Eugene Applebaum College of Pharmacy and Health Sciences

DMC Rehabilitation Institute of Michigan (RIM) is one of the eight hospitals affiliated with the Detroit Medical Center. RIM is one of the largest, academic, rehabilitation hospitals in the United States specializing in rehabilitation medicine and research. RIM offers clinical treatment in spinal cord injury, brain injury, stroke, complex trauma and orthopedics and catastrophic injury care. The institute is home to the Center for Spinal Cord Injury Recovery, a facility designed to implement and study innovative treatments in spinal cord injury recovery. RIM also houses the Southeastern Michigan Traumatic Brain Injury System (SEMTBIS) which conducts groundbreaking research in the field of rehabilitation medicine, sharing the resulting innovations with brain injury providers worldwide. Clinical researchers study issues such as medication effects, course of recovery, psychological factors and treatment outcomes. RIM also operates over 30 outpatient therapy clinics throughout southeast Michigan, specializing in physical therapy, sports medicine and orthopedics.

The Albert Kahn House is in Midtown Detroit, Michigan, within the Brush Park district. It is currently the headquarters of the Detroit Urban League. The house was designated a Michigan State Historic Site in 1971 and listed on the National Register of Historic Places in 1972.

McLaughlin Hall (also known as Emily A. McLaughlin Hall, or McLaughlin Hall of the Farrand Training School, Detroit) is an American World War I memorial building in Detroit, Michigan, located at 3740 John R Street. Completed in 1922, it originally functioned as a nurses' home and as a nurses' training school, both associated with Harper Hospital. By 2015, the building was repurposed for hospital administrative offices.McLaughlin Hall was said to be the most beautiful and complete nurses' home in the U.S. It was donated to Harper Hospital by James Couzens, mayor of Detroit. The home is a memorial to the nurses of the Farrand Training School, who served during World War I and is the first memorial in the U.S. dedicated to nurses of the war. In addition to living rooms, principal's quarters, nurses' rooms and the infirmary, there is a large demonstration and lecture room, a smaller classroom and a laboratory. All these rooms are equipped for teaching and demonstration.

Recreation Park was a ballpark located in Detroit. It is best known as the home of the Detroit Wolverines of the National League from 1881 to 1888. Recreation Park was built in 1879. Its developers intended it to be a multi-use facility. There was a half-mile dirt track running along the outside of the property to be used for horse racing, bicycling and foot races. The owners also envisioned use for baseball, cricket, archery, croquet, as well as ice skating in the winter. Detroit fielded a minor league team that summer. Two years later the Wolverines major league team made its debut. The first major league baseball game in Detroit was played here on May 2, 1881.As the 1880s progressed, the team improved and won the National League pennant in 1887, as well as the World Series, defeating the St. Louis Browns of the American Association. By the end of the next season, the club was losing money in spite of its successes, and dropped out of the league. Minor league ball resumed in 1889 and was played for two seasons (plus one game in 1891) before the club folded altogether. Recreation Park continued to be used for various other activities, but by 1894 it was pretty much abandoned, and the structures were demolished. The Park was on a rectangular site north of the downtown area, less than a mile from the location of the future Comerica Park. The field was laid out so that the foul lines hit the fences at a 135° angle, similar to the Polo Grounds and various other parks of that era. It was bounded on the south by Brady Street, on the east by Beaubien Street, and on the west by Harper Hospital, beyond which lay John R Street. Brush Street made a T-intersection against Brady at the southwest corner of the lot where the main entrance gate was. For that reason, the location is often given as simply "Brady and Brush Streets." Across the centerfield fence, to the north, was the other half of the Recreation Park complex, a cricket field. Contemporary maps depict an oval track around the cricket field, as with the baseball field, and a larger oval enclosing the entire property. The northern boundary of the property, according to initial contemporary newspaper accounts, was Fremont Street (now Canfield Street). Later accounts placed the northern border at Willis Street, a block south of Fremont / Canfield. Although the ballpark is long gone, Harper Hospital still exists, housed in new buildings, and overlooking the site where the major league Wolverines once played. An historical marker commemorating Recreation Park is placed in what was once left field, among the buildings of the present Detroit Medical Center.

Alpha House is a fraternity house located at 293 Eliot Street in Detroit, Michigan. It is significant as the longtime headquarters of the Gamma Lambda Chapter of Alpha Phi Alpha fraternity. The house was listed on the National Register of Historic Places on August 26, 2021.

The William Livingstone House, commonly called Slumpy, was a house constructed in 1894 and located in the Brush Park district of Detroit, Michigan.

Children's Hospital of Michigan (CHM) is a for-profit, pediatric acute care hospital located in Detroit, Michigan. The hospital has 227 beds and is affiliated with both the Wayne State University School of Medicine and the Michigan State University Medical School. The hospital provides comprehensive pediatric specialties and subspecialties to pediatric patients aged 0–21 throughout eastern Michigan and the Detroit area and is a part of the Detroit Medical Center. The hospital features the only freestanding pediatric Level 1 Pediatric Trauma Center in the Detroit region, 1 of 3 in the state. It is an international provider of pediatric neurology, neurosurgery, cardiology, oncology and diagnostic services including Positron Emission Tomography and MRI.

Martin Luther King Boulevard/Mack Avenue is a streetcar station on the QLINE in Midtown Detroit, Michigan. The station opened for service on May 12, 2017. The station services the northern Brush Park and middle Cass Corridor neighborhoods. The northbound platform is signed as Mack Avenue, and the southbound as MLK Boulevard, as the street changes names at Woodward.

Hutzel Women's Hospital is one of the eight institutions that compose the Detroit Medical Center. The hospital itself is connected to Harper University Hospital, on the midtown Detroit campus of the Medical Center. It is the only hospital in Southeast Michigan dedicated to women's care. As Michigan's first and only hospital for women, Hutzel Women's Hospital has been The Destination for Women's Care since 1868.

The Bonstelle Theatre is a theater and former synagogue owned by Wayne State University, located at 3424 Woodward Avenue (the southeast corner of Woodward and Eliot) in the Midtown Woodward Historic District of Detroit, Michigan. It was built in 1902 as the Temple Beth-El, and was listed on the National Register of Historic Places in 1982. As of 2023, the Bonstelle is planned to be renovated and integrated into a newly-constructed hotel.

The University of Michigan Detroit Center (UMDC, U-M Detroit Center or Detroit Center) is a community outreach center, meeting/events facility, and academic home base for University of Michigan units, located in Midtown Detroit. The facility serves as a home base to more than 50 university staff and faculty members from the campuses of the University of Michigan and University of Michigan-Dearborn. Providing a visible symbol of the nearly 200-year relationship between the City of Detroit and the University of Michigan, the U-M Detroit Center serves as a gateway for University and urban communities to take advantage of each other’s learning, research and cultural activities. The mission of the University of Michigan Detroit Center is to mutually enrich University and Detroit communities through service, education, research and the exchange of culture.

The Milaflores Massacre is the name given to the shooting of three gangsters in retaliation for two murders and a kidnapping in the winter of 1927 in Detroit, Michigan. The crime was suspected to have been perpetrated by the Purple Gang.