Dr. J.O. and Catherine Ball House

The Henry Ambler House is a historic house located at 405 Broadway in Mount Pleasant, Iowa.

The Brazelton House is a historic house located at 401 North Main Street in Mount Pleasant, Iowa.

The Harlan House Hotel is a historic building located in Mount Pleasant, Iowa, United States. It is associated with James Harlan, the first Republican to represent Iowa in the United States Senate (1855-1865, 1867–1872). He was also Secretary of the Interior (1865-1867). His daughter Mary was the wife of Robert Todd Lincoln, President Abraham Lincoln's only surviving son. Harlan built the oldest part of this building as his house in 1857. After his career as a Senator, he could no longer afford the house and bought another house in Mount Pleasant. Harlan built the first addition onto his old house and converted it into a hotel so he could support himself. He added onto the hotel two more times, c. 1880 and 1892. The first two additions are on the alley side of the building, and the third addition faces Jefferson Street. The middle section of the building with the bracketed cornice and mansard roof is the original house. Harlan moved into the hotel in the early 1890s and died here in 1899. A few minor alterations were made to the building in the 20th century. It was listed on the National Register of Historic Places in 1987.

Iowa Wesleyan University is a private college in Mount Pleasant, Iowa. It is Iowa's first co-educational institution of higher learning and the oldest of its type west of the Mississippi River. The institution is affiliated with the United Methodist Church.it was founded as the Mount Pleasant Literary Institute in 1842, and was known as Mount Pleasant Collegiate Institute from 1843 to 1855, Iowa Wesleyan University from 1855 to 1912, and Iowa Wesleyan College from 1912 to 2015. The name reverted to Iowa Wesleyan University in 2015. Two campus buildings Old Main and the Harlan-Lincoln House are listed on the National Register of Historic Places. The latter, the former summer home of Robert Todd Lincoln, is now a museum featuring various artifacts from the Harlan and Lincoln families.

The former Second Baptist Church is a historic building located in Mount Pleasant, Iowa, United States. The First Colored Baptist Church of Mt. Pleasant, later Second Baptist Church, was founded in the summer of 1863 by members of First Baptist Church for the education and worship of the community's African American population. The congregation is also referred to as the "African Baptist Church". It is possible that this building was the original Methodist Episcopal church building constructed in 1843. It is believed that it was moved here in 1856 or 1857 for a newly established congregation of the Methodist Protestant Church. Either that or the main part of this small frame church was built here at that time. Regardless, the Methodist Protestant congregation did not succeed and the property was sold to First Baptist Church in January 1864 for use by the "Colored Baptist Church."Because the local school district integrated their schools in 1867, this building was no longer used for a school. They had a basement built under the church for social events in 1914. It is less certain when the entry vestibule was built onto the front of the building. It could have been added in 1914 when the basement was built, but it seems to have been in place by 1930. Second Baptist Church continued to worship here until 2009 when they moved to a different building. They donated this building to the Mount Pleasant Historic Preservation Commission in 2013. It was listed on the National Register of Historic Places in 2014.

The Former Mount Pleasant Public Library is a historic building located in Mount Pleasant, Iowa, United States. The library here was established in 1875. The community applied to Andrew Carnegie for a grant to build a new building, which was accepted on January 13, 1903. They were initially granted $10,000 and then were given a further $2,500. The Chicago architectural firm Patton & Miller designed the Romanesque Revival structure. They adapted Henry Hobson Richardson's Thomas Crane Public Library (1882) for this building. Unlike the Crane Library, this building is primarily brick with rough stone used for a short tower on the main facade and for the trim. It also features an asymmetrical grouping of intersecting gables. The building opened on Wednesday, February 22, 1905. An addition was built onto the rear of the building in 1926. It was designed by the Des Moines architectural firm of Dougher, Rich & Woodburn. The building was listed on the National Register of Historic Places in 1983. The library has subsequently moved to another facility and this building now houses a branch of Southeastern Community College.

Old Main is an historic building located on the Iowa Wesleyan University campus in Mount Pleasant, Iowa, United States. Built in 1854, when James Harlan was the college's president, it is the second building constructed on the campus after Pioneer Hall. It is believed that Old Main was the first genuine collegiate building built in Iowa. The bricks for the building were manufactured locally by Benjamin Franklin Pearson of Keosauqua, Iowa, who also was responsible for some of the building's construction. The three-story building has modified classical features. It was designed to have classrooms on the first two floors and the library, natural history museum and chapel on the third floor. The building is capped with a hip roof with bracketed eaves, and a wooden cupola with a low dome painted gold. The International P.E.O. Sisterhood was founded in the building. It was listed on the National Register of Historic Places in 1973.

The Masters Building is a historic building located in Mount Pleasant, Iowa, United States. Completed in 1937, this two story, brick structure is an adaptation of the commercial Art Deco and Art Moderne styles. The decorative elements are found in the brick patterning and cast concrete panels on the facade. There are three other buildings on this same block that were built about the same time and use the same decorative techniques, with the Masters Building being the best example. This area was an expansion of the central business district after the construction of city hall across the street in 1936. A plumbing business, for which this building was constructed, was located on the first floor. There are three apartments on the second floor. The building was listed on the National Register of Historic Places in 1991.

The Masonic Temple Theater (subsequently the Temple Twin Theaters, and in 2013 the Main Street Cinemas) is a historic building located in Mount Pleasant, Iowa, United States. Built in 1923, it combined both commercial and fraternal functions in one building. The theater company paid for the construction of the lower level, and the Masons paid for the upper level. The Masons continued to occupy the space until 1989 when they moved to another facility. The building was designed in the Neoclassical style by Owen, Payson & Carswell, and K.A. Bergdahl was the contractor who built it. Neoclassical features include the balustrade, the medallion with the Masonic insignia, volutes above the windows, the parapet roof, and the ornamental frieze and cornice. The building was listed on the National Register of Historic Places in 1991.

The McCandless Building is a historic building located in Mount Pleasant, Iowa, United States. This three story brick Italianate structure was built in 1862 by local builder William McCandless. With the arrival of the railroad in 1856, Mount Pleasant was in need of new commercial buildings to house businesses and services that were opening in the expanding town. They were built on the north and east side of the town square. The Italianate was a prominent style used in the city at this time having been used by about a dozen buildings. This buildings features three round arch windows on the second and third floors with brick patterned hood molds. The storefront has been altered slightly, and the heavy wooden cornice that graced the top of the main facade was removed some time ago. The building was listed on the National Register of Historic Places in 1991.

First National Bank is a historic building located in Mount Pleasant, Iowa, United States. The bank was first located on this corner in the 1860s. Its first building was a small, brick Italianate structure. This building replaced it in 1923. It is a two-story stone structure designed by Chicago architect Paul V. Hyland in the Neoclassical style. It is unique in Mount Pleasant in that it is the only stone building facing the square, and it reflects more of a public building instead of a commercial building. It is similar in style to the Henry County Courthouse, which is diagonally across the square. The exterior of the primary and secondary facades is composed of ashlar limestone and features paired pilasters on the corners of the primary facade, and a single column in the Corinthian order that flank the main entrance. It is capped with a simple classical cornice and parapet roof. The alley side of the building is composed of red brick. The building was listed on the National Register of Historic Places in 1991.

National State Bank is a historic building located in Mount Pleasant, Iowa, United States. Because this two story, brick Italianate structure was built specifically as a bank, it features a chamfered corner, which was commonly used to designate a bank in the last quarter of the 19th century. However, it combines other features typical of an Italianate commercial building in an unusual way. The secondary facade has segmental arched windows that are regularly spaced, while the primary facade has the windows in a sophisticated arrangement that one would expect of an architect-designed building. (The potential architect of this building, or even its builder, are unknown.) The metal cornice has widely spaced brackets on the primary facade and more typically spaced on the secondary facade. It also lacks an identification pediment on the corner, which is typical of the style. The building was listed on the National Register of Historic Places in 1991.