B'nai Israel Synagogue and Cemetery

The Lapham–Patterson House is a historic site at 626 North Dawson Street in Thomasville, Georgia. The house, built between 1884-85 as a winter cottage for businessman C.W. Lapham of Chicago, is a significant example of Victorian architecture. It has a number of architectural details, such as fishscale shingles, an intricately designed porch, long-leaf pine inlaid floors, and a double-flue chimney. Inside, the house was well-appointed with a gas lighting system, hot and cold running water, indoor plumbing, and modern closets. Its most significant feature is its completely intentional lack of symmetry. None of the windows, doors, or closets are square. The house is a Georgia Historic Site and is also a National Historic Landmark, designated in 1973 for its architecture. It is also a contributing building in the National Register-listed Dawson Street Residential Historic District. The three-story structure has a mellow-yellow exterior with brick-red roof and chimneys. At the core of the house is a hexagonal-shaped room. There are at least 50 exits; Mr. Lapham had been in the Great Chicago Fire and subsequently became paranoid about being trapped in a burning building. The house was deliberately constructed slightly askew to take advantage of sunlight entering the third floor during the Spring and Fall Equinoxes. Within is a gentlemen's parlor with a small stage featuring a stained-glass window in the center. In the fretwork outside the room over the balcony are animal and amorphous shapes cut into the wood. In the center is a cutout of what is presumably the head of Mrs. O'Leary's cow. During the Spring and Fall Equinoxes the patterns are projected by sunlight onto the floor through the glass. The total effect is that, in the center of the stained glass window's colorful pattern on the floor, the shadow of the cow's head can be seen. Mr. Lapham was a Quaker.

The Dawson Street Residential Historic District, in Thomasville, Georgia, is a 200-acre (0.81 km2) historic district which was listed on the National Register of Historic Places in 1984. It then included 380 contributing buildings and three contributing sites. It is located to the north of the city's commercial center and its courthouse square. As well as houses, the district includes several churches, two historic cemeteries (one for whites and one for blacks), a historic city park, and pecan orchards associated with some of the houses.It includes two properties already separately-listed on the National Register: Hardy Bryan House (or Carter House), 312 North Broad Street, a Greek Revival house built by a carpenter/builder which is believed to be one of the earliest surviving houses in Thomasville; Lapham-Patterson House (1885), 626 North Dawson Street, a National Historic Landmark.Also notable in the district are: several rare examples of single pen houses on Broad Street and Lutten Lane Hardeway House (1856), 526 North Dawson Street) designed by builder/architect John Wind 312 North Dawson Street (1905), a "concrete stone" structure built as the administration building for Young's Female Academy.

The Stevens Street Historic District is a 175 acres (71 ha) historic district in Thomasville, Georgia. It is located one block northwest of Thomas County Courthouse. It was listed on the National Register of Historic Places in 2001. It was noted to be "an intact African-American neighborhood that developed in Thomasville, Thomas County following the end of the Civil War." It then included 341 contributing buildings and three contributing structures, as well as 83 non-contributing structures.Especially significant buildings include the Clay Street YMCA and the Recreation Center at 404 West Calhoun Street.

The Big Oak is a large live oak (Quercus virginiana) located in Thomasville, Georgia, in the United States at the corner of Crawford Street and Monroe Street. The Big Oak is one of many historic landmarks located in Thomasville. The Big Oak was one of the earliest trees registered with the Live Oak Society. Registered by P.C. Andrews in 1936, the Big Oak was the forty-ninth live oak registered. At the time of registration, the Big Oak's girth was 21 feet 6 inches.

The Church of the Good Shepherd, on Oak Street in Thomasville, Georgia, dates from 1908. It was listed on the National Register of Historic Places in 1987.The listing included three contributing buildings: the church (1894) and a parish hall that form a U-shaped complex, plus a vicarage (1908). The parish hall was built in 1896 and modified in 1907-1912 and in 1923.

The Dr. David Brandon House, also known as Hayes House, in Thomasville, Georgia, was built as a one-story brick house in 1851. A second floor with mansard roof was added in the 1870s. It was listed on the National Register of Historic Places in 1970.The house was built for Thomas Jones of Greenwood Plantation to serve as a wedding gift for his daughter Harriet and her husband, Dr. David S.Brandon. The house was sold to Mrs. John H. Hayes in 1862 and remained in the Hayes family in 1970.

The Hardy Bryan House, also known as Cater House, in Thomasville, Georgia, was built in c.1833. It is a well-preserved example of an antebellum plantation house. It was listed on the National Register of Historic Places in 1970. It is also a contributing building in the National Register-listed Dawson Street Residential Historic District. It is a two-and-a-half-story Plantation Style house with a two-story portico supported by four square columns. As of 1970, all of its windows were 16 over 16, many with their original glass.

Thomasville Commercial Historic District is a historic district that was listed on the National Register of Historic Places in 1984 and was both increased and decreased in 2004. The modified district, about 60 acres (24 ha) in size, then included 123 contributing buildings, three contributing structures, and a contributing object, as well as 65 non-contributing buildings.The district consists primarily of one- and two-story commercial buildings built between 1880 and the 1940s.It has a number of buildings dating back to the 1880s. For the historic district the Thomasville Main Street Program helped raise over $44 million for the district.The district includes: Thomas County Courthouse, 225 North Broad Street, separately NRHP-listed Thomasville Depot, separately NRHP-listed (three contributing buildings; within the 2004 increase) B'nai Israel Synagogue, separately NRHP-listed (within the 2004 increase) Hollybrook Building - Brokerage Exchange built in 1882 Lapham-Patterson House Thomasville Cultural Center

The Thomas County Courthouse is an historic government building built in 1858 and located on North Broad Street in Thomasville, Georgia, the seat of Thomas County. It was designed by architect John Wind.It was added to the National Register of Historic Places on June 22, 1970. It is also a contributing building in the NRHP-listed Thomasville Commercial Historic District.

The Ephraim Ponder House in Thomasville, Georgia, also known as the Sholar House, was built c.1854-56 It was listed on the National Register of Historic Places in 1970.It was built by Epraim Ponder, and served part of old Young's Female College in Thomasville in 1869 and latterly as home of the president of the old College. At the time of NRHP listing it was owned by John Sholar and wife.Its south facade is Greek Revival in style and faces the former Female College property.

The East Side School in Thomasville, Georgia, United States was built in 1915 and was the first purpose-built public school building in Thomas County. It was listed on the National Register of Historic Places in 1977.It is a two-story-with-basement T-shaped brick red building. Its brick is laid in common bond and it has buff-colored brick trim at windows, entrances, and corner quoins. Terra cotta is also used in detailing; the roof is red vitrified clay tile. Its NRHP nomination asserts that "The most outstanding feature of the interior is the flooring. All of the floors are of rift pine, i.e., quarter sawn, long leaf yellow pine of virgin growth, cut in the Thomasville area."It was built to serve the first seven grades; other grades were covered by the high school, which was in an 1875 brick building which had served as South Georgia College of Agriculture and Mechanical Art.It served as a school until 1976.It was presumably for white students only when built; the date of desegregation, if that occurred before closure, is not noted.

The Dewey City Historic District is a 110 acres (45 ha) historic district in Thomasville, Georgia which was listed on the National Register of Historic Places in 2008. It is an intact historically African-American neighborhood.It then included 110 contributing buildings, a structure, and a contributing site. It also included 100 non-contributing buildings and 35 non-contributing sites, and a non-contributing object.