million development that included a relocated Maisonette as the anchor tenant. Instead, the top-rated French cuisine restaurant auctioned off all of its assets through a two-day auction hosted by the Great American Group auction firm. The most expensive item sold at auction was the Maisonette's name/logo, which sold for $35,000. The restaurant originally opened in 1949. In 1964 the restaurant won its first 5-star rating from Mobil. In 2013, the Phoenix Restaurant Group located in Cincinnati, OH acquired the trademark for The Maisonette in order to preserve and safeguard its history and reputation.

On September 6, 2018, a mass shooting occurred in Cincinnati, Ohio, United States. At 9:10 AM EDT, Omar Santa Perez, 29, opened fire with a Taurus PT-809E 9mm pistol equipped with standard and hollow-point ammunition, in the lobby of the Fifth Third Center in Cincinnati, Ohio, killing three people. He was then shot and killed by responding police officers.

Fifth Third Center is a skyscraper located in downtown Cincinnati, in the U.S. state of Ohio on Fountain Square. The building has 30 stories and rises to a height of 423.23 feet (129.00 m). It is currently the fifth-tallest building in Cincinnati. It was designed by Harrison & Abramovitz and completed in 1969. The building serves as the corporate headquarters for Fifth Third Bank. On September 6, 2018, the building was the site of a mass shooting, in which four people were killed, including the suspect. Two others were also injured in the shooting.

St. Francis Xavier Church is located at 611 Sycamore Street, Cincinnati, Ohio. This was the location of the first diocesan cathedral and the center of early Roman Catholic life in Cincinnati. It was dedicated to St. Peter on December 17, 1826. "Christ Church" (founded 1819), the city's first Catholic church was located at Vine and Liberty streets, in the "Northern Liberties" area, at the time outside of the city. A story that the church had to be built on the outskirts of the city because anti-Catholic prejudice prevented a Roman Catholic church within city limits has been shown to be false by church historians. Its frame building was moved on wheels to Sycamore Street in 1826 to serve as the first seminary. Saint Francis Seraph Church now is on the former site, on land purchased from James Findlay. St. Francis Xavier has existed as its own parish since 1845 when the cathedral was moved to Saint Peter In Chains Cathedral at Eight & Plum Streets. The parish has been under the direction of the Society of Jesus (Jesuits) since 1840. The present brick edifice with stone facing and ornate clock tower was built in 1860. Xavier University and St. Xavier High School were founded next to the St. Xavier Church. Both institutions have since moved to separate locations due to space constraints and expansion. Today the church serves the downtown community.

St. Xavier Parish Commercial School, officially The Convent School, was a private secondary school in Cincinnati, Ohio, United States. Founded in 1904 by the Sisters of Notre Dame de Namur, it remained open until 1960. It was associated with St. Francis Xavier Church of the Roman Catholic Archdiocese of Cincinnati. Fr. Francis J. Finn, S.J., served as its first director.The school was located on Sixth Street downtown, between Sycamore and Main Streets—most likely at 520 Sycamore St. It offered "a two-year course of study—primarily for women—in the business arts", including "stenography, book-keeping, and typesetting". Boys from St. Xavier High School also took typing classes there; once the Commercial School closed, the high school moved to Finneytown and the parish remained at the downtown location.Tuition was $50 a year during the 1950s.