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Stanton Street Synagogue, also known as Stanton Street Shul and Congregation Bnai Jacob Anshei Brzezan (Yiddish: קאנגרעגיישאן בני יעקב אנשי ברזעזאן, "Congregation Sons of Jacob, People of Brzezan"), is a historic synagogue located at 180 Stanton Street on the Lower East Side of Manhattan, New York. It was constructed in 1913 by a landsmanshaft from the town of Brzeżany in southeast Galicia. The first Rabbi of the congregation, in their first building, was Rabbi Judah Leib Rose (1867-1946). He had arrived in New York in 1909 and encouraged the congregation to build the Shul on Stanton Street. One of the few surviving tenement-style synagogues, it was listed on the National Register of Historic Places in 2002. That same year, the synagogue's congregants went to court over an attempt by its rabbi and board members to sell the aging structure to an organization run by a Jesuit priest. The resultant settlement and media attention led to a resurgence in interest in the synagogue. In 2012 its membership stands at about 100 congregants, representing a wide, intergenerational mix. The Stanton Street Synagogue was founded as a traditional, or Orthodox, house of worship and remains so until today.

Colors was a 70-seat restaurant in the Lower East Side of Manhattan, New York City. The September 11 attacks on the World Trade Center destroyed the popular Windows on the World restaurant, and, when many of its former workers remained unemployed a non-profit started a restaurant named Colors to employ them, while upgrading their skills.

The Clinton Street Baking Company & Restaurant (CSBC) is an American bakery and restaurant. It is located at 4 Clinton Street (between East Houston Street and Stanton Street), on the Lower East Side of Manhattan, New York.The restaurant is noted especially for its pancakes, its burgers, and its biscuits and other fresh-baked goods. In December 2010, The New York Times described it as a "brunch magnet", and The New York Daily News said the "legendary" dining destination was "the city's hottest breakfast nook". Time called it a "cult favorite". In 2011, Poor Taste Magazine rated it # 1 in its list of the 100 Best Brunch Spots in America.

Congregation Chasam Sopher is an Orthodox synagogue located at 10 Clinton Street on the Lower East Side of Manhattan. It was formed in 1892 by the merger of two congregations of immigrants from Poland. It occupies a historic Romanesque Revival synagogue building built in 1853 by Congregation Rodeph Sholom. It is among the oldest synagogue buildings still standing in the United States, the second-oldest synagogue building in New York, and the oldest still in use in the state.Renovation of the upstairs, completed in 2006, included conservation of the Torah ark, the installation of new stained-glass windows, and stripping the interior of paint to expose the original wood. The outside was also landscaped, creating a garden for the neighborhood.As of 2011, the rabbi was Azriel Siff.

Ivan Ramen is a ramen restaurant in New York City (25 Clinton Street, Lower East Side) which is run by chef Ivan Orkin.

wd~50 was a molecular gastronomy New American/international restaurant in Manhattan, New York City. It was opened in 2003 by chef Wylie Dufresne. wd-50 closed 30 November 2014.

Tramezzini NYC is a family-owned sandwich shop and Italian eatery in New York City that was the first to serve authentic Venetian sandwiches in the United States.

The 124 Ridge Street Gallery was a collective gallery founded in New York's Lower East Side in 1985. Founding members were Susan Bachemin, Elizabeth Evers, Jane Fine, Matthew Harrison, Michael Kaniecki, Robert McGrath, Heidi Marben, Laurie Olinder, and Joe Vinson. Subsequent members included Amy Berniker, Ruth Pomerantz, Paul Rodriguez, Roger W. Sayre, Ann Shea, Paul Villinski and Carla Weisberg. The gallery exhibited art and film from local artists and filmmakers during the 1980s East Village art gallery scene, including Matty Jankowski's 1987 mail art show "The Joke is in the Mail." The film screening series Film Crash was founded at the gallery. The gallery was closed in 1997.

Rivington Arms was an art gallery in New York City. Melissa Bent and Mirabelle Marden (daughter of artists Helen and Brice Marden) founded the gallery as a small storefront on Rivington Street in 2001, part of a new wave of galleries opening in the Lower East Side. In 2005, it moved to a larger space on East 2nd Street.The gallery participates in the following art fairs: The Armory Show, Frieze, NADA, and VOLTAshow. It was announced on November 5, 2008 in Artforum that due to business differences, Rivington Arms would be closing its location in January 2009 after they attended the Frieze Art Fair in London.

The Church of Our Lady of Sorrows (Spanish: Nuestra Señora de los Dolores) is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located at 105 Pitt Street between Rivington Street and Stanton Street in the Lower East Side of Manhattan in New York City. The area formerly served Catholics who lived in the immigrant enclave of Kleindeutschland (Little Germany).

63 Clinton (sometimes Sixty Three Clinton) is a restaurant in New York City. The restaurant has received a Michelin star.

WhiteBox is a non-profit art space located in New York City. It hosts contemporary exhibitions, performance, video and special events including readings, lectures and panel discussions.