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The Avondale Mine disaster was a massive fire at the Avondale Colliery near Plymouth Township, Pennsylvania, on September 6, 1869. It caused the death of 110 workers. It started when the wooden lining of the mine shaft caught fire and ignited the coal breaker built directly overhead. The shaft was the only entrance and exit to the mine, and the fire trapped and suffocated 108 of the workers (the other two fatalities were rescuers). It was the greatest mine disaster to that point in American history. One of the first global relief efforts occurred after the disaster, with donations for the families of victims arriving from all over the world. Another result of the fire was the enacting by the Pennsylvania General Assembly of legislation establishing safety regulations for the coal mining industry, making Pennsylvania the first state to enact such legislation. These laws mandated, among other things, that there must be at least two entrances to underground mines. The disaster also caused thousands of miners to join the Workingmen's Benevolent Association, one of the first unions to represent coal miners in the United States. Continuing labor and social strife in the Pennsylvania anthracite coal fields resulted in an increase of the activities of the "Molly Maguires", a controversial organization that conducted violent attacks against anthracite coal mine operators. These conflicts eventually resulted in the trial and execution of twenty members of the Molly Maguires in Pottsville and Jim Thorpe.

Nanticoke Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States. It is approximately 4.4 miles (7.1 km) long and flows through Hanover Township and Nanticoke. The watershed of the creek has an area of 7.57 square miles (19.6 km2). The creek has one named tributary, which is known as Espy Run. Nanticoke Creek impaired by pH and metals due to abandoned mine drainage. Abandoned mine drainage discharges in the creek's watershed include the Truesdale Mine Discharge and the Askam Borehole. The creek is located in the Northern Middle Anthracite Field and is in the Anthracite Valley Section of the ridge and valley physiographic province. The main rock formations in the watershed include the Mauch Chunk Formation, the Pottsville Group, and the Llewellyn Formation. The surficial geology consists of coal dumps, surface mining land, alluvium, Wisconsinan Outwash, Wisconsinan Till, urban land, and bedrock. The watershed of Nanticoke Creek is mainly forested, but urban land and mining land are also present. The city of Nanticoke is partially in the watershed and many unincorporated communities are there as well. The creek is named after the Nanticoke tribe, but was historically known as Muddy Run before appearing on maps with its present name by 1776. Extensive mining, both underground and on the surface, has been done in the creek's watershed. Numerous passive and active treatment systems have been installed in the watershed in recent times. Nanticoke Creek is designated as a Coldwater Fishery and a Migratory Fishery. However, it is relatively lacking in aquatic life.

Espy Run is a tributary of Nanticoke Creek in Luzerne County, Pennsylvania, in the United States. It is approximately 2.4 miles (3.9 km) long and flows through Nanticoke and Hanover Township. The watershed of the stream has an area of 3.14 square miles (8.1 km2). The stream is affected by abandoned mine drainage and has been affected by sewage in the past. The Espy Run Wetlands and the Espy Run discharge are in the stream's vicinity. The surficial geology in the area consists of urban land, coal dumps, surface mining land, Wisconsinan Till, Wisconsinan Ice-Contact Stratified Drift, and bedrock.

Warrior Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States. It is approximately 3.0 miles (4.8 km) long and flows through Warrior Run, Sugar Notch, and Hanover Township. The watershed of the creek has an area of 4.51 square miles (11.7 km2). It is designated as a Coldwater Fishery. However, it is considered to be impaired by abandoned mine drainage. The surficial geology in the creek's vicinity consists of alluvium, fill, urban land, strip mining land, Wisconsinan Till, and bedrock.

Newport Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States. It is 4.9 miles (7.9 km) in length. Named tributaries of the creek include South Branch Newport Creek. The entire watershed of Newport Creek is considered by the Pennsylvania Department of Environmental Protection to be impaired.

Nanticoke is a city in Luzerne County, Pennsylvania, United States. As of the 2020 census, the population was 10,628, making it the third largest city in Luzerne County. It occupies 3.6 square miles (9.3 km2) of land. Nanticoke is part of Northeastern Pennsylvania. The city can be divided into several sections: Honey Pot (northwestern Nanticoke), (northern and central Nanticoke), and Hanover Section (southeastern Nanticoke). It was once an active coal mining community. Today, the 167-acre main campus of Luzerne County Community College is located within the city.

West Nanticoke is a census-designated place (CDP) in Plymouth Township, Luzerne County, Pennsylvania, United States, across the Susquehanna River from the city of Nanticoke. The population of the CDP was 749 at the 2010 census.

WSFX (89.1 FM, "The Cutting Edge") is a radio station broadcasting an alternative music format. Licensed to Nanticoke, Pennsylvania, United States, the station is owned by Luzerne County Community College.

Harveys Creek (also known as Harvey Creek or Harvey's Creek) is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States. It is approximately 14.5 miles (23.3 km) long and flows through Harveys Lake, Lake Township, Lehman Township, Jackson Township, and Plymouth Township. The creek's watershed has an area of 46.3 square miles (120 km2). The creek has four named tributaries, which are known as Bear Hollow Creek, Paint Spring Run, Pikes Creek, and East Fork Harveys Creek. The watershed is designated as a High-Quality Coldwater Fishery and a Migratory Fishery above Pikes Creek and as a Coldwater Fishery and a Migratory Fishery below it. The creek's source is Harveys Lake, the largest natural lake in Pennsylvania. Harveys Creek was used as a water supply as early as the beginning of the 1900s. A number of bridges have been constructed over the creek since the 1920s, and it has been dammed by the Bryant Pond Dam. It is possible to canoe on part of the creek. Rock formations consisting of sandstone and shale occur in the watershed.

Luzerne County Community College (LCCC) is a public community college in Nanticoke, Pennsylvania. LCCC offers over 100 academic, technical, and career programs. The institution uses an open admissions policy for most programs, and has over 35,000 graduates. In addition to the 167-acre main campus in Nanticoke, the school maintains 7 satellite learning centers located throughout Northeastern Pennsylvania. LCCC Dedicated Centers are located in Berwick, Wilkes-Barre, Scranton, Shamokin, Hazleton, Pittston, and Watsontown. The college is accredited by the Middle States Commission on Higher Education. It offers 71 occupational programs (includes degree, certificate, and diploma programs), 25 liberal arts/transfer programs, 10 credit-free career training programs as well as numerous conferences, seminars, workshops, and business/industry customized training either on-campus or throughout the community During the fall 2019 semester approximately 9,000 students were enrolled in credit and noncredit courses. The student to faculty ratio is 18:1.

South Branch Newport Creek is a tributary of Newport Creek in Luzerne County, Pennsylvania, in the United States. It is 3.6 miles (5.8 km) long. The entire watershed of the creek is considered by the Pennsylvania Department of Environmental Protection to be impaired. Mining has also been done in the watershed.

The Askam Borehole is a borehole that is located in Luzerne County, Pennsylvania, in the United States. It is situated in the watershed of Nanticoke Creek north of PA 29 and Dundee Road and contributes several million gallons of acid mine drainage to that creek daily. The borehole also discharges large loads of iron and other substances. It was constructed by the Pennsylvania Department of Environmental Protection in the early 1970s and drains mine water from the South-East Mine Pool Complex. The discharges of the borehole have been treated by active treatment systems and artificial wetlands. It is located at approximately 41.200509, -75.966600 GPS coordinates.