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The Pontifical shrine of Our Lady of Mount Carmel is a Roman Catholic parish church under the authority of the Archdiocese of New York, located in East Harlem, Manhattan, New York City, United States. The church's formal address is 448 East 116th Street, although the entrance to the church building is on East 115th Street, just off Pleasant Avenue. The parish enshrines a vested statue of the Blessed Virgin Mary under the title of Our Lady of Mount Carmel, widely venerated by its devotees. Pope Leo XIII granted the image a Pontifical decree of Canonical Coronation on 12 May 1903. Pope Pius X carried over the Pontifical decree and donated a gemstone for the crown to which the rite of coronation was executed on 10 July 1904.

Manhattan Center for Science and Mathematics (abbreviated as MCSM) is a public high school at East 116th Street between Pleasant Avenue and FDR Drive in East Harlem, within Upper Manhattan, New York City. The school building, which was formerly Benjamin Franklin High School, was designated a New York City landmark by the New York City Landmarks Preservation Commission on May 29, 2018.

Thomas Jefferson Park is a 15.52-acre (6.28 ha) public park in the East Harlem neighborhood of Manhattan in New York City. The park is on First Avenue between 111th and 114th Streets. It contains a playground as well as facilities for baseball, basketball, football, handball, running, skating, and soccer. The Thomas Jefferson Play Center within the park consists of a recreation center and a pool. The park and play center, named for former U.S. president Thomas Jefferson, are maintained by the New York City Department of Parks and Recreation (NYC Parks). The land for the park was acquired starting in 1897. Though the park opened in 1902, the first recreational facilities did not open until 1905. The pool and bathhouse was designed by Stanley C. Brogren during a Works Progress Administration project in 1935–1936, while a playground next to the adjacent Benjamin Franklin High School opened in 1942. The pool was extensively refurbished in 1992, followed by the park in 1994. The Thomas Jefferson Play Center was designated a city landmark by the New York City Landmarks Preservation Commission in 2007.

The Young Women's Leadership School of East Harlem (TYWLS) is a public all-girls school in East Harlem, Manhattan, New York City. The school serves approximately 440 young women in 6th through 12th grade. It is part of the Young Women's Leadership Network (YWLN). It was founded in 1996 by Ann and Andrew Tisch and New York City's Center for Education Innovation Public Education Association. They believed that it would help school families because in other public schools many girls weren't heard and the graduation rates were low. Then-Chancellor Rudy Crew led the project to the unanimous support of the New York City Board of Education.

Patsy's Pizzeria is a historic coal-oven pizzeria in New York City. Opened in 1933, it was regarded as one of New York's original pizzerias for its use of traditional New York style thin crust pizza.

East River Plaza is a shopping mall located at FDR Drive near the Harlem River between 116th and 119th Street in East Harlem, New York City. Opened on November 12, 2009, after a protracted development process lasting 15 years, the mall has twelve stores with four anchor stores, which are Target, Costco, Burlington Coat Factory, and PetSmart. It has six levels and is attached to a parking garage.

The Church of the Holy Rosary was a Roman Catholic parish church under the authority of the Roman Catholic Archdiocese of New York, located at 444 East 119th Street, East Harlem, Manhattan, New York City. In November 2014, the Archdiocese announced that the Church of the Holy Rosary was one of 31 neighborhood parishes which would be merged into other parishes. Holy Rosary was merged into the Church of St. Paul at 113 East 117th Street.The church was deconsecrated on June 30, 2017.

The 1199 Plaza is a housing project in East Harlem. Located on First Avenue, on the western bank of the East River, the 1199 Plaza consists of four 31-story towers, joined by mid-rise units which extend toward the riverbank. 1199 Plaza opened in 1974, as a low-to-middle income housing project. The 1199 Plaza traces its origin to the 1199 union, which consisted mainly of female lower-income hospital workers. The 1199 union members wanted housing that was safe, affordable, and socially inclusive. Hodne/Stageberg Partners, Inc served as the architects of the project, while Ruberoid supplied building materials. In the 1990s, the 1199 Plaza began offering housing for non-HUD applicants. A new title, East River Landing, was adopted. The 1199 Plaza has thus become a hybrid project, housing both middle-income and higher-income applicants, in addition to poorer residents. The 1199 Plaza has been described as a "city within a city", owing to its sheer scale and unique design.

The 117th Street station was a local station on the demolished IRT Second Avenue Line in Manhattan, New York City. It had three tracks and two side platforms. The next stop to the north was 121st Street. The next stop to the south was 111th Street. The station closed on June 11, 1940.

116th Street is a planned station along the IND Second Avenue Line of the New York City Subway. It would be located at the intersection of Second Avenue and 116th Street in East Harlem, Manhattan. Proposed since 1968, the station is expected to be built as part of Phase 2 of the Second Avenue Subway. When opened, it will initially be served by the Q train, with the T train providing service when Phase 3 of the line is built.

Metropolitan Park is a former baseball ground located in East Harlem, Manhattan, New York. The ground was the part-time home to the New York Metropolitans of the American Association in 1884. The wooden ballpark was built a few blocks east and south from their first home, the original Polo Grounds, on a piece of land bounded by 109th Street (north), the Harlem River (east), 107th Street (south), and First Avenue (west). It was built a block east and north of the site of the Red House hotel and grounds, which had hosted trotting, cricket and baseball from 1833 until its demise in about 1867. The park had been built on a former dumping ground, a fact which contributed to its quick demise. It also suffered from the various swamp-related unpleasantries, such as mosquitoes, which had led to the shutdown of the Red House grounds. The Mets played their first game at Metropolitan Park on May 13, 1884, amid a degree of publicity. However, the park proved unsatisfactory, and was soon labeled "The Dump" by players and other observers (especially sports reporters working for the Brooklyn Eagle). The Mets returned to the Polo Grounds for games starting on July 17, 1884, except when the New York Giants were playing at home. The final Mets game played at Metropolitan Park was on August 23, 1884. The Mets then returned to their original Polo Grounds venue, in time to win the American Association pennant. The park continued to be used for occasional amateur baseball and football for a year or two after the Mets abandoned it. The block is now occupied by a complex of residential, commercial and school buildings.

St. Ann, The Personal School is a Catholic pre-kindergarten and K–8 school in Upper Manhattan, located in East Harlem at 314 East 110th Street, New York City. It was founded in 1926. The principal is Mrs. Teresa Letizia.