Church of St. Johns, Vilnius

Kardynalia Palace is a no-longer-existing palace in Vilnius, located at the corner of Pilies and St. John's Streets, right next to the university Church of St. Johns. The palace was constructed between the 16th and 17th centuries for the Radziwiłł family. One of its owners at the time was Cardinal and Bishop of Vilnius Jerzy Radziwiłł, from whom the palace derived its name. The palace remained in the possession of the Radziwiłłs for about 300 years, and in the 19th century, it became a government building. Damaged in 1944, it was not rebuilt after World War II, and in 1956, the palace's remnants were demolished to make way for residential buildings.

Vilnius University Library or VU Library (also VUL) is the oldest and one of the largest academic libraries of Lithuania. It was founded in 1570 by the Jesuits and as such is nine years older than Vilnius University. VU Library holds 5.4 million documents on shelves measuring 166 kilometres (103 mi) in length. The holdings, accessible to members of the university and wider public, include some of the oldest manuscripts, incunabula and engravings in Lithuania and Eastern Europe. At present the library has 36 thousand users. Vilnius University Library consists of the Central Library which is situated near the Presidential Palace, the Scholarly Communication and Information Centre in Saulėtekis and libraries of faculties and centres that are scattered all around the city.

The Museum of Antiquities (Lithuanian: Senienų muziejus, Polish: Muzeum Starożytności) in Vilnius (Vilna, Wilno) was a museum of archaeology and history established by Count Eustachy Tyszkiewicz in 1855 at the premises of the closed Vilnius University. It was the first public museum in the former Grand Duchy of Lithuania and is considered a predecessor of the National Museum of Lithuania even though only a handful of items from the Museum of Antiquities ended up at the National Museum. Together with the Archaeological Commission which functioned as a de facto learned society, the museum was the most prominent cultural and scientific institution in all of Lithuania and displayed many historical items that reminded of the old Grand Duchy and served romantic nationalism of Lithuanian nobles at the time when Lithuania was part of the Russian Empire. The museum collections rapidly grew to over 67,000 items in 1865 by absorbing large collections of minerals and zoological specimens from the closed Vilnius University, libraries of various closed Catholic churches and monasteries, and various donations from local nobles. The museum was nationalized and reorganized after the failed Uprising of 1863, removing almost all items related to the former Polish–Lithuanian Commonwealth to the Rumyantsev Museum in Moscow. The museum became a division of the newly established Vilnius Public Library. The reformed library and museum served to support the official Russification policies and displayed many items related to the Russian Empire and the Eastern Orthodox Church. After losing the last significant cultural center that supported the culture of the former Grand Duchy of Lithuania, Vilnius was becoming a Russian provincial city and losing its leading role in Polish–Lithuanian cultural life. The museum continued to operate until World War I when its most significant holdings were evacuated to the Rumyantsev Museum. The handful of items that remained in Vilnius and were not lost during the wars are held by various museums, including the National Museum of Lithuania, the Lithuanian Art Museum, and the Geology and Zoology Museums of Vilnius University.

European Humanities University (Belarusian: Еўрапейскі гуманітарны ўніверсітэт (ЕГУ), Lithuanian: Europos humanitarinis universitetas (EHU), Russian: Европейский гуманитарный университет (ЕГУ)) is a private, non-profit liberal arts university founded in Minsk, Belarus, in 1992. Following its forced closure by the Belarusian authorities in 2004, EHU relocated to Vilnius (Lithuania) and thus continues its operations as a private university. EHU offers high-residence and low-residence undergraduate, graduate and postgraduate degree programs in the field of humanities and social sciences. The university has been headquartered in Vilnius, Lithuania, since authorities expelled it from Belarus in 2004. The university intends to return to Minsk.From 1992 to 2004 EHU was a non-state establishment of undergraduate and post-graduate education in Belarus. In 2004, due to government opposition, EHU was forced to terminate its activities in Belarus. However, thanks to political, administrative, and financial support from the European Union, the Nordic Council of Ministers, the Governments of Lithuania, other European countries, and the United States, NGOs and foundations like MacArthur Foundation, Carnegie Corporation of New York, and others, EHU resumed its operation in Vilnius, Lithuania and opened bachelor's and master's degree programs for Belarusian students in autumn 2005. In March 2006 the Government of Lithuania granted EHU the official status of a Lithuanian university. After the mass protests of the Belarusian presidential election of 2010, many EHU students and teachers were imprisoned by the KDB. The university said it would work with students to help them in their education despite the circumstances.In academic year 2020/21 EHU serves around 680 mostly Belarusian students, offering undergraduate and graduate degree programs and promoting research in the humanities and social sciences. About two-thirds of EHU's students attend via online programs and reside in Belarus. About one-third attend courses on campus in Vilnius. Teaching languages – Belarusian, Russian, some courses are taught in English, German and French. EHU ranks second among private universities in Lithuania.

Vilnius University (Lithuanian: Vilniaus universitetas) is a public research university, which is the first and largest university in Lithuania, as well as one of the oldest and most prominent higher education institutions in Central and Eastern Europe. Today, it is Lithuania's leading research institution, ranked among the Top 29% Higher Education Institutions in the world.The university was founded in 1579 as the Jesuit Academy (College) of Vilnius by Stephen Báthory. It was the third oldest university (after the Cracow Academy and the Albertina) in the Polish–Lithuanian Commonwealth. Due to the failure of the November Uprising (1830–1831), the university was closed down and suspended its operation until 1919. In the aftermath of World War I, the university saw failed attempts to restart it by the local Poles, Lithuanians, and by invading Soviet forces. It finally resumed operations as Polish Stefan Batory University in August 1919. After the Soviet invasion of Poland in September 1939, the university was briefly administered by the Lithuanian authorities (from October 1939), and then after Soviet annexation of Lithuania (June 1940), punctuated by a period of German occupation after Operation Barbarossa, from 1941 to 1944, when it was administrated as the Vilnius State University. In 1945, the Polish community of students and scholars of Stefan Batory University was transferred to Nicolaus Copernicus University in Toruń. After Lithuania regained its independence in 1990, following the dissolution of the Soviet Union, it resumed its status as one of the prominent universities in Lithuania. The university has facilities in Kaunas and Šiauliai. It has 15 academic faculties that offer more than 200 study programs for over 24,000 students. Non-academic departments of the university include the Cultural Centre, Health and Sports Centre, Library, Museum, Botanical Gardens and other institutions. Since 2016, Vilnius University has been a member of a network of prestigious universities–the Coimbra Group–and since 2019, it has belonged to the European University Alliance (ARQU).The Vilnius University Foundation was established on 6 April 2016, becoming the first university endowment in Lithuania. Underground beneath the old university's building is the cenotaph of 11 Old Prussian tribes along with the small temple of four gods and four goddesses from Baltic mythology.

The House of the Signatories (Lithuanian: Signatarų namai, previously known as Sztral's House) is a Lithuanian historic landmark on Pilies Street, Vilnius, where on February 16, 1918, the Act of Independence of Lithuania was signed by twenty members of the Council of Lithuania.

Pac Palace is a building in the Old Town of Vilnius, Lithuania, on Šv. Jonų street, close to Vilnius University. Currently it houses the Polish embassy.

St. Paraskeva Church (Lithuanian: Vilniaus Šv. kankinės Paraskevės cerkvė; Russian: Пятницкая церковь) is the oldest Eastern Orthodox church in Lithuania, located in the capital Vilnius, belonging to the Russian Orthodox Diocese of Lithuania. The first Orthodox church of St. Paraskeva was constructed at the request of Grand Duke Algirdas's first wife, Maria Yaroslavna of Vitebsk, who was subsequently buried there in 1346. According to tradition, the church was built on the site of a temple to the pagan god, Ragutis. This church was completely destroyed by fire in 1557 and rebuilt three years later, but burned down again in 1611. Although ruined, it was given to the local Eastern Catholics. In 1655, it was given back to the Orthodox Church and renovated. During the Great Northern War, in 1705, with Vilnius invaded and pillaged by the Muscovite army, the church was visited by the Russian tsar Peter the Great, who prayed there for the military victory. During the same service, Abram Petrovich Gannibal was baptised, with the tsar serving as the godfather. Three years later, the victorious tsar decided to grant some of the conquered Swedish flags to St. Paraskeva's church. In 1748, the building was again destroyed by fire and rebuilt in 1795. However, it stood closed during the following forty years, slowly falling into decline. In 1864, on the orders of the Russian local government, it was rebuilt and enlarged in Neo-Byzantine style by Nikolay Chagin. The church was devastated during the World War II. Although it was renovated again, the Stalinist government didn't allow the Russian Orthodox Church to start holding its services there. At first, a Museum of Atheism was to be opened there, but in the end the church was turned into a gallery of Lithuanian folk art. The church was given back to the Orthodox Church only in 1990 and reconsecrated by Metropolitan Chrysostom the following year. Since then it has been an auxiliary church of the Cathedral of the Theotokos.

Vilnius University Astronomical Observatory is an astronomical observatory of Vilnius University. It was founded in 1753 by initiative of Thomas Zebrowski. The observatory is the fourth oldest observatory in the Europe. While the observatory is no longer able to make astronomical observations due to light pollution in Vilnius (observations are carried out at Molėtai Astronomical Observatory), it continues scientific research.

Literatų Street (literally: Literati Street; Lithuanian: Literatų gatvė) is one of streets in the Old Town of Vilnius, the capital of Lithuania. It is a short narrow street mostly known for public display of decorative and artistic plaques dedicated to writers who have lived and worked in Vilnius or otherwise have shared a connection with Vilnius and Lithuania. The artwork was first added in 2009 when Vilnius was designated as the European Capital of Culture and has grown to some 200 plaques.Its name originates from the many printing houses and bookstores which were located in the street or from the fact that prominent poet Adam Mickiewicz briefly lived there in 1823.

The Chodkiewicz Palace (or, in Lithuanian transliteration, Chodkevičiai Palace) is a building in Old Town of Vilnius on Didžioji St. Currently it is owned by the Lithuanian Art Museum.

Pilies Street (literally, "Castle Street"; Lithuanian: Pilies gatvė) is one of the main streets in the Old Town of Vilnius, the capital of Lithuania. It is a rather short street, running from Cathedral Square to the Town Hall Square.Pilies Street is a popular location for market traders to sell the wares of folk artists. It has a natural advantage over the Town Hall Square as the street is generally busy and less likely to be interrupted by the political or cultural events commonly held at the Town Hall. Souvenir shops offer amberware and amber jewelry as well as linen clothes. The street is also known for the Kaziukas Fair, when folk artists from all over Lithuania gather here to display and sell their latest merchandise. Festivals in Vilnius frequently take place on Pilies Street – most processions will make their way through here at some point. This is true whatever the festival – be it Christmas, Easter, the day of Restoration of Independence, or just a spontaneous celebration following a major win for the Lithuanian basketball team. The headquarters of Vilnius University are located between Pilies Street and University Street, (Lithuanian: Universiteto gatvė). The House of the Signatories where the Declaration of Independence was signed on February 16, 1918 is also located on this street.