Anacostia Riverwalk Trail

The Capital Crescent Trail (CCT) is a 7.04-mile (11.33 km), shared-use rail trail that runs from Georgetown in Washington, D.C., to Bethesda, Maryland. An extension of the trail from Bethesda to Silver Spring along a route formerly known as the Georgetown Branch Trail is being built as part of the Purple Line light rail project. The Capital Crescent Trail, one of the most heavily used rail trails in the United States, serves more than 1 million walkers, joggers, bikers, skateboarders and rollerbladers each year. In 2005, it was named one of the "21 great places that show how transportation can enliven a community" by The Project for Public Spaces.

The Talbot Avenue bridge in Montgomery County, Maryland, was a historic one-lane metal girder bridge that connected the neighborhood of Lyttonsville to downtown Silver Spring. Built in 1918 and dismantled in 2019, the bridge had historic value as a connection from an antebellum community founded by a free Black laborer to neighborhoods where for decades Black people were allowed to work, but not live.As of 2022, its main span is in storage with plans to display it along the Georgetown Branch Trail.

On February 16, 1996, a MARC commuter train collided with Amtrak's Capitol Limited passenger train in Silver Spring, Maryland, United States, killing three crew and eight passengers on the MARC train; a further eleven passengers on the same train and fifteen passengers and crew on the Capitol Limited were injured. Total damage was estimated at $7.5 million. An investigation by the National Transportation Safety Board (NTSB) found that the crew of the MARC train had forgotten the indication of an approach signal which they had passed before a station stop, and as a consequence, could not slow down in time after encountering a stop signal. The crash led to the creation of comprehensive federal rules for passenger car design, the first in the history of passenger service in the U.S., as well as changes to operating rules.

The Pilot Bioproduction Facility of the Walter Reed Army Institute of Research (WRAIR) is a Contract Manufacturing Organization (CMO) facility whose mission is to perform vaccine production on a pilot scale. The facility produces pre-license Phase I vaccine candidates under cGMP conditions using both bacterial and viral based technology. It is located at the Forest Glen Annex of the Walter Reed Army Institute of Research in Silver Spring, Maryland. Its business methodology is to work with government agencies through interagency agreements and with private companies through CRADAs (Cooperative Research and Development Agreements) in order to produce vaccine candidates. Its manufacturing capabilities include bacterial and viral seed banking, fermentation, purification (bacterial and viral proteins), and aseptic filling. The facility can perform whole campaigns from beginning to end or any individual function listed above under GMP conditions. The facility also has the capability to perform different viral titer assays on a contracted basis. The Facility has a Type V Facility Master File on file with the U.S. Food and Drug Administration.

The Forest Glen Annex is a 136-acre (0.55 km2) U.S. Army installation in the Forest Glen Park neighborhood of Silver Spring, Maryland, USA. It is situated between Brookville Road and Linden Lane. Since 1999, the Annex has been the site of the Walter Reed Army Institute of Research (WRAIR) and the Naval Medical Research Center (NMRC), along with smaller units. The Forest Glen property was acquired by the Army during the World War II era, and was formerly known as the “Walter Reed Forest Glen Annex”, a branch of the Walter Reed Army Medical Center (WRAMC) in Washington, DC.

Lyttonsville is a light rail station that is currently under construction in the Lyttonsville neighborhood of Silver Spring, Maryland. It will be part of the Purple Line in Maryland. The station will be located at Lyttonsville Place.

The Walter Reed Tropical Medicine Course (now called 'Operational Clinical Infectious Disease' Course ) at Walter Reed Army Institute of Research (WRAIR) is one of the many Tropical Medicine Training Courses available in the US and worldwide (see Tropical medicine). It is an intensive 5-day course and a 3-day short course, created to familiarize students with tropical diseases they may encounter overseas. The course is open to Physicians, Physician Assistants, Nurse Practitioners, ESO, 18D, or other medical personnel. The course is run by the military and designed for personnel of the US Military (Army, Marines, Navy, Air Force) and several other US government agencies.

The Walter Reed Army Institute of Research (WRAIR) is the largest biomedical research facility administered by the U.S. Department of Defense (DoD). The institute is centered at the Forest Glen Annex, in the Forest Glen Park part of the unincorporated Silver Spring urban area in Maryland just north of Washington, DC, but it is a subordinate unit of the U.S. Army Medical Research and Development Command (USAMRDC), headquartered at nearby Fort Detrick, Maryland. At Forest Glen, the WRAIR has shared a laboratory and administrative facility — the Sen Daniel K. Inouye Building, also known as Building 503 — with the Naval Medical Research Center since 1999. The Institute takes its name from Major Walter Reed, MD (1851–1902), the Army physician who, in 1901, led the team that confirmed the theory that yellow fever is transmitted by a particular mosquito species, rather than by direct contact. Today, the WRAIR fosters and performs biomedical research for the DoD and the US Army. It has recently developed two modern "Centers of Excellence" in the fields of military psychiatry/neuroscience and infectious disease research. The Centers focus, respectively, on soldier fitness, brain injury, and sleep management and in the development of vaccines and drugs for prevention and treatment of such diseases as malaria, HIV/AIDS, dengue fever, wound infections, leishmaniasis, enteric diseases.

16th Street–Woodside is a light rail station that is currently under construction in the Woodside neighborhood of Silver Spring, Maryland. It will be part of the Purple Line in Maryland. The station will be located at 16th Street.

The National Museum of Health and Medicine (NMHM) is a museum in Silver Spring, Maryland, near Washington, D.C. The museum was founded by U.S. Army Surgeon General William A. Hammond as the Army Medical Museum (AMM) in 1862; it became the NMHM in 1989 and relocated to its present site at the Army's Forest Glen Annex in 2011. An element of the Defense Health Agency (DHA), the NMHM is a member of the National Health Sciences Consortium.

North Portal Estates is an affluent residential neighborhood in Washington, D.C. that forms the northernmost corner of the District of Columbia. North Portal Estates is bounded by North Portal Drive to the south, East Beach Drive to the west and northwest, and Rock Creek Park to the northeast. It is not set on any major thoroughfare in the city, although North Portal Drive is accessible via a rotary intersection on 16th Street NW. Because of its isolation via the park and lack of major streets, the neighborhood is extraordinarily suburban in character, full of winding streets, detached houses on large lots, and open space. North Portal Estates and the rest of Ward 4 are represented in the Council of the District of Columbia by Janeese Lewis George. The community was mostly Jewish, in contrast to the nearby Colonial Village, which was a mostly Protestant neighborhood. The community was constructed by wealthy Jewish families in the 1950s and 1960s, following the 1948 Supreme Court decision striking down racially restrictive covenants. The homes in North Portal Estates are larger and more recent than the older homes in Shepherd Park. Racial covenants were prohibited by law by the 1968 Fair Housing Act. African-Americans began moving into North Portal Estates in the late 1960s and early 1970s, comprising two-thirds of the population by the 1980s as the older Jewish population began to move away or die. By the early 1980s, North Portal Estates had become a premier neighborhood for upper-middle-class African-American professionals in Washington, D.C., including doctors, lawyers, business people, clergy, and politicians. While mostly black, the neighborhood is multiracial as some white Jewish families have remained in the neighborhood. By the 2010s, the neighborhood was still predominantly upscale, but had become home to a more socioeconomically and racially mixed population.

WDDN-LD (channel 23) is a low-power religious television station in Washington, D.C., owned and operated by the Daystar Television Network. The station's transmitter is located on Brookville Road in Silver Spring, Maryland.