Teatro La Perla

Casa Salazar-Candal (English: Salazar–Candal House) is a historic building located on the southeast corner of Isabel and Mayor Cantera streets in Ponce, Puerto Rico, in the city's historic district. The building dates from 1911. It was designed by the architect Blas Silva. The architecture consists of 19th Classical revival, Art Nouveau and Spanish Revival architectural styles. Today the Salazar–Candal Residence houses the Museum of the History of Ponce.

The Museo de la Historia de Ponce (Museum of the History of Ponce) is a local history museum located in the historic Casa Salazar-Candal in the city of Ponce, Puerto Rico. The museum depicts the city's ecology, economy, architecture, government, and elements of daily life. It seeks to promote the research, conservation, and dissemination of the historic heritage of Ponce and Puerto Rico.Inaugurated on 12 December 1992, it was the first museum in Puerto Rico established to cover the history of the people of a town or city. It traces the city's history from the Taino Indians to today. The museum was inaugurated under the administration of Mayor Rafael Cordero Santiago, as part of the tricentennial celebration of the founding of the city.It is located in the historic district of the city, a short two-block walk from the central Plaza Las Delicias town square, at the southeast corner of Isabel and Mayor Cantera streets. The museum proper is housed in the historic Casa Salazar-Candal but also includes the neighboring Rosali-Zapater house, which houses administratives offices of the museum, in addition to the empty lot that once held the residence of the Schuck Gelpí family. In 2012, plans were announced to expand the museum into the Casa Rosita Serrallés, an adjacent property. In 2014, Casa Rosita Serralles (Calle Salud street #67) joined Museo de la Historia de Ponce and opened as "Museo de la Recordacion Barrio Mameyes" (Barrio Mameyes Memorial Museum) under Ponce mayor María Meléndez. It is also known as "Sala Memorial del Barrio Mameyes" as it operates as a part of the Museo de la Historia de Ponce.

Residencia Ermelindo Salazar (Ermelindo Salazar Home) is a historic house in Ponce, Puerto Rico. It was built in 1870 as the home of Ermelindo Salazar, a prominent citizen and businessman in the city as well as its mayor in 1880. It is located at 70 Cristina street in the Ponce Historic Zone, in Barrio Tercero, Ponce, Puerto Rico. Today the house serves as the headquarters of the Centro Cultural de Ponce Carmen Solá de Pereira, the cultural center of the city of Ponce, where it is used for educational and cultural activities as well as for art exhibits.

Centro Cultural Carmen Solá de Pereira de Ponce (English: Carmen Solá de Pereira Ponce Cultural Center) is the cultural center of the city of Ponce, and is located at 70 Cristina street in the Ponce Historic Zone, in Barrio Tercero, Ponce, Puerto Rico. The Center is located in a structure designed in 1870, and it is currently used for educational and cultural activities as well as for art exhibits. Centro Cultural de Ponce was founded on 12 November 1963.

The Museo de la Música Puertorriqueña (English: Museum of Puerto Rican Music) is a museum in Ponce, Puerto Rico, that showcases the development of Puerto Rican music, with displays of Taíno, Spanish, and African musical instruments that were played in the romantic danza genre, the favorite music of 19th-century Puerto Rican high society, as well as the more African-inspired bomba and plena styles. Also on display are memorabilia of composers and performers. The Museum traces the rich musical history of Puerto Rico through memorabilia of prominent musicians and displays of the musical instruments associated with the three genres of music that originated in this Caribbean island.The building that houses the museum is known as Casa Serrallés and it was the former downtown residence (as opposed to his hilltop Castillo Serrallés structure) of Juan Eugenio Serrallés and his family, owners of Destilería Serrallés and makers of the Don Q rum.

Hotel Meliá is a historic colonial style family owned and operated hotel located in the Ponce Historic Zone in Ponce, Puerto Rico. It is the oldest continuously operating hotel in Puerto Rico. Hotel Meliá, which was founded over 60 years before the much larger Meliá Hotels International chain opened its first lodging facility, bears no relation to the multi-hotel chain headquartered in Spain.

The Ponce High School is public educational institution in Ponce, Puerto Rico, offering grades nine through twelve. The school's main building is a historic structure located on Cristina Street, in the Ponce Historic Zone. From its beginning the school has secured a unique place in Puerto Rico's educational history. Of over 3,000 schools erected in Puerto Rico in the first quarter of the twentieth century, Ponce High was the largest, "at a time enrolling more students than all the other Puerto Rico high schools combined", and for many years enrolling more students than any other high school in Puerto Rico. The cost of the building in 1915 dollars was $150,000 USD ($4.34 million in 2022 dollars). The building was listed on the U.S. National Register of Historic Places on 4 August 1987. The school has the only diamond-level DECA chapter in Puerto Rico. The Ponce High School building is "among the most important public buildings ever built in Puerto Rico." The school is the oldest continuously-operating high school in Puerto Rico.

The Banco Crédito y Ahorro Ponceño building (or Banco Crédito, for short), a historic building in Ponce, Puerto Rico, was the first and main office of the historic Banco Crédito y Ahorro Ponceño (English: Ponce Credit and Savings Bank), and represents one of the last examples of the once popular turn-of-the-century eclectic architecture. The building was listed on the U.S. National Register of Historic Places on June 25, 1987. It was built in 1924. The building was owned by Banco Crédito y Ahorro Ponceño which was one of the largest banking companies in the country of Puerto Rico during most of the twentieth century.

Los Chinos de Ponce (English: "The Chinesemen of Ponce"), formally King's Cream, is an Ice cream parlor located at Calle Marina 9322 in the city of Ponce, Puerto Rico, in front of the town square, Plaza Degetau, opposite the historic Parque de Bombas. Critics have called the site "a Puerto Rican institution" and its ice cream "the Caribbean's best." It has also been called "Puerto Rico's most famous ice cream stand." Another critic called it "[the reason] for which I'll always remember Ponce."

The Banco de Ponce building, a historic building in Ponce, Puerto Rico, was the first and main office of Banco de Ponce until the company merged with Banco Popular in 1990. Though its headquarters had moved to a presumptuous building in Hato Rey's Milla de Oro by then, Banco de Ponce continued to consider this building its main office, until the company merged with Banco Popular in 1990. The building was listed on the U.S. National Register of Historic Places on June 25, 1987. It was built in 1924.

Banco Crédito y Ahorro Ponceño (Ponce Credit and Savings Bank) was the first bank in Ponce, Puerto Rico, and one of the first two native Puerto Rican banks to be established in Puerto Rico. The bank was the first one to introduce a bank credit card to the Puerto Rican market. With over 50 branches throughout the island, the bank was one of the largest banking companies in Puerto Rico during most of the twentieth century. Founded in 1895, Banco Crédito built its own first banking structure in 1924 at Calle Marina and Callejón Amor, in Ponce. This first branch office, located in what is today the Ponce Historic Zone, has since been declared historic and was listed in the National Register of Historic Places.The bank collapsed in 1978 and was acquired by the Federal Deposit Insurance Corporation. Its accounts and assets were purchased by Banco Popular de Puerto Rico and Banco Santander.

Banco de Ponce was the Puerto Rican bank with the largest number of branches in the United States and second largest bank in deposits and number of branches in Puerto Rico during the twentieth century. Founded in Ponce, Puerto Rico, in the early part of the century, it headquartered in San Juan in 1970 and, 20 years later, merged with Banco Popular forming BancPonce Corporation.