Ford Motor Company Assembly Plant (Pittsburgh, Pennsylvania)

The UPMC Hillman Cancer Center (Hillman), previously titled the University of Pittsburgh Cancer Institute (UPCI), is a National Cancer Institute (NCI)-designated Comprehensive Cancer Center located in the Hillman Cancer Center in the Shadyside neighborhood of Pittsburgh, Pennsylvania, United States, adjacent to UPMC Shadyside. The only NCI-designated cancer center in Western Pennsylvania, Hillman is composed of collaborative academic and research efforts between the University of Pittsburgh, the University of Pittsburgh Medical Center (UPMC), and Carnegie Mellon University. Hillman provides clinical cancer care to some 74,000 patients treated at its facilities at both the Hillman Cancer Center location in the Shadyside neighborhood of Pittsburgh and at UPMC-affiliated sites throughout Pennsylvania, New York, Ohio, and overseas locations. Founded in 1984, Hillman became the youngest cancer center in history to achieve NCI-designation. As of 2007, Hillman had received nearly $200 million in funding from the National Cancer Institute, which ranks it as one of the top ten cancer research institutes.

The Bindley Hardware Company Building in the Shadyside neighborhood of Pittsburgh, Pennsylvania was built in 1903 alongside of the Pennsylvania Railroad main line, next to the Shadyside Station. The building was constructed for John Bindley by his brother Albion. John had been the president of the Pittsburgh Chamber of Commerce and of the National Hardware Association. He tried to organize the industry into a "National Combine" or trust, but this attempt failed due to opposition from the government. Instead, he organized a dominant regional hardware wholesaler in Pittsburgh, a major center of hardware manufacture, with this building serving as its main warehouse.The building was listed on the National Register of Historic Places in 1985.

Winchester Thurston School is an independent, coeducational preparatory school located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. Established in 1887, Winchester Thurston offers PK–12 education in Lower, Middle, and Upper School. The school is a member of the Pittsburgh Consortium of Independent Schools.

UPMC Shadyside is a nationally ranked, 520-bed non-profit, tertiary, teaching hospital located in the Shadyside neighborhood of Pittsburgh, Pennsylvania. UPMC Shadyside is a part of the University of Pittsburgh Medical Center (UPMC), and grouped in with the flagship UPMC Presbyterian. The hospital is near UPMC's flagship campus which houses Presbyterian and Montefiore. As the hospital is a teaching hospital, it is affiliated with University of Pittsburgh School of Medicine. The hospital has an emergency room to handle emergencies, with a rooftop helipad to transport critical patients to and from the hospital. UPMC Shadyside houses the flagship campus of the UPMC Hillman Cancer Center, a nationally ranked cancer hospital.Founded in as the Homeopathic Medical and Surgical Hospital and Dispensary, it changed its name to that of the neighborhood of Shadyside on May 12, 1938. Shadyside agreed to be bought by UPMC on June 5, 1996.

The Chancellor's Residence at the University of Pittsburgh is a Pittsburgh History and Landmarks Foundation Historic Landmark in Shadyside just east of the main Oakland campus approximately one half mile from the center of campus at the Cathedral of Learning and adjacent to the rear property of the University Child Development Center on the Oakland-Shadyside border in Pittsburgh, Pennsylvania.

The Western Pennsylvania Hospital, commonly referred to as "West Penn Hospital", is located at 4800 Friendship Avenue in the Bloomfield neighborhood of Pittsburgh, Pennsylvania. The 317-bed hospital is part of the Allegheny Health Network. It serves as a Clinical Campus of Temple University School of Medicine, offering medical education, including a large number of residency and fellowship programs. It is also the primary clinical setting of the West Penn Hospital School of Nursing.

The Church of the Ascension is an Anglican church located at Ellsworth Avenue and Neville Street in the Shadyside neighborhood of Pittsburgh, Pennsylvania. It was built in 1898. The church was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 1971.Like nearly all the Episcopal churches of the Pittsburgh area in the first half of the 20th century, the church boasted a really fine professional choir of men and boys that dominated the Sunday services, performing the music-heavy ritual of Morning Prayer from the 1928 Book of Common Prayer three Sundays out of four, the fourth Sunday being devoted to the celebration of Holy Communion. The choir's choral accomplishments peaked twice under the direction of Herbert C. Peabody in the 1930s and Robert Hamilton Cato in the 1940s. The church is currently a member of the Anglican Diocese of Pittsburgh, in the Anglican Church in North America.

The University Child Development Center (UCDC) at the University of Pittsburgh is a child care and early childhood education center located on Clyde Street in Shadyside just east of the main Oakland campus approximately one half mile from the center of campus at the Cathedral of Learning and adjacent to the rear property of the University's Chancellor's Residence on the Oakland-Shadyside border in Pittsburgh, Pennsylvania. The University acquired the building, the former First Church of Christ, Scientist, in the fall of 1992 for $1.015 million. In 1994, Pitt proceeded with a $2 million renovation of the building to accommodate the UCDC which opened its doors in the facility on May 30, 1995 after having previously been located in Bellefield Hall.The neo-classical-style building was designed by Solon Spencer Beman and built between 1904 and 1905. In 1977 it had been designated a local historic landmark by the Pittsburgh History and Landmarks Foundation,The University Child Development Center serves as a near-site child care and early childhood education center for children ranging in age from six weeks through six years who belong to the faculty, staff, and students of the University of Pittsburgh. The UCDC also provides laboratory, research, and practicum experiences in observing and participating with young children in classroom-based settings, for Pitt students, and students from other institutions of higher learning. The UCDC also provides resources and technical assistance in implementing appropriate programs and practices that serve young children in Pittsburgh and other communities.The UCDC facility houses classrooms including four infant rooms, four toddler rooms, two three-year-old preschool rooms, and two four to six-year-old preschool rooms. Each room is designed to be age-appropriate for the group occupying the space. The UCDC also includes two large motor rooms (one for infants and toddlers and the other for preschool children) and an outdoor playground facility.

The former First Church of Christ, Scientist is an historic Christian Science church building located at 635 Clyde Street, in the Shadyside section of Pittsburgh, Pennsylvania United States. Built in 1904, it was designed in the Classical Revival-style of architecture by noted Chicago architect Solon Spencer Beman.In 1977, First Church of Christ, Scientist, was designated a Pittsburgh Historic Landmark by the Pittsburgh History and Landmarks Foundation.The building was sold in 1992 to the University of Pittsburgh which has since renovated it for use as its University Child Development Center.In 2005 First Church of Christ, Scientist, was determined by the city of Pittsburgh's Historic Review Commission and the Department of City planning to be eligible for listing on the National Register of Historic Places.First Church of Christ, Scientist, now holds services at 201 North Dithridge at Bayard Street, in the Oakland section of Pittsburgh.

Rodef Shalom Congregation is a National Register of Historic Places landmark in Pittsburgh, Pennsylvania, designed by architect Henry Hornbostel.Located on Fifth Avenue on the border of the Oakland and Shadyside neighborhoods, it houses Congregation Rodef Shalom, the oldest Jewish congregation in Western Pennsylvania and the largest Reform congregation in the area. Across the street from the temple is the headquarters of Pittsburgh's PBS station WQED. On the grounds of the building is the Rodef Shalom Biblical Botanical Garden.

The Rodef Shalom Biblical Botanical Garden (0.3 acres) in Pittsburgh, Pennsylvania's Shadyside section is a Biblical botanical garden.Opened and free to the public since 1987 from June 1 through September 15. It was founded by Rabbi Walter Jacob and his wife horticulturalist Irene Jacob. It now displays more than 100 plants once grown in ancient Israel, including cedars, dates, figs, olives, and pomegranates. All are labeled with biblical verses, or their biblical name. The garden also includes a waterfall, desert, and a representation of the Jordan River from the Sea of Galilee to the Dead Sea. It produces a new show on ancient Near Eastern horticulture each summer.The garden is on the grounds of the Rodef Shalom Congregation, which houses Western Pennsylvania's oldest Jewish congregation, dating back to the 1840s.

Oakland Catholic High School is a private, Roman Catholic college preparatory school for girls, located in the Oakland neighborhood of Pittsburgh, Pennsylvania, United States, within the Diocese of Pittsburgh. It was established by Bishop Donald Wuerl in 1989 as the merger of former all-girl parish high schools of Sacred Heart and St. Paul Cathedral to serve as a sister school for Central Catholic. Approximately 600 students matriculate at Oakland Catholic and the school draws female students from all over the City of Pittsburgh and the suburbs. Upon graduation, 100% of its students continue to a four-year university. Oakland Catholic High School completed construction and renovations for the 2008-2009 school year.