Harold D. Donohue Federal Building and United States Courthouse

Stevens' Building is a historic commercial building located at 24–44 Southbridge Street in downtown Worcester, Massachusetts. It is one of the city's most imposing mid-19th century buildings. The brick building is four stories for most of its length on Southbridge Street, and also presents a finished facade to Burnside Court. The central portion rises to a full five stories with a flat roof, while the north and south sections are four floors with a low pitch roof. The oldest portion of the building was the central portion, built sometime in the 1850s. The Stevens Brothers, manufacturers of wooden architectural building parts, purchased this building c. 1867, extended it northward to Burnside Court, and used it as factory space. By 1870 they had bought the land south of the building, and erected as a freestanding building seven bays of the present building. The two buildings were then joined together later in the 1870s. The fifth floor of the central section was probably added after a fire in the early 1900s.The building was listed on the National Register of Historic Places in 1980.

The Enterprise Building is an historic commercial building at 540 Main Street in Worcester, Massachusetts. When it was built in 1900, this five story brick building achieved notice for its elaborate Beaux Arts decorations. The building was listed on the National Register of Historic Places in 1980.

Colton's Block is an historic series of commercial buildings at 586-590 Main Street in Worcester, Massachusetts. Built in the 1860s, it consists of three separate yet similarly-styled buildings separated by firewalls. It is the only surviving example of a commercial building style that was common in Worcester at the time. The building was listed on the National Register of Historic Places in 1980. It is now mostly occupied by residences.

The Hanover Theatre and Conservatory for the Performing Arts in Worcester, Massachusetts, United States was originally built in 1904 as the Franklin Square Theatre regularly scheduling burlesque shows, Broadway touring shows and headline acts transitioning to showing silent films by 1912 when vaudeville magnate Sylvester Poli purchased the theatre from the estate of Pauline L. Taylor.

The Saint Joseph's Home for Working Girls is an historic social services building at 52 High Street in downtown Worcester, Massachusetts. Completed in 1924, it was operated for many years as a home for needy women by the Sisters of Mercy. Since 2009 it has been home to Abby's House, which continues the same mission. The building, designed by Edward Fitzgerald, was listed on the National Register of Historic Places in 2021.

The Cathedral of Saint Paul — informally known as Saint Paul's Cathedral — is the mother church of the Roman Catholic Diocese of Worcester. It is located at 38 Chatham Street in downtown Worcester, Massachusetts. Built between 1868 and 1889, it is one of the city's finest examples of Victorian Gothic architecture, and was listed on the National Register of Historic Places in 1980.

The Babcock Block is a historic commercial building at 596 Main Street in Worcester, Massachusetts. Built in the 1860s, it is a rare example of granite construction in the period. It was listed on the National Register of Historic Places in 1980.

The Worcester Market Building is a historic commercial building at 627 Main Street in Worcester, Massachusetts. When it was built in 1914, it was believed to be the largest grocery supply building in the nation. It was built for Fayette Asyril Amidon, who had founded the Worcester Market in 1894 after establishing a similar enterprise in Providence, Rhode Island. The building was designed by Oreste Ziroli, an Italian immigrant who worked as a draftsman for the building's builder, J. W. Bishop. The exterior of the building is terracotta that has been decorated with medallions on agricultural themes.The market was designed with modern (for the period) ideas of efficiency. The main floor, covering 25,000 square feet (2,300 m2), was devoted to retail space, and was designed to comfortably handle 4,500 customers. The basement and second floor were storage space, arranged so that supplies were located near their retail points on the main floor. These areas were connected to the main floor by elevators, eliminating the need for delivery vehicles to move in customer aisles.The building was listed on the National Register of Historic Places in 1980.

The Park Building is an historic building in Worcester, Massachusetts, USA. Built in 1914, the 11 story structure was for many years one of Worcester's most prominent landmarks. It has a steel frame, with an exterior that is dressed predominantly in limestone. The first two floors have metal and plate glass store fronts, while the third floor has evenly spaced windows, separated by decorative limestone panels and topped by a cornice. From the fourth to the ninth floors there is little decoration. The top two floors have groups of windows separated by Tuscan columns, giving the appearance of a loggia.The building was listed on the National Register of Historic Places in 1980. As of 2016 it is an apartment building known as Park Plaza that is part of the Grid District, a commercial urban redevelopment project in downtown Worcester.

The Grid District is a collection of buildings in downtown Worcester, Massachusetts.

The Printers Building is an historic commercial/industrial building at 44-50 Portland Street in downtown Worcester, Massachusetts. Completed in 1923 for a local printing industry trade group, it continues to serve that role under original ownership, and houses one of its original tenants. The building was listed on the National Register of Historic Places in 2020.

The Hadley Furniture Company Building is a historic retail building at 651-659 Main Street in downtown Worcester, Massachusetts. The five story brick building was built in 1923–24 to a design by the local architectural firm of Cutting, Carleton & Cutting. The Hadley Furniture Company, founded in 1914, sought to expand from earlier premises closer to City Hall, and commissioned its construction. As a representative of a significant specialty retail presence in the city, and for its architectural styling, it was listed on the National Register of Historic Places in 2011.