Martin Luther King Boulevard/Mack Avenue station

The University of Michigan Detroit Center (UMDC, U-M Detroit Center or Detroit Center) is a community outreach center, meeting/events facility, and academic home base for University of Michigan units, located in Midtown Detroit. The facility serves as a home base to more than 50 university staff and faculty members from the campuses of the University of Michigan and University of Michigan-Dearborn. Providing a visible symbol of the nearly 200-year relationship between the City of Detroit and the University of Michigan, the U-M Detroit Center serves as a gateway for University and urban communities to take advantage of each other’s learning, research and cultural activities. The mission of the University of Michigan Detroit Center is to mutually enrich University and Detroit communities through service, education, research and the exchange of culture.

The Milner Arms Apartments, originally known as the Hotel Stevenson, is a high rise building located at 40 Davenport Street in Midtown Detroit, Michigan; it was listed on the National Register of Historic Places in 1997. It is adjacent to, but not part of, the Cass-Davenport Historic District.

Orchestra Hall is an elaborate concert hall in the United States, located at 3711 Woodward Avenue in Midtown Detroit, Michigan. The hall is renowned for its superior acoustic properties and serves as the home of the internationally known Detroit Symphony Orchestra (DSO), the fourth oldest orchestra in the United States. With the creation of an adjoining auditorium for jazz and chamber music in 2003, Orchestra Hall became part of the Max M. and Marjorie S. Fisher Music Center. It was listed on the National Register of Historic Places in 1971.

The Professional Plaza Tower, also known as the 'Hammer and Nail' building due to its two iconic illuminated signs (now removed), is a high-rise building located at 3800 Woodward Avenue in Midtown Detroit, Michigan. It was listed on the National Register of Historic Places in 2016.

The Chapel of St. Theresa–the Little Flower was a church located at 58 Parsons Street in Midtown Detroit, Michigan. It was later known as St. Patrick Church. The building was listed on the National Register of Historic Places in 1997, and demolished in September 2023.

The Bonstelle Theatre is a theater and former synagogue owned by Wayne State University, located at 3424 Woodward Avenue (the southeast corner of Woodward and Eliot) in the Midtown Woodward Historic District of Detroit, Michigan. It was built in 1902 as the Temple Beth-El, and was listed on the National Register of Historic Places in 1982. As of 2023, the Bonstelle is planned to be renovated and integrated into a newly-constructed hotel.

Sts. Peter and Paul Academy is a Catholic school building located at 64 Parsons Street in Midtown Detroit, Michigan. It currently serves as the St. Patrick Senior Center. It was listed on the National Register of Historic Places in 1997.

The Albert Kahn House is in Midtown Detroit, Michigan, within the Brush Park district. It is currently the headquarters of the Detroit Urban League. The house was designated a Michigan State Historic Site in 1971 and listed on the National Register of Historic Places in 1972.

The Robert M. and Matilda (Kitch) Grindley House was a private residence located at 123 Parsons Street in Detroit, Michigan. It was listed on the National Register of Historic Places in 1997, but was subsequently demolished.

The Midtown Woodward Historic District is a historic district located along Woodward Avenue in Detroit, Michigan. Structures in the district are located between 2951 and 3424 Woodward Avenue, and include structures on the corner of Charlotte Street (14 Charlotte Street) and Peterboro Street (10 and 25 Peterboro Street). The district was admitted to the National Register of Historic Places in 2008.

The Eugene Applebaum College of Pharmacy and Health Sciences was founded in 1924. Previously known as the College of Pharmacy and Allied Health Professions, the name changed to the Eugene Applebaum College of Pharmacy and Health Sciences in the year 2000. It is currently located in Midtown Detroit, Michigan and is one of Wayne State University's professional schools. There are currently 12 programs being offered at the school. The college is divided into four academic departments: Applied Health Sciences, Health Care Sciences, Pharmacy Practice, and Pharmaceutical Sciences.

McLaughlin Hall (also known as Emily A. McLaughlin Hall, or McLaughlin Hall of the Farrand Training School, Detroit) is an American World War I memorial building in Detroit, Michigan, located at 3740 John R Street. Completed in 1922, it originally functioned as a nurses' home and as a nurses' training school, both associated with Harper Hospital. By 2015, the building was repurposed for hospital administrative offices.McLaughlin Hall was said to be the most beautiful and complete nurses' home in the U.S. It was donated to Harper Hospital by James Couzens, mayor of Detroit. The home is a memorial to the nurses of the Farrand Training School, who served during World War I and is the first memorial in the U.S. dedicated to nurses of the war. In addition to living rooms, principal's quarters, nurses' rooms and the infirmary, there is a large demonstration and lecture room, a smaller classroom and a laboratory. All these rooms are equipped for teaching and demonstration.