New England Adolescent Research Institute

The Flats is a neighborhood in Holyoke, Massachusetts located to the east of the city center, adjacent to the downtown. Although it lies at one of the lowest elevations in Holyoke, its name derives not from topography but from the brick tenement "flats" which characterized its architecture throughout much of its history. Historically the area has also been associated with the name Depot Hill, as it was the location of the city's first freight and passenger railway stations; passenger service was restored at Holyoke station in 2015, following a period of absence after 1967. A section of the neighborhood between Lyman and Appleton Street to north and south respectively, and between Race and Bowers Street to the east and west is also known as Depot Square. Today the area features the Holyoke Innovation District, Canal System, Hadley Falls Company Housing District, Marcella Kelly Elementary School, local Amtrak station and 275 acres (111 ha) of residential, commercial, and industrial zoning. The Flats faced mass depopulation following the issuance of city master plans in 1961 and 1968, which called for its conversion from mixed zoning to entirely industrial land use; from 1970 to 1980 this urban renewal initiative, combined with fires from substandard housing conditions and arson, reduced the number of housing units in the neighborhood by 41%. In recent years municipal and state authorities have sought to redevelop the neighborhood as a startup company incubator and cultural center through the creation of the Innovation District and Canalwalk. Proposals have also been put forth for redevelopment of the historic H. H. Richardson train station as well as the Hotel Jess/Perkins Block. While not on the National Register of Historic Places, the latter holds historical significance as it was constructed by Benjamin F. Perkins, a contemporary of Alexander Graham Bell, who had manufactured and demonstrated early telephone equipment personally for the inventor during his visits to Holyoke, and whose eponymous block was the first headquarters of the Springfield Telephone and Automatic Signal Company, a division of the Bell company, and Western Massachusetts' first telephone exchange, established in 1878. That same year the building became one of two sites for the world's first public-use toll line, which connected Springfield and Holyoke when it entered service on June 15, 1878.

The Hadley Falls Company Housing District is a residential historic district encompassing a compact tract of factory worker housing in Holyoke, Massachusetts. Built in 1847-48, it is one of the earliest and largest surviving examples of company-built worker housing in the state. It includes five rowhouses facing Center, Lyman, Grover, and Canal Streets. The district was listed on the National Register of Historic Places in 1972.

The Holyoke Canal System is a system of power canals in Holyoke, Massachusetts. It is split into three canals based on elevation and distance from the inlet at the Holyoke Dam- the First Level Canal, Second Level Canal, and Third Level Canal. Constructed over a period between 1847 and 1892, the Canal System, along with the Dam, is recognized as a Historic Mechanical Engineering Landmark by the American Society of Mechanical Engineers for its use in the development of the Venturi meter by Clemens Herschel, the first means of measuring large-scale flows, and the McCormick-Holyoke Turbine by John B. McCormick, which doubled the efficiency of turbines to more than 80% in its time.

The Vietnam Memorial Bridge (aka Holyoke Bridge, South Hadley Falls Bridge, and County Bridge) is a girder bridge that spans the Connecticut River between South Hadley and Holyoke, Massachusetts. It was built in 1990 to replace the original Holyoke-South Hadley bridge that was built in 1889 by New Jersey Steel and Iron Company and was designed by Edward S. Shaw.

Doing business as D. H. & A. B. Tower, brothers David Horatio Tower (March 7, 1832 – December 22, 1907) and Ashley Bemis Tower (June 26, 1847 – July 8, 1901) were internationally known American architects, civil and mechanical engineers based in Holyoke, Massachusetts, who designed mills and factories in the United States from Maine to California as well as abroad, including in Canada, Mexico, Germany, Brazil, the United Kingdom, India, China, Japan, and Australia. By the time of its dissolution, the firm was described by one contemporary account as "the largest firm of paper mill architects in the country at that time"; its files reportedly contained more than 8,000 architectural plans for sites, mill machinery, and waterpower improvements.In a treatise on his own work in mill engineering, Joseph Wallace, former partner to Ashley B. Tower, lauded their work posthumously saying "the history of paper mill engineering is largely the story of the work of the 'Towers of Holyoke,' followed by the younger generation of engineers trained in the Tower offices." Their most famous works include Kimberly Clark's earliest pulp plants in Kimberly, Wisconsin for which Ashley B. Tower furnished designs, and David H. Tower's designs for Crane Currency, of Dalton, Massachusetts, for the first facilities to produce currency paper for the United States Bureau of Engraving and Printing.

Holyoke station is an Amtrak intercity train station near the corner of Main and Dwight streets in Holyoke, Massachusetts, United States. The station opened on August 27, 2015, eight months after Amtrak's Vermonter service was re-routed to the Connecticut River Line through the Pioneer Valley. The first railroad station in Holyoke had opened in 1845, followed by the H.H. Richardson-designed Connecticut River Railroad Station in 1885. Though passenger service to Holyoke ended in 1966, the 1885 depot is still extant. The opening of the new station returned passenger rail service to Holyoke for the first time in 49 years, and to the Dwight and Main streets site for the first time in 130 years. A pilot program added two daily Amtrak Shuttle round trips in August 2019 under the Valley Flyer moniker.

The Holyoke Merry-Go-Round (PTC #80) is a historic carousel in Holyoke, Massachusetts. Previously a ride in the city's now-defunct Mountain Park, it was purchased and restored by a volunteer fundraising campaign following the park's closure in 1987, and opened at a new building based its original pavilion in Holyoke Heritage State Park in 1993. The carousel is one of about 30 remaining carousels built by Philadelphia Toboggan Coasters.

The Holyoke Opera House was a theatre operating in Holyoke, Massachusetts during the 19th and early 20th centuries. Built in 1877, and christened on March 25, 1878, the theater was built by then-mayor William Whiting who privately-funded its construction along with the adjoining "Windsor House" hotel. Designed by architect Clarence Sumner Luce, its interior was decorated by painter and designer Frank Hill Smith, who is best known today for the frescoes in the House of Representatives' chamber in the Massachusetts State House, and whose commission for the venue's main hall paintings has been described by the American Art Directory and historian John Tauranac as one of his definitive works.Its opening show was a performance of Louie XI starring John W. Albaugh. In its first decades it was among the largest theaters in the country, and gained a number of notable acts. In later decades it became a vaudeville and burlesque establishment. Following the introduction of moving pictures, the opera house saw a steady decline and by the time the venue was purchased by E. M. Loew in 1945, The Film Daily described it as a "once-famous theater". On October 29, 1967, the venue was destroyed in a multiple-alarm fire, with such damage that officials could not determine its cause.

The Holyoke Dam, also referred to as the Hadley Falls Dam, or Hadley Falls Station is a granite dam built in tandem with the Holyoke Canal System at Hadley Falls on the Connecticut River, between Holyoke and South Hadley, Massachusetts. The water differential crated by the dam produced mechanical hydropower for industrial uses in Holyoke, and later hydroelectric power. The current dam is the third structure to be built across the Great Falls at South Hadley. The dam, along with the Canal System and its Testing Flume, is recognized by the American Society of Mechanical Engineers as a Historic Mechanical Engineering Landmark for its use by Clemens Herschel in the development of the Venturi meter, the first means of measuring large-scale flows, and the McCormick-Holyoke Turbine by John B. McCormick, also known as the Hercules Turbine, which doubled the efficiency of turbines to more than 80% in its time.

The International Volleyball Hall of Fame (IVHF) was founded to honor extraordinary players, coaches, officials, and leaders who have made significant contributions to the game of volleyball. The Hall of Fame is located in Holyoke, Massachusetts, where volleyball was invented in 1895 by William G. Morgan at the local YMCA.

The Willimansett Bridge is a steel truss bridge over the Connecticut River located between Chicopee, Massachusetts and Holyoke, Massachusetts. It carries Massachusetts state routes 116 and 141.

Holyoke Heritage State Park is history-oriented state park located in the city of Holyoke, Massachusetts. The park opened in 1986 on the site of the William Skinner Silk Mill which was lost to fire in 1980. The park is managed by the Massachusetts Department of Conservation and Recreation.