South Holyoke, Holyoke, Massachusetts

The Friedrich Block is a historic mixed-use commercial and residential block at 449-461 Main Street (the corner with Sargeant Street) in Holyoke, Massachusetts. Built in 1908, it is a significant Renaissance Revival work by the local architect George P. B. Alderman, and for its association with the E.H. Friedrich Company, a manufacturer of metal architectural parts. The building was listed on the National Register of Historic Places in 2002.

Precious Blood Church of Holyoke, Massachusetts, burned on May 27, 1875, killing 78 people. The fire started at the front of the church as a candle flame ignited a curtain. There was a crush of people through the entrance at the back left and many people could not leave. It is one of the deadliest fires in American history, and was also known by newspapers domestic and foreign as "The Holyoke Disaster".Panic caused people to rush from the upper levels to a front door. The door was made to open inward only so many were trapped against the door. Reverend Andre Dufresne was the parish priest. He tried to calm the people and direct them as much as possible. A list of the dead is given below by first and last name and then age. Many were buried in a common grave on May 29 at the Precious Blood Cemetery in South Hadley. All were French Canadians. The wooden church had been built in 1870 and was replaced in 1876 by a brick church. There is a monument for the dead at the cemetery. The parish priest was also reburied there. The names have been taken directly from the monument. The names were determined from the Holyoke Deaths Register and from various newspaper articles. The accuracy is very high but there might still be small errors since there was a language barrier from the French immigrants to the English speaking officials and newspaper writers. Also the chaos of the days after the burning of the church was very high. One obvious correction that can be made in the future is seen in that French would use Marie and Celine and never Mary and Selina.The church complex is located on the city block formed by Cabot, South East, Clemente, and Hamilton Streets. Only the convent and rectory remain today since the brick church and school were dismantled. The Park Street School was located on the other side of Hamilton Street between Park and South East Streets. The school was used as a temporary morgue for the fire victims. The cemetery is on Willimansett Street Extension near the intersection of Routes 33 and 202 in South Hadley. The black memorial is in the center of the cemetery and the priest is buried behind that. The event and its aftermath were also later depicted in some detail in the Franco-American novel Mirbah by Emma Port-Joli Dumas, originally published in Holyoke's La Justice.

The Clovis Robert Block is a historic mixed-use commercial and residential block at 338-348 Main Street (the corner of Cabot Street) in south Holyoke, Massachusetts. Built in 1881 and enlarged in 1888, it is a prominent early example of the work of local architect George P. B. Alderman, and is representative of development patterns in the city that served its growing French Canadian immigrant community. The building was listed on the National Register of Historic Places in 2002.

The Holyoke Testing Flume was a hydraulic testing laboratory and apparatus in Holyoke, Massachusetts, operated by the Holyoke Water Power Company from 1870 to 1932, and used to test the performance of water turbine designs, completing 3,176 tests of efficiency in that time.: 100  It was described by Robert E. Horton in court testimony as the only facility of its kind in the 19th and early 20th century, which made possible the standardization of American water turbines. Indeed Clemens Herschel, who managed and redesigned the facility in the 1880s, later described it in Congressional testimony as the "first modern hydraulic laboratory" in the United States and the world. It was through Herschel's need to determine the water power consumption of different mills, and in this testing system that he would invent the Venturi meter, the first accurate means of measuring large-scale flows, which still retains widespread use in modern technology today.

Massachusetts Green High Performance Computing Center (MGHPCC) is an intercollegiate high-performance computing facility located in Holyoke, Massachusetts, connected to that city's municipal fiber grid and powered by Holyoke Gas and Electric via the Holyoke Canal System and Dam. MGHPCC is a joint venture of Boston University, Harvard, MIT, Northeastern, and the University of Massachusetts system; the facility holds the capacity for hundreds of thousands of cores in clusters provided by its affiliates. For example, as of 2016 one cluster used by UMass contained a network of 14,376 cores, both Intel and AMD, and more than 1.1 petabytes of on-site storage on an FDR Infiniband network. The facility maintains capacity for regular expansion, with key partners investing capability upgrades in the current building and more than 4 acres of additional undeveloped space.

The Willimansett Bridge is a steel truss bridge over the Connecticut River located between Chicopee, Massachusetts and Holyoke, Massachusetts. It carries Massachusetts state routes 116 and 141.

The Maplewood Hotel is a historic residential hotel at 328-330 Maple Street in Holyoke, Massachusetts. Consisting of two buildings dating to the late 19th century, it was the first residential building of its type in the city, built by local industrialist Frank Beebe, who occupied one of its units. When opened, it offered high quality furnished and unfurnished residences in a full-service environment. The hotel was listed on the National Register of Historic Places in 1983. It continues to be used for residences.

Churchill is a neighborhood in Holyoke, Massachusetts located to the south of the city center, adjacent to the downtown. Its name is a geographic portmanteau as the area was historically known as the Church Hill district prior to its extensive development in the early twentieth century. Located at the southwestern edge of the downtown grid, the area served as housing for mill workers in the late nineteenth and early twentieth century and today contains 166 acres (67 ha) of mixed residential and commercial zoning, including a number of historical brick tenements as well as the headquarters of the Holyoke Housing Authority, Holyoke Senior Center, Churchill Homes public housing, and the Wistariahurst Museum.

Holyoke Heritage State Park is history-oriented state park located in the city of Holyoke, Massachusetts. The park opened in 1986 on the site of the William Skinner Silk Mill which was lost to fire in 1980. The park is managed by the Massachusetts Department of Conservation and Recreation.

Holyoke station is an Amtrak intercity train station near the corner of Main and Dwight streets in Holyoke, Massachusetts, United States. The station opened on August 27, 2015, eight months after Amtrak's Vermonter service was re-routed to the Connecticut River Line through the Pioneer Valley. The first railroad station in Holyoke had opened in 1845, followed by the H.H. Richardson-designed Connecticut River Railroad Station in 1885. Though passenger service to Holyoke ended in 1966, the 1885 depot is still extant. The opening of the new station returned passenger rail service to Holyoke for the first time in 49 years, and to the Dwight and Main streets site for the first time in 130 years. A pilot program added two daily Amtrak Shuttle round trips in August 2019 under the Valley Flyer moniker.

The War Memorial Building is a historic municipal building at 310 Appleton Street in Holyoke, Massachusetts. Built in 1936, it is a distinctive local example of Moderne architecture, and a memorial to the city's military veterans. It houses an auditorium as well as smaller meeting spaces and offices. The building was listed on the National Register of Historic Places in 2022.

The International Volleyball Hall of Fame (IVHF) was founded to honor extraordinary players, coaches, officials, and leaders who have made significant contributions to the game of volleyball. The Hall of Fame is located in Holyoke, Massachusetts, where volleyball was invented in 1895 by William G. Morgan at the local YMCA.