St. Joseph's Chapel of the Manhattan State Hospital

Kirby Forensic Psychiatric Center is a maximum-security facility for the mentally ill on Wards Island in New York City, operated by the New York State Office of Mental Health as one of two psychiatric hospitals in the state that treat felony patients. The building, described as "fortresslike", is adjacent to the Manhattan Psychiatric Center. Of its more than 200 patients, 50 are deemed criminally insane; it houses pre-trial detainees unfit to stand trial as well as convicted defendants granted an insanity plea. Among its famous historical inmates was murderer and cannibal Daniel Rakowitz.

The Manhattan Psychiatric Center is a New York-state run psychiatric hospital on Wards Island in New York City. As of 2009, it was licensed for 509 beds, but holds only around 200 patients. The current building is 17 stories tall. The building strongly resembles the main building of the Creedmoor Psychiatric Center in Queens. It is adjacent to Kirby Forensic Psychiatric Center, a specialized facility for patients with criminal convictions.

The Wards Island Bridge, also known as the 103rd Street Footbridge, is a bridge crossing the Harlem River between Manhattan Island and Wards Island in the Manhattan borough of New York City that does not allow vehicular traffic. The vertical lift bridge has a total of twelve spans consisting of steel towers and girders. It carries only pedestrian and bicycle traffic. On the Manhattan side of the river, the bridge is located at East 103rd Street, between Exits 14 and 15 of the FDR Drive. The bridge is accessible from the East River Greenway and a pedestrian overpass across the FDR Drive to the East River Houses apartment complex in East Harlem. The bridge connects to the southwestern corner of Wards Island and provides access to the many playing fields and scenic waterfront of Randall's Island and Wards Island Parks. Wards Island Bridge is open to pedestrians and cyclists 24 hours a day, year-round. Prior to a 2010–2012 renovation, the bridge had only been available for use from April through October during the daytime.

On June 28, 1880, a boiler aboard the steamboat Seawanhaka exploded while the boat was in the East River near Wards Island, New York City, setting the boat on fire and resulting in the deaths of 24 to 35 people. A coroner's jury found that although the boiler had passed inspection the prior March and should have been in good working condition, the loss of life was exacerbated by the poor discipline of the boat crew following the explosion.

The Young Women's Leadership School of East Harlem (TYWLS) is a public all-girls school in East Harlem, Manhattan, New York City. The school serves approximately 440 young women in 6th through 12th grade. It is part of the Young Women's Leadership Network (YWLN). It was founded in 1996 by Ann and Andrew Tisch and New York City's Center for Education Innovation Public Education Association. They believed that it would help school families because in other public schools many girls weren't heard and the graduation rates were low. Then-Chancellor Rudy Crew led the project to the unanimous support of the New York City Board of Education.

Metropolitan Park is a former baseball ground located in East Harlem, Manhattan, New York. The ground was the part-time home to the New York Metropolitans of the American Association in 1884. The wooden ballpark was built a few blocks east and south from their first home, the original Polo Grounds, on a piece of land bounded by 109th Street (north), the Harlem River (east), 107th Street (south), and First Avenue (west). It was built a block east and north of the site of the Red House hotel and grounds, which had hosted trotting, cricket and baseball from 1833 until its demise in about 1867. The park had been built on a former dumping ground, a fact which contributed to its quick demise. It also suffered from the various swamp-related unpleasantries, such as mosquitoes, which had led to the shutdown of the Red House grounds. The Mets played their first game at Metropolitan Park on May 13, 1884, amid a degree of publicity. However, the park proved unsatisfactory, and was soon labeled "The Dump" by players and other observers (especially sports reporters working for the Brooklyn Eagle). The Mets returned to the Polo Grounds for games starting on July 17, 1884, except when the New York Giants were playing at home. The final Mets game played at Metropolitan Park was on August 23, 1884. The Mets then returned to their original Polo Grounds venue, in time to win the American Association pennant. The park continued to be used for occasional amateur baseball and football for a year or two after the Mets abandoned it. The block is now occupied by a complex of residential, commercial and school buildings.

The 1199 Plaza is a housing project in East Harlem. Located on First Avenue, on the western bank of the East River, the 1199 Plaza consists of four 31-story towers, joined by mid-rise units which extend toward the riverbank. 1199 Plaza opened in 1974, as a low-to-middle income housing project. The 1199 Plaza traces its origin to the 1199 union, which consisted mainly of female lower-income hospital workers. The 1199 union members wanted housing that was safe, affordable, and socially inclusive. Hodne/Stageberg Partners, Inc served as the architects of the project, while Ruberoid supplied building materials. In the 1990s, the 1199 Plaza began offering housing for non-HUD applicants. A new title, East River Landing, was adopted. The 1199 Plaza has thus become a hybrid project, housing both middle-income and higher-income applicants, in addition to poorer residents. The 1199 Plaza has been described as a "city within a city", owing to its sheer scale and unique design.

Thomas Jefferson Park is a 15.52-acre (6.28 ha) public park in the East Harlem neighborhood of Manhattan in New York City. The park is on First Avenue between 111th and 114th Streets. It contains a playground as well as facilities for baseball, basketball, football, handball, running, skating, and soccer. The Thomas Jefferson Play Center within the park consists of a recreation center and a pool. The park and play center, named for former U.S. president Thomas Jefferson, are maintained by the New York City Department of Parks and Recreation (NYC Parks). The land for the park was acquired starting in 1897. Though the park opened in 1902, the first recreational facilities did not open until 1905. The pool and bathhouse was designed by Stanley C. Brogren during a Works Progress Administration project in 1935–1936, while a playground next to the adjacent Benjamin Franklin High School opened in 1942. The pool was extensively refurbished in 1992, followed by the park in 1994. The Thomas Jefferson Play Center was designated a city landmark by the New York City Landmarks Preservation Commission in 2007.

Rao's () is a Southern Italian restaurant founded in 1896. It is located at 455 East 114th Street, on the corner of Pleasant Avenue in East Harlem, New York City. Rao's has sister restaurants in Los Angeles and Las Vegas, Nevada.

Manhattan Center for Science and Mathematics (abbreviated as MCSM) is a public high school at East 116th Street between Pleasant Avenue and FDR Drive in East Harlem, within Upper Manhattan, New York City. The school building, which was formerly Benjamin Franklin High School, was designated a New York City landmark by the New York City Landmarks Preservation Commission on May 29, 2018.

The Pontifical shrine of Our Lady of Mount Carmel is a Roman Catholic parish church under the authority of the Archdiocese of New York, located in East Harlem, Manhattan, New York City, United States. The church's formal address is 448 East 116th Street, although the entrance to the church building is on East 115th Street, just off Pleasant Avenue. The parish enshrines a vested statue of the Blessed Virgin Mary under the title of Our Lady of Mount Carmel, widely venerated by its devotees. Pope Leo XIII granted the image a Pontifical decree of Canonical Coronation on 12 May 1903. Pope Pius X carried over the Pontifical decree and donated a gemstone for the crown to which the rite of coronation was executed on 10 July 1904.

East River Plaza is a shopping mall located at FDR Drive near the Harlem River between 116th and 119th Street in East Harlem, New York City. Opened on November 12, 2009, after a protracted development process lasting 15 years, the mall has twelve stores with four anchor stores, which are Target, Costco, Burlington Coat Factory, and PetSmart. It has six levels and is attached to a parking garage.