Rudolph Schaeffer School of Design

On June 14, 2017, 38-year old Jimmy Lam fatally shot three coworkers at a United Parcel Service (UPS) facility in the Potrero Hill neighborhood of San Francisco, California, United States. Lam then shot and killed himself as police arrived at the facility. Two others were wounded by gunfire, and three people were injured while escaping.

The California Culinary Academy (CCA) was a for-profit school, and an affiliate of Le Cordon Bleu located in San Francisco, California. Danielle Carlisle established the school in 1977 to train chefs using the European education model. The original location on the corner of Fremont and Howard Street in the South of Market area of San Francisco, was located in the remodeled, top-floor, cafeteria in the Del Monte headquarters. The academy trained more than 15,000 people for restaurant careers through its 30-week baking and pastry chef program and 16-month culinary arts degree program. It was purchased by Career Education Corporation in 1999.

The San Francisco Center for the Book (SFCB) is a non-profit organization founded in 1996 by Mary Austin and Kathleen Burch in San Francisco, California in the United States. The first center of its kind on the West Coast, SFCB was modeled after two similar organizations, The Center for Book Arts in New York City and the Minnesota Center for Book Arts in Minneapolis. In their mission statement, SFCB is declared as "a center of inspiration for the book arts world, featuring the art & craft of letterpress printing, bookbinding, and artists' book making." Currently, SFCB offers over 300 workshops and 44 free events a year. In addition to workshops and events, they have a thriving exhibition program, Small Plates program, and collaborate with many local nonprofits, museums, and libraries. They also host special visits and hands-on demonstrations for students of all ages, teachers, librarians, corporate team building, collectors, visiting printers, artists, writers, and designers.

Seals Stadium was a minor league baseball stadium in San Francisco, that later became the first home of the major league San Francisco Giants. Opened in the Mission District in 1931, Seals Stadium was the longtime home of the San Francisco Seals (1931–57) of the Pacific Coast League. The Pacific Coast League Mission Reds (1931–37) shared the ballpark with the Seals for the first seven years before moving to Los Angeles. In 1958, Seals Stadium became a temporary home for the San Francisco Giants for their first two seasons in San Francisco while Candlestick Park was under construction. Less than three decades old, Seals Stadium was demolished in late 1959.

Takahashi Trading Company is a former Japanese-import home goods retail and wholesale business in the United States, and is the name of a 1912 warehouse building that once housed the business headquarters in the Potrero Hill neighborhood in San Francisco, California, U.S.. The business was active from 1945 until 2019, and had various retail locations nationwide. It was founded by the Japanese–American couple, Henri Takahashi and Tomoye "Tami" Takahashi.Since 2022, the warehouse building has been listed by the city as a San Francisco Designated Landmark.

Osito is a restaurant in San Francisco, California. Established in late 2021, the restaurant serves American cuisine and has received a Michelin star.

Vermont Street is a north–south street in the Potrero Hill district of San Francisco, one of a series of streets in the Potrero Hill district named after American battleships. It begins at Division Street near the South of Market area and runs south, paralleling the U.S. 101 freeway. At 22nd Street Vermont Street jumps to the other side of the freeway via a pedestrian bridge. That piece ends at 25th Street; Vermont resumes at 26th Street back on the east side of the freeway and continues to its south end at Cesar Chavez Street.

Anchor Brewing Company is an American alcoholic beverage producer, operating a brewery on Potrero Hill in San Francisco, California. The brewery was founded in 1896 and was purchased by Frederick Louis Maytag III in 1965, saving it from closure. It moved to its current location in 1979. It is one of the last remaining breweries to produce California common beer, also known as Steam Beer, a trademark owned by the company.In 2010, the company was purchased by The Griffin Group, an investment and consulting company focused on beverage alcohol brands. The brewery became one facet of the Anchor Brewers & Distillers, LLC portfolio.On 3 August 2017, it was acquired by Japanese brewing giant Sapporo Breweries for US$85 million.

San Ho Won is a Korean restaurant in San Francisco's Mission District, in the U.S. state of California.The restaurant has received a Michelin star.

Established in 1998, the Wattis Institute for Contemporary Arts is a contemporary art center in San Francisco, California, US, and part of the California College of the Arts. It holds exhibitions, lectures, and symposia, releases publications, and runs a residency program, Wattis.

Rescue Row is a city block in the Mission District of San Francisco, California known for containing several of San Francisco’s animal rescue & pet adoption organizations.

The Potrero Hill Neighborhood House (also known as "The NABE") is a multipurpose community center and historic building built in 1922 at 953 DeHaro Street in the Potrero Hill neighborhood of San Francisco, California, U.S.. The Potrero Hill Neighborhood House has been listed as a San Francisco Designated Landmark since July 9, 1977.