326, 328, and 330 East 18th Street

Mount Sinai Beth Israel is a 799-bed teaching hospital in Manhattan. It is part of the Mount Sinai Health System, a nonprofit health system formed in September 2013 by the merger of Continuum Health Partners and Mount Sinai Medical Center, and an academic affiliate of the Icahn School of Medicine at Mount Sinai.

Lying-In Hospital, which was chartered in 1799, was given a strong boost in 1897 with "the magnificent gift of $1,000,000" from J. Pierpont Morgan. It relocated more than once, both before and after Morgan's donation. Their focus was expectant women. Lying-In Hospital merged in 1932 with New York Hospital, and the original name was dropped. Their "Second Avenue, between 17th and 18th Streets" location "was redeveloped as an apartment building in the 1980s."

The Society for the Lying-In Hospital was an American maternity hospital situated at 305 Second Avenue between East 17th and 18th Streets in the Stuyvesant Square neighborhood of Manhattan, New York City. Now known as Rutherford Place, the building was added to the National Register of Historic Places in 1983. Lying-in is an archaic term for childbirth (referring to the month-long bed rest prescribed for postpartum confinement). It was built in 1902 and designed by architect R. H. Robertson in the Renaissance Revival style, with a Palladian crown at the top. Swaddled babies decorate the windows of the 5th floor and the spandrels of the building, which was converted to offices and apartments in 1985 by Beyer Blinder Belle.As the years passed, John Pierpont Morgan, Jr. was concerned about the long-term stability of the hospital his father had so generously provided for. He recruited John D. Rockefeller, Jr.; George F. Baker, Sr.; and George F. Baker, Jr. to join forces in establishing an association with New York Hospital. Upon the subsequent opening of the New York Hospital-Cornell Medical Center in 1932, the Lying-In Hospital moved out of the Second Avenue building. It became the more modern-sounding Obstetrics and Gynecology Department of New York Hospital, which is still part of NewYork–Presbyterian Hospital. This hospital was "said to account for 60 percent of all births in Manhattan." Some of their staff did medical research.

The Institute for Collaborative Education (also called ICE) is a college-preparatory public secondary school (grades 6–12) in the Gramercy Park neighborhood of Manhattan in New York City near Stuyvesant Town–Peter Cooper Village. Part of the DOE's District 2, the school is known for its small class sizes and progressive educational values. The school is philosophically opposed to high-stakes standardized tests. It is a member of the New York Performance Standards Consortium and is "given a waiver from the chancellor's uniform curriculum." As a Consortium school, ICE's students are exempt from taking most Regents exams. Instead, students present "PBAT" (Performance-Based Assessment Task) projects at the end of each semester to panels of teachers, parents, and outside community members. Until recently, ICE was a screened school, requiring middle school applicants to submit an essay and undergo an interview. After the COVID-19 pandemic, the school changed to a lottery system, but with two "priority groups": Diversity: 50% of the school's seats go to students who qualify for free or reduced-price lunch Sibling priority: Students with a sibling currently in 6th through 11th grade at ICE have priority

Stuyvesant Square is the name of both a park and its surrounding neighborhood in the New York City borough of Manhattan. The park is located between 15th Street, 17th Street, Rutherford Place, and Nathan D. Perlman Place (formerly Livingston Place). Second Avenue divides the park into two halves, east and west, and each half is surrounded by the original cast-iron fence.The neighborhood is roughly bounded by 14th Street to the south, 18th or 19th Street to the north, First Avenue to the east, and Third Avenue to the west. It is part of Manhattan Community Board 6.

The High School for Health Professions and Human Services is a public high school in Manhattan, New York City. It is specialized for students preparing for careers in the healthcare and human resources fields.The curriculum emphasizes the academic preparation necessary for these fields. Students take four years of both mathematics and science, and there are elective research programs and college level courses in both the sciences and the humanities. The High School for Health Professions and Human Services offers a range of science courses as part of a traditional high school curriculum. Top students may conduct research with mentors at nearby hospitals and a few may even compete in the Intel Science Talent Search. The school also offers courses in nutrition, forensics, and a combined art and anatomy class.

The Salk School of Science is a renowned junior high school in Gramercy, Manhattan, New York City and is a very competitive school. For the class of 2023, the admissions rate was just above 4%. It was founded in 1995 as a unique collaboration between the New York University School of Medicine and the New York City Department of Education. The goal of the school is to encourage an enthusiasm for, and the development of abilities in, the sciences, particularly the medical and biological sciences. Science and math are specialties at the school, including special classes for it and after-school programs. A particular aim is to encourage city children to aim for better high schools and colleges. It is located on the top two floors of the P.S. 40 building on East 20th Street between 1st and 2nd Avenues in Manhattan.The school was named for Jonas Salk, developer of the first polio vaccine. Dr. Salk approved the use of his name by NYU before his death in 1995. The school's nontraditional discovery-based learning methodology has been cited as resulting in improved cognitive and reasoning skills in students.Members of the New York medical community work with the school to develop curriculum, and members of the Schools of Medicine and New York University School of Dentistry at New York University teach and mentor students in grades 6 through 8. The NYU Medical Center makes facilities available to the school, and members of the science faculty of the NYU School of Medicine review school students at certain points in their school career, notably at admission and graduation.Although the school is dubbed as a "Science School", the middle school spends an equal amount of time on Humanities (Reading, Writing and Social Studies), as well as Math. Other notable classes include Spanish, Art, Physical Education, Technology, Health and Drama. The principal of the school is Rhonda Perry and the vice/assistant principal is Jennifer Goodwin. The school allows students to bring money to school and at lunch time, to go out and buy themselves lunch at a variety of delis and restaurants. The school shares its building with another school, P.S. 40 which owns most of the building. There is a gymnasium, a cafeteria which is shared between the schools, and 2 floors exclusive to Salk School of Science. Both are located near the top of the building. There are 3 entrances one to the left side of the building, one to the right and one in the center. Students will normally exit through the right hand exit. There is school bus service which will bring students to and from school, thought most students take public transportation.

The 19th Street station was a local station on the demolished IRT Second Avenue Line in Manhattan, New York City. It had two levels. The lower level had two tracks and two side platforms and served local trains. The upper level had one track for express trains. The next stop to the north was 23rd Street. The next stop to the south was 14th Street. The station closed on June 13, 1942.

The St. George or The St. George Residence, now functioning under the name of Hotel 17 is a historic building located at 223–225 East 17th Street, on Stuyvesant Square in Manhattan, New York City. It was designated as part of the Stuyvesant Square Historic District, a New York City landmark district, in 1975.

New York Eye and Ear Infirmary of Mount Sinai (NYEE) is located at East 14th Street and Second Avenue in lower Manhattan, New York City. Founded on August 14, 1820, NYEE is America's first specialty hospital and one of the most prominent in the fields of ophthalmology and otolaryngology in the world, providing primary inpatient and outpatient care in those specialties. Previously affiliated with New York Medical College, as of 2013 it is affiliated with the Icahn School of Medicine at Mount Sinai as a part of the membership in the Mount Sinai Health System.

St. George's Episcopal Church is a historic church located at 209 East 16th Street at Rutherford Place, on Stuyvesant Square in Manhattan, New York City. Called "one of the first and most significant examples of Early Romanesque Revival church architecture in America", the church exterior was designed by Charles Otto Blesch and the interior by Leopold Eidlitz. It is one of the two sanctuaries of the Calvary-St. George's Parish.

Cabrini Medical Center of New York City was created in 1973 by a merger of two Manhattan hospitals. It closed in 2008 due to financial difficulties cited by the Berger Commission, followed by a bankruptcy filing.In January 2010, the five buildings formerly housing the medical center were purchased by Memorial Sloan-Kettering Cancer Center for $83.1 million, with plans to open an outpatient cancer facility; but in 2013 the buildings were sold to a developer to be converted into residences.