Carnegie-Stout Public Library

The Charles T. Hancock House, also known as the Hancock-Gross House, is a historic building located in Dubuque, Iowa, United States. Hancock owned a large wholesale grocery firm. He hired local architect Frank D. Hyde to design this three-story frame Queen Anne. Completed in 1890, the house is situated on the brow of a 64-foot (20 m) bluff. It has views of the city below, as well as the hills of Wisconsin and Illinois across the Mississippi River. While restrained when compared with other houses in this style, it does feature an irregular plan, a wraparound porch, multiple roof lines, narrow bargeboards in the gables, and a corner tower with a conical roof. The house was individually listed on the National Register of Historic Places in 1986, and it was included as a contributing property in the West Eleventh Street Historic District in 2004.

St. Luke's United Methodist Church, also known as St. Luke's Methodist and as St. Luke's United Methodist, is a historic Richardsonian Romanesque-style church located at 1199 Main Street in Dubuque, Iowa. It was individually listed on the National Register of Historic Places in 1998, and as a contributing property in the Upper Main Street Historic District in 2005. It is part of the Iowa Conference of the United Methodist Church. The church has more Tiffany windows than any other church in the state.According to its NRHP nomination, the building is significant for its history in religion in Dubuque, for its Richardsonian Romanesque (unique in Dubuque), and for its Tiffany glass.: 15 

The Interstate Power Company Building, also known as the Masonic Hall and the Dubuque Electric Company, is a historic building located in Dubuque, Iowa, United States. While a single facility, this is actually two buildings: an 1894 three-story Queen Anne, and a 1956 three-story (later four-story) Modern Movement free-standing addition. The Dubuque Electric Company moved into the older building in 1924, and the following year it was reorganized as Interstate Power Company. This became the headquarters of a regional electrical utility that, at one time, served parts of eight states and a Canadian province. The Great Depression and antitrust court rulings altered the company's fortunes. The 1956 addition was designed to hold the companies large computers in an air-conditioned environment, in addition to office space. Other additions to the building were made in 1962, 1981 and 1989. The facility remained Interstate's corporate headquarters until Alliant Energy bought and absorbed the company in 1996. Alliant continued to use the building for a period of time afterward. It was included as a contributing property in the Upper Main Street Historic District in 2005, and it was individually listed on the National Register of Historic Places in 2008.

Upper Main Street Historic District is a nationally recognized historic district located in Dubuque, Iowa, United States. It was listed on the National Register of Historic Places in 2005. At the time of its nomination it consisted of 24 resources, which included 18 contributing buildings, and six non-contributing buildings. In 2011 the boundaries of the district were expanded to include four additional buildings on the west side of the 900 block of Main Street. The district is the northern end of the city's most important commercial street. It is situated on a level terrace above the downtown area, located to the east. The buildings located on the east side of Main Street have exposed foundations along the alley because the grade descends in that direction. For the most part the district is made up of commercial buildings, although there is one house, four rowhouses, and a church. All of the buildings are masonry construction, and they are between one and four stories tall. The bell tower of St. Luke's United Methodist Church (1896) is equivalent to an eight-story building. St. Luke's Church and the Interstate Power Company Building (1894, 1956) are individually listed on the National Register.

Roshek Brothers Department Store was a large retail store in downtown Dubuque, Iowa. The company was founded by J.J.and F.H. Roshek. In its prime, Roshek's was the primary shopping destination in Dubuque and was the largest department store in the state of Iowa. The building has been listed on the National Register of Historic Places.

The Andrew–Ryan House is a historic house located in Dubuque, Iowa, United States. This is considered the best example of the Second Empire style in the city, and one of finest in the state of Iowa. The two-story brick structure was designed by Dubuque architect Fridolin J. Herr Sr. It was originally built 13 feet (4.0 m) to the north, but was moved to its present location between 1885 and 1890. The porches on the south side may have been added at that time. The house is from the high Second Empire style and features a mansard roof, arched windows, dominant chimneys, a prominent belvedere, and classical moldings on the pilasters, belt courses, and stone work. The house was individually listed on the National Register of Historic Places in 1985. It was included as a contributing property in the Jackson Park Historic District in 1986.

The Town Clock is a large clock that stands in downtown Dubuque, Iowa. The clock has stood over the city for over 140 years. The present clock is the second "Town Clock"; the first collapsed in the 1870s, killing three people. The building on which it originally stood is listed on the National Register of Historic Places, but the clock tower itself is not.

Dubuque YMCA Building, also known as the Iowa Inn, is a historic building located in Dubuque, Iowa, United States. Several area churches partnered to form the local YMCA in 1857. It was one of the first chapters formed west of the Mississippi River. Its activities ceased during the American Civil War, and it was reformed in 1866. They rented rooms on Main Street for their activities. Its first modest gymnasium was outfitted in 1884, and it was improved in 1992 when YMCA took over the facilities over the former Dubuque Athletic Club. The local YMCA completed the first section of this facility two years later, with the second section completed in 1916. Often the local YMCA chapters copied or adapted one another's building designs, which gave their facilities an institutional character in form and style. The Romanesque Revival style was popular in Iowa in the 19th century, which is reflected in the 1894 section. In the early 20th century they generally employed the Neoclassical and Commercial styles, and the 1916 wing reflects the Commercial style. YMCA remained here until 1969, when they opened a new joint facility with the YWCA on Dodge Street. This building became the Iowa Inn, which rented rooms to low-income people. MetroPlains Development of St. Paul, Minnesota bought the building in 2000 and renovated it into an apartment building for senior citizens known as the Henry Stout Apartments. It was named for an early supporter of YMCA in Dubuque.The building was listed on the National Register of Historic Places in 2002.

The Dubuque Museum of Art is an art museum in Dubuque, Iowa. The museum is known for its collection of works by Grant Wood. The collections include more than 2,500 works of art housed in the former Statesman Bank building in downtown Dubuque. The museum was founded in 1987, although it evolved out of the Dubuque Art Association which had been operating sporadically since 1874.

Jackson Park Historic District is a nationally recognized historic district located in Dubuque, Iowa, United States. It was listed on the National Register of Historic Places in 1986. This is primarily a residential area, with some institutional and commercial buildings, located north of the central business district. The city originally developed just to the south of here. The Cathedral Historic District represents the oldest residential neighborhood in Dubuque, and began to house the working-class people closer to the docks. Once the Jackson Park area opened for development the city's wealthier residents built their homes here. Architectural styles rang from the vernacular, which are found mainly along the bluff, to the high style found mainly along Main and Locust Streets. Most of the houses were built from the mid to the late 19th century. The Andrew-Ryan House (1873) was individually listed on the National Register. Most of the institutional architecture are churches, which include St. John's Episcopal Church (1878) and St. Patrick's Catholic Church (1878). Central High School, no longer extant, was located across from Jackson Park, and it was also individually listed on the National Register before its demise. The Carnegie-Stout Public Library (1902) is located on the south side of the district.

The Security Building, also known as the Stampfer Building, is a historic structure in Dubuque, Iowa, United States. The cream-colored building is associated with the J. F. Stampfer Co. department store.

St. John's Episcopal Church is a parish of the Diocese of Iowa, located in Dubuque, Iowa, United States. The church was included as a contributing property in the Jackson Park Historic District that was listed on the National Register of Historic Places in 1986.