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The Hyatt Regency New Orleans is a 32-story, 361-foot (110 m)-tall hotel located at 601 Loyola Ave in the Central Business District of New Orleans, Louisiana. It has 1,193 guest rooms, including 95 suites. It is part of a complex of connected buildings, which includes the Mercedes-Benz Superdome, 1250 Poydras Plaza, Entergy Tower, and the Benson Tower. Originally opened in 1976, it was designed by Welton Becket and Associates. The Hyatt was severely damaged by Hurricane Katrina in 2005 and remained closed for six years, until 2011.

Champions Square is an outdoor festival plaza located adjacent to Caesars Superdome in New Orleans, Louisiana. It is known as the premier tailgating space for sports events held at the stadium and the nearby Smoothie King Center. The plaza also consists of an outdoor amphitheater, known as Bold Sphere Music (often referred to as "Blue Sphere Stage"). The venue was reopened April 25, 2014, with a concert by Lana Del Rey.The amphitheater has seating for up to 9,000 spectators for special events, 7,000 in a general admission setting and 4,500 for reseated seating.

1250 Poydras Plaza (also known as the Eni Building and formerly the Mobil Building), is a high-rise international-style office building located at 1250 Poydras Street in the Central Business District of New Orleans, Louisiana. It has 24 stories, and stands at a height of 342 feet (104 m). In June 2010, the Unified Command moved its headquarters from the Dutch Royal Shell Conference Center in Robert, Louisiana, to the building to deal with the Deepwater Horizon oil spill.

Entergy Tower (also known as One Poydras Plaza), located at 639 Loyola Avenue in the Central Business District of New Orleans, Louisiana, is a 28-story, 360 feet (110 m)-tall skyscraper. The building used to have the Consulate-General of Japan in New Orleans. In 2006, the Japanese Government announced that it was moving the consulate to Nashville, Tennessee. The diplomatic mission was relocated to be closer to industries and operations owned by Japanese companies.

Orleans Tower (formerly Amoco Building), located at 1340 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 20-story, 280 feet (85 m)-tall skyscraper designed in the international style by 3D/International. The international style grew in popularity during the sixties and seventies after the architect Mies Van Der Rohe designed the Seagram Building on Park Ave in New York City and Skidmore, Owings, and Merrill designed the Sears Tower in the heart of downtown Chicago. The building is primarily used for leaseable office space, with some retail space on the ground level. The design of the building can be best classified as international with its black aluminum and glass curtain wall. The building currently houses the offices of several city and state agencies, including the Orleans Parish District Attorney's Office. Orleans Tower is currently the 28th tallest building in New Orleans.

The Girod Street Cemetery (also known as the Protestant Cemetery), was a large above-ground cemetery that resided in central New Orleans, Louisiana, established in 1822 for Protestant residents of the Faubourg St. Mary and was closed down in the 1940s. The cemetery then remained unused, until it was officially torn down on January 4, 1957.

The Energy Centre, located in the Central Business District of New Orleans, Louisiana, is a 39-story, 530 feet (162 m) -tall skyscraper designed by HKS, Inc. It is the fourth tallest building in both the city of New Orleans and the state of Louisiana. A four-story parking garage is adjacent to the tower, one block upriver. The garage is accessible from both Loyola Avenue and South Rampart Street. The building experienced minor damage during Hurricane Katrina in August 2005. Some windows near the top of the tower were blown out, however, these windows were mostly false windows that cover the climate control systems on the roof. The ceilings of the overhangs on the street level were badly damaged but have since been repaired.

Benson Tower (formerly Dominion Tower and the CNG Tower), located at 1450 Poydras Street in the Central Business District of New Orleans, Louisiana, is a 26-story, 406 feet (124 m)-tall skyscraper. The building was purchased by late New Orleans Saints owner Tom Benson on September 15, 2009 and renamed the Benson Tower. In 2012, Ochsner Health System moved executives and as many as 750 administrative employees to the top four floors as well as the 2nd and 3rd floor space with balconies overlooking Champions Square and the Caesars Superdome; second floor space is utilized for Benson's television station, Fox affiliate WVUE (Channel 8) for the station's morning newscast, sporting events and by lease for other parties. According to Corporate Realty, which leases the 487,760 sq ft (45,314 m2) building, as of August 2012, Benson Tower is more than 97.6% leased.

The Karnofsky Tailor Shop–House (also known as the Karnofsky Shop) was a historic, two-story building in the Central Business District of New Orleans, Louisiana, that played a significant role in the early promotion of jazz when the neighborhood was known as "Back of Town". It was destroyed by Hurricane Ida in 2021.

The John Minor Wisdom U.S. Court of Appeals Building, located at 600 Camp Street in New Orleans, Louisiana, is a historic courthouse for the United States Court of Appeals for the Fifth Circuit. In 2015 it was designated a National Historic Landmark for its extensive role in adjudicating issues of the American Civil Rights Movement of the 1950s and 1960s. John Minor Wisdom, for whom it is now named, was a judge on the Fifth Circuit during that period.

The Civic Theatre is a 1,200-seat theater located in New Orleans, Louisiana. The theatre was originally built in 1906 and is used for concerts, plays, films, corporate events and private parties.

930 Poydras is a 21-story, 270.31-foot (82.4 m) residential skyscraper in New Orleans, Louisiana. Located on Poydras Street, the main thoroughfare in the city's Central Business District (CBD), it is the tallest building completed in the city in the 2010s and the first residential skyscraper completed in the city following Hurricane Katrina. Some sources affirm that the building was financed via Gulf Opportunity Zone financing that was enacted by the United States Congress to aid in the recovery from Katrina, while other sources state that alternative financing was used. The building's construction was the subject of a court battle regarding damage to surrounding buildings. Nonetheless, the building's design, which was scaled back from early plans, has won many awards.