Mother African Methodist Episcopal Zion Church

The Abyssinian Baptist Church is a Baptist megachurch located at 132 West 138th Street between Adam Clayton Powell Jr. Boulevard and Lenox Avenue in the Harlem neighborhood of Manhattan, New York City. It is affiliated with the National Baptist Convention, USA and American Baptist Churches USA. Its senior pastor is Johnnie D. Brooker, Jr.. The Abyssinian Baptist Church congregation traces its history to 1809, when seamen from the Ethiopian Empire (then known as Abyssinia) helped lead a protest against racially segregated church seating. Thomas Paul was an early minister. During the 20th century, prominent ministers of the church included Adam Clayton Powell Sr., Adam Clayton Powell Jr., and Samuel DeWitt Proctor. The church has served as an influential place for African-American spirituality, politics and community. The church worshiped in several places before building the present church structure Its present building was built in 1922–23 and was designed by Charles W. Bolton & Son in Gothic Revival and Tudor Revival styles – it has also been described as "Collegiate Gothic". It features stained glass windows and marble furnishings. The church and its associated community house were designated a New York City Landmark on July 13, 1993.

The Renaissance Ballroom & Casino was an entertainment complex at 2341–2349 Adam Clayton Powell Jr. Boulevard (Seventh Avenue) in the Harlem neighborhood of Manhattan in New York City. When opened in 1921, it included a casino, ballroom, 900-seat theater, six retail stores, and a basketball arena. It spanned the entire eastern frontage of Adam Clayton Powell Jr. Boulevard between 137th and 138th Streets.

The Dark Tower was a townhouse on 108 West 136th Street in Harlem.

The James Weldon Johnson Residence is a historic apartment house located at 187 West 135th Street, Harlem, Manhattan, New York City, New York. It is here where James Weldon Johnson (1871-1938) lived from 1925 until his death. In addition to being a composer, songwriter, and author, he was an outspoken advocate for civil rights, working in various roles at the NAACP, including as its General Secretary during his residency here. The building was declared a National Historic Landmark in 1976.

The Schomburg Center for Research in Black Culture is a research library of the New York Public Library (NYPL) and an archive repository for information on people of African descent worldwide. Located at 515 Malcolm X Boulevard (Lenox Avenue) between West 135th and 136th Streets in the Harlem neighborhood of Manhattan, New York City, it has, almost from its inception, been an integral part of the Harlem community. It is named for Afro-Puerto Rican scholar Arturo Alfonso Schomburg. The resources of the center are broken up into five divisions, the Art and Artifacts Division, the Jean Blackwell Hutson General Research and Reference Division, the Manuscripts, Archives and Rare Books Division, the Moving Image and Recorded Sound Division, and the Photographs and Prints Division. In addition to research services, the center hosts readings, discussions, art exhibitions, and theatrical events. It is open to the general public.

The Harlem YMCA is located at 180 West 135th Street between Lenox Avenue and Adam Clayton Powell Jr. Boulevard in the Harlem neighborhood of Manhattan, New York City. Built in 1931-32, the red-brown brick building with neo-Georgian details was designed by the Architectural Bureau of the National Council of the YMCA, with James C. Mackenzie Jr. as the architect in charge. It replaced the building from 1919 across the street. Inside the building is a mural by Aaron Douglas titled "Evolution of Negro Dance." The building was declared a National Historic Landmark in 1976, and was designated a New York City Landmark in 1998.

The 135th Street station is a station on the IRT Lenox Avenue Line of the New York City Subway. Located at the intersection of 135th Street and Lenox Avenue in Harlem, it is served by the 2 and 3 trains at all times. The 135th Street station was constructed for the Interborough Rapid Transit Company (IRT) as part of the city's first subway line, which was approved in 1900. Construction on the tunnel segment that includes the 135th Street station started on October 2 of the same year. The station opened on November 23, 1904. The station platforms were lengthened in 1910. The 135th Street station contains two side platforms and three tracks. The station was built with tile and mosaic decorations. The platforms contain exits to Lenox Avenue's intersection with 135th Street and are not connected to each other within fare control. The platforms contain elevators from the street, which make the station compliant with the Americans with Disabilities Act of 1990.

Harlem Hospital Center, branded as NYC Health + Hospitals/Harlem, is a 272-bed, public teaching hospital affiliated with Columbia University. It is located at 506 Lenox Avenue in Harlem, Manhattan, New York City and was founded in 1887.The hospital was established to provide healthcare to the citizens of the neighborhood. Initially, the hospital served as a holding area for patients to be transferred to Randalls and Wards Islands and Bellevue Hospital. With the wave of the African Americans who moved to New York after World War I, the hospital soon outgrew its initial building. After acquiring land, a new building opened on April 13, 1907. The hospital developed a teaching program that is affiliated with Columbia University, and has continued to serve the Harlem neighborhood since its inception.

Smalls Paradise (often called Small's Paradise and Smalls' Paradise, and not to be confused with Smalls Jazz Club), was a nightclub in Harlem, New York City. Located in the basement of 2294 Seventh Avenue at 134th Street, it opened in 1925 and was owned by Ed Smalls (né Edwin Alexander Smalls; 1882–1976). At the time of the Harlem Renaissance, Smalls Paradise was the only one of the well-known Harlem night clubs to be owned by an African-American and integrated. Other major Harlem night clubs admitted only white patrons unless the person was an African-American celebrity. The entertainment at Smalls Paradise was not limited to the stage; waiters danced the Charleston or roller-skated as they delivered orders to customers. Waiters were also known to vocalize during the club's floor shows. Unlike most of the Harlem clubs which closed between 3 and 4 am, Smalls was open all night, offering a breakfast dance which featured a full floor show beginning at 6 am. After 23 years as the owner of the night club, Ed Smalls sold the club to Tommy Smalls (no relation) in 1955. It was later owned by Harlem businessman Pete McDougal and Wilt Chamberlain, and renamed Big Wilt's Smalls Paradise. Many well known musicians, both white and African-American, appeared at the club over the years and often came to Smalls after their evening engagements to jam with the Smalls Paradise band. The club was responsible for promoting popular dances such as the Charleston, the Madison and the Twist. Smalls Paradise was the longest-operating club in Harlem before it closed in 1986. The building has been the site of Thurgood Marshall Academy since 2004.

The Will Marion Cook House is a historic townhouse at 221 West 138th Street, in the part of Harlem known as Strivers' Row in Manhattan, New York City. It was the home of Will Marion Cook (1869-1944), a leading African-American musician and composer of the period, from 1918 until his death in 1944. Cook was a major influence on later musicians including Sidney Bechet, Duke Ellington, and Josephine Baker. It was declared a National Historic Landmark in 1976.

Florence Mills House is a house at 220 West 135th Street in Harlem, Manhattan, New York City. The house was originally believed to be the residence of Florence Mills, a leading African-American actress and entertainer during the 1920s. She lived at this address, or a similar address a few blocks away, during her most productive years from 1910 to 1927. The 220 West 135th Street building that existed in 1927 no longer stands and has been replaced. The site was designated a National Historic Landmark in 1976.The designation was withdrawn in January 2009. The actual address of her home was 220 West 133rd Street; the mistake was perpetuated because a photo of the house was mislabelled as being on West 135th Street in a New York Evening Journal article at the time of her death. The 220 West 133rd Street building has also been demolished and replaced. The mistake in landmarking the West 135th Street address is acknowledged implicitly by the National Park Service, in stating that "For a number of years, this four-story row house was thought to be Mills home for most of her tragically short life."

Thurgood Marshall Academy for Learning and Social Change is a public middle and high school in New York City serving grades 6 to 12. It is named for United States Supreme Court Justice Thurgood Marshall. The school is at 200-214 W 135th Street in Harlem. The school opened in 1993 with Harriet Pitts as principal.The school's student body is 70 percent African American and 26 percent Hispanic. About 70 percent are from economically disadvantaged families.After moving four times in its first 11 years, it moved into a new $38 million 6-story 90,000 square foot school building in 2004. Thurgood Marshall's wife Cecilia Marshall was among the dignitaries to attend opening ceremonies for the new school building.Calvin Butts III and the Abyssinian Development Corporation (ADC) were involved in founding the school.Retailer Burlington helped fund a 2017 renovation of the school's library. In 2017, a teacher at the school was charged with assault after allegedly grabbing a 17-year-old female student by the neck.