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Tramezzini NYC is a family-owned sandwich shop and Italian eatery in New York City that was the first to serve authentic Venetian sandwiches in the United States.

Le Petit Versailles is a New York City community garden in the Lower East Side neighborhood. It was established in 1996 by artists Peter Cramer and Jack Waters, who wanted to create a queer public space in the city. The garden is a part of the NYC Department of Park's GreenThumb program. The garden regularly holds calls for proposals for artistic works or events and hosts community events such as exhibitions, readings, live performances, and film screenings.

The Clinton Street Baking Company & Restaurant (CSBC) is an American bakery and restaurant. It is located at 4 Clinton Street (between East Houston Street and Stanton Street), on the Lower East Side of Manhattan, New York.The restaurant is noted especially for its pancakes, its burgers, and its biscuits and other fresh-baked goods. In December 2010, The New York Times described it as a "brunch magnet", and The New York Daily News said the "legendary" dining destination was "the city's hottest breakfast nook". Time called it a "cult favorite". In 2011, Poor Taste Magazine rated it # 1 in its list of the 100 Best Brunch Spots in America.

Congregation Chasam Sopher is an Orthodox synagogue located at 10 Clinton Street on the Lower East Side of Manhattan. It was formed in 1892 by the merger of two congregations of immigrants from Poland. It occupies a historic Romanesque Revival synagogue building built in 1853 by Congregation Rodeph Sholom. It is among the oldest synagogue buildings still standing in the United States, the second-oldest synagogue building in New York, and the oldest still in use in the state.Renovation of the upstairs, completed in 2006, included conservation of the Torah ark, the installation of new stained-glass windows, and stripping the interior of paint to expose the original wood. The outside was also landscaped, creating a garden for the neighborhood.As of 2011, the rabbi was Azriel Siff.

The Old Reliable Theatre Tavern (or The O.R.) was located at 213 E. 3rd Street in the Alphabet City neighborhood of New York City's Lower East Side, and played a vital part of the early Off-Off-Broadway scene. The Old Reliable presented plays by Guy Gauthier, Ilsa Gilbert, William M. Hoffman, Michael McGrinder, Stanley Nelson, Jeannine O'Reilly, Robert Patrick, Joseph Renard, Donald Kvares and Thomas Terefenko.The Old Reliable was initially a working-class Polish bar, until late 1963 when the owner sought to turn it into a "Village bar", with the advice of a passing hipster. The neighborhood around the Old Reliable was dangerous during its heyday; popular actor/director Neil Flanagan quipped, "It's easy to find. Just turn left at the burning automobile." Playwright Jeannine O'Reilly said, "It's no wonder we get such good audiences. Everyone's afraid to come here alone." Robert Patrick described the neighborhood as "downtown Lebanon". There was for a period of time a Second Avenue bar called Downtown Beirut.

Stanton Street Synagogue, also known as Stanton Street Shul and Congregation Bnai Jacob Anshei Brzezan (Yiddish: קאנגרעגיישאן בני יעקב אנשי ברזעזאן, "Congregation Sons of Jacob, People of Brzezan"), is a historic synagogue located at 180 Stanton Street on the Lower East Side of Manhattan, New York. It was constructed in 1913 by a landsmanshaft from the town of Brzeżany in southeast Galicia. The first Rabbi of the congregation, in their first building, was Rabbi Judah Leib Rose (1867-1946). He had arrived in New York in 1909 and encouraged the congregation to build the Shul on Stanton Street. One of the few surviving tenement-style synagogues, it was listed on the National Register of Historic Places in 2002. That same year, the synagogue's congregants went to court over an attempt by its rabbi and board members to sell the aging structure to an organization run by a Jesuit priest. The resultant settlement and media attention led to a resurgence in interest in the synagogue. In 2012 its membership stands at about 100 congregants, representing a wide, intergenerational mix. The Stanton Street Synagogue was founded as a traditional, or Orthodox, house of worship and remains so until today.

Colors was a 70-seat restaurant in the Lower East Side of Manhattan, New York City. The September 11 attacks on the World Trade Center destroyed the popular Windows on the World restaurant, and, when many of its former workers remained unemployed a non-profit started a restaurant named Colors to employ them, while upgrading their skills.

Ivan Ramen is a ramen restaurant in New York City (25 Clinton Street, Lower East Side) which is run by chef Ivan Orkin.

The Nuyorican (Puerto Rican New Yorkers) Poets Cafe is a nonprofit organization in Alphabet City, on the Lower East Side of Manhattan. It is a bastion of the Nuyorican art movement in New York City, and has become a forum for poetry, music, hip hop, video, visual arts, comedy, and theater. Several events during the PEN World Voices festival are hosted at the cafe.The Café is meant to be a shooting-off point from which Nuyorican artists, poets, and playwrights take shared themes and messages of community, understanding, and the breaking down of arbitrary separators of color, among others, and spread them outside the environment of the Café.

Economy Candy is a candy store in the Lower East Side New York City. It was established in 1937. The managers are the Cohen family.Serious Eats described Economy Candy as the craziest and best candy store in New York City.The store celebrated its 85th anniversary in July 2022.Economy Candy stocks many branded candies, including older brands which are difficult to find elsewhere.The Cohen family who owns the store also has a history of themselves working at the store.In February 2023 the store announced its first expansion location, which will be in the Chelsea Market.

The Metropolitan Playhouse is a resident producing theater in New York City's East Village. Founded in 1992, the theater is devoted to presenting plays that explore American culture and history, including seldom-produced, "lost" American plays and new plays about or derived from American history and literature. Included among its best known revivals are Abram Hill's On Strivers Row, Owen Davis's Pulitzer Prize winning Icebound, George L. Aiken's adaptation of Uncle Tom's Cabin, Jacob Gordin's The Jewish King Lear (in a translation by Ruth Gay), The Great Divide by William Vaughn Moody, The Drunkard by W. H. Smith, Inheritors by Susan Glaspell, The Melting Pot by Israel Zangwill, The City by Clyde Fitch, Metamora by John Augustus Stone, Sun-Up by Lula Vollmer, and The New York Idea by Langdon Mitchell, and numerous early one-act plays by Eugene O'Neill. The company has also staged three 'Living Newspapers' from the Federal Theater Project: Arthur Arent's Power in 2007, One-Third of a Nation in 2011, and Injunction Granted in 2015. During the first 15 months of the COVID-19 pandemic, the playhouse presented weekly readings online of American plays and short stories, as well as occasional concerts and improvised performance including the work of Zero Boy, the Area 9 Quartet, Amanda Selwyn Dance, all as a part of its Virtual Playhouse series. Metropolitan has been led by Producing Artistic Director Alex Roe since 2001.

The Connelly Theater is an Off-Broadway theatre at 220 E 4th St in the East Village area of Manhattan. It was originally built in the 1860s as the choir hall for an orphanage.