Savoy Ballroom

The Church of St. Mark the Evangelist is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located at West 138th Street, near Lenox Avenue in northern Harlem, Manhattan, New York City. The address is 59-61 West 138th Street and 195 East Lenox Avenue. The parish was established in 1907 and has been staffed by the Holy Ghost Fathers since 1912. The Rev. Charles J. Plunkett, pastor, had a brick church built in 1914 to designs by Nicholas Serracino of 1170 Broadway for $12,000.

The Cotton Club was a New York City nightclub from 1923 to 1940. It was located on 142nd Street and Lenox Avenue (1923–1936), then briefly in the midtown Theater District (1936–1940). The club operated during the United States' era of Prohibition and Jim Crow era racial segregation. Black people initially could not patronize the Cotton Club, but the venue featured many of the most popular black entertainers of the era, including musicians Fletcher Henderson, Duke Ellington, Jimmie Lunceford, Chick Webb, Louis Armstrong, Count Basie, Fats Waller, Willie Bryant; vocalists Adelaide Hall, Ethel Waters, Cab Calloway, Bessie Smith, Aida Ward, Avon Long, the Dandridge Sisters, the Will Vodery Choir, The Mills Brothers, Nina Mae McKinney, Billie Holiday, Midge Williams, Lena Horne, and dancers such as Katherine Dunham, Bill Robinson, The Nicholas Brothers, Charles 'Honi' Coles, Leonard Reed, Stepin Fetchit, the Berry Brothers, The Four Step Brothers, Jeni Le Gon and Earl Snakehips Tucker. At its prime, the Cotton Club served as a hip meeting spot, with regular "Celebrity Nights" on Sundays featuring guests such as Jimmy Durante, George Gershwin, Sophie Tucker, Paul Robeson, Al Jolson, Mae West, Richard Rodgers, Irving Berlin, Eddie Cantor, Fanny Brice, Langston Hughes, Judy Garland, Moss Hart, and Jimmy Walker, among others.

Harlem Hospital School of Nursing was a training school for African-American women, which was established at Harlem Hospital in Harlem, New York City in 1923. It was founded due to the lack of nursing schools in New York that accepted African American women. Until 1923, the Lincoln Hospital School for Nurses in The Bronx was the only school that allowed the enrollment of Black women. When Mayor Hylan sought reelection in 1921, the NAACP and other community organizations lobbied the mayor to improve healthcare access. Around the same time, Lurline Vassall of Brooklyn, was denied entry to the Bellevue Hospital School of Nursing because of her race. Lurline's father William Vassall launched a campaign to open a school for black nurses. In response, Hylan's administration supported the creation of the Harlem Hospital School of Nursing.The school opened on January 3, 1923, with a class of twenty black women. It was a two and a half year program.The Harlem Hospital School of Nursing closed in 1977.

The 369th Regiment Armory is a historic National Guard Armory building located at 2366 Fifth Avenue, between West 142nd and 143rd Streets, in Harlem, Manhattan, New York City. It was built for the 369th Regiment, also known as the "Harlem Hellfighters", founded in 1913 as the first National Guard unit in New York State composed solely of African-Americans. It later became home to the 369th Sustainment Brigade. The 369th Regiment Armory includes two structures. The administration building, built in the Art Deco style between 1930 and 1933, was designed by John S. Van Wart and Sidney Wein. The attached medieval-inspired drill shed, built between 1921 and 1924, was designed by Tachau and Vought and measures 50,000 square feet (4,600 m2). Both sections are constructed of brick. The armory was listed on the National Register of Historic Places in 1994, and was designated as a city landmark by the New York City Landmarks Preservation Commission in 1985.

The 145th Street station is a station on the IRT Lenox Avenue Line of the New York City Subway. Located at the intersection of 145th Street and Lenox Avenue in Harlem, Manhattan, it is served by the 3 train at all times. Built for the Interborough Rapid Transit Company (IRT), the 145th Street station contains two side platforms that can only fit six and a half train cars, unlike almost all other IRT stations, which are able to fit full-length ten-car trains. The station opened in 1904 as one of the northern termini of the original subway line operated by the IRT. With the construction of the Harlem–148th Street station to the north in the 1960s, the 145th Street station was planned to be closed, but due to community opposition, and passengers' protests, the station remained open. Since the 145th Street station is the second-to-last stop on the line, entry is provided only to the southbound platform, although northbound customers are allowed to exit from this station. The station was added to the National Register of Historic Places in 2005, and was closed from July to November 2018 for extensive renovations. The 145th Street station contains two side platforms and two tracks. The station was built with tile and mosaic decorations. The platforms contain exits to Lenox Avenue's intersection with 145th Street and are not connected to each other within fare control.

The Abyssinian Baptist Church is a Baptist megachurch located at 132 West 138th Street between Adam Clayton Powell Jr. Boulevard and Lenox Avenue in the Harlem neighborhood of Manhattan, New York City. It is affiliated with the National Baptist Convention, USA and American Baptist Churches USA. Its senior pastor is Johnnie D. Brooker, Jr.. The Abyssinian Baptist Church congregation traces its history to 1809, when seamen from the Ethiopian Empire (then known as Abyssinia) helped lead a protest against racially segregated church seating. Thomas Paul was an early minister. During the 20th century, prominent ministers of the church included Adam Clayton Powell Sr., Adam Clayton Powell Jr., and Samuel DeWitt Proctor. The church has served as an influential place for African-American spirituality, politics and community. The church worshiped in several places before building the present church structure Its present building was built in 1922–23 and was designed by Charles W. Bolton & Son in Gothic Revival and Tudor Revival styles – it has also been described as "Collegiate Gothic". It features stained glass windows and marble furnishings. The church and its associated community house were designated a New York City Landmark on July 13, 1993.

Harlem Hospital Center, branded as NYC Health + Hospitals/Harlem, is a 272-bed, public teaching hospital affiliated with Columbia University. It is located at 506 Lenox Avenue in Harlem, Manhattan, New York City and was founded in 1887.The hospital was established to provide healthcare to the citizens of the neighborhood. Initially, the hospital served as a holding area for patients to be transferred to Randalls and Wards Islands and Bellevue Hospital. With the wave of the African Americans who moved to New York after World War I, the hospital soon outgrew its initial building. After acquiring land, a new building opened on April 13, 1907. The hospital developed a teaching program that is affiliated with Columbia University, and has continued to serve the Harlem neighborhood since its inception.

The Dark Tower was a townhouse on 108 West 136th Street in Harlem.

The Mother African Methodist Episcopal Zion Church, also known as "Mother Zion", located at 140–148 West 137th Street between Adam Clayton Powell Jr. Boulevard and Lenox Avenue in the Harlem neighborhood of Manhattan, New York City, is the oldest African-American church in New York City, and the "mother church" of the African Methodist Episcopal Zion conference.The church was designated a New York City Landmark on July 13, 1993.

The Renaissance Ballroom & Casino was an entertainment complex at 2341–2349 Adam Clayton Powell Jr. Boulevard (Seventh Avenue) in the Harlem neighborhood of Manhattan in New York City. When opened in 1921, it included a casino, ballroom, 900-seat theater, six retail stores, and a basketball arena. It spanned the entire eastern frontage of Adam Clayton Powell Jr. Boulevard between 137th and 138th Streets.

The Greater Hood Memorial AME Zion Church was the first black church in Harlem, New York. It now receives notoriety as the "Oldest Continuing" church in Harlem. The church’s first house of worship was erected on East 117th Street, between 2nd and 3rd Avenues in 1843.

The Schomburg Center for Research in Black Culture is a research library of the New York Public Library (NYPL) and an archive repository for information on people of African descent worldwide. Located at 515 Malcolm X Boulevard (Lenox Avenue) between West 135th and 136th Streets in the Harlem neighborhood of Manhattan, New York City, it has, almost from its inception, been an integral part of the Harlem community. It is named for Afro-Puerto Rican scholar Arturo Alfonso Schomburg. The resources of the center are broken up into five divisions, the Art and Artifacts Division, the Jean Blackwell Hutson General Research and Reference Division, the Manuscripts, Archives and Rare Books Division, the Moving Image and Recorded Sound Division, and the Photographs and Prints Division. In addition to research services, the center hosts readings, discussions, art exhibitions, and theatrical events. It is open to the general public.