Chiquito River (Ponce, Puerto Rico)

Sexto (Barrio Sexto) is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Along with Primero, Segundo, Tercero, Cuarto, and Quinto, Sexto is one of the municipality's six core urban barrios. Barrio Sexto used to be called Barrio Cantera. It was organized in 1878.

The Acueducto de Ponce (Ponce Aqueduct), formally Acueducto Alfonso XII, is the name of a historic 2.5-mile gravity-based water supply system in the city of Ponce, Puerto Rico. It was designed in 1875 by Timoteo Luberza and built the following years. This aqueduct was the first modern water distribution system built in Puerto Rico. The Aqueduct (or, more precisely, its conduit channel at its highest elevation point in Barrio Mameyes) was known as El Puente de los Suicidios (Bridge of the suicides). It was declared a National Historic Monument on 17 June 2015.

The Tibes Indigenous Ceremonial Center (Spanish: Centro Ceremonial Indígena de Tibes) in Sector La Vega de Taní, Barrio Tibes, Ponce, Puerto Rico, houses one of the most important archaeological discoveries made in the Antilles. The discovery provides an insight as to how the indigenous tribes of the Igneri and Taínos lived and played during and before the arrival of Christopher Columbus to the New World. Tibes is the oldest Antillean Indian ceremonial and sports complex yet uncovered in Puerto Rico. Within its boundaries is also the largest indigenous cemetery discovered to date – consisting of 186 human skeletons, most from the Igneri and the rest from the pre-Taíno cultures. Based on the orientation of the ceremonial plazas, this is also believed to be the oldest astronomical observatory in the Antilles. The museum was established in 1982 and restored in 1991.

Portugués Urbano is one of the 31 barrios in the municipality of Ponce, Puerto Rico. Along with Canas Urbano, Machuelo Abajo, Magueyes Urbano, and San Antón, Portugués Urbano is one of the municipality's five originally rural barrios that are now also part of the urban zone of the city of Ponce. It was founded in 1953.

The Hotel Ponce Intercontinental (also known as "El Ponce") is an abandoned hotel with a still existing structure at Cerro del Vigía in Ponce, Puerto Rico. The structure is considered a historic landmark and a national icon in the city of Ponce and Puerto Rico. The property is currently owned by Misla Hospitality Group, a family of local Ponce investors who bought it from CBC Development. Its architecture is classical modern. When it opened, in 1960, it became the first modern hotel in the city.

The Antiguo Hospital Militar Español de Ponce (English: Old Spanish Military Hospital in Ponce) is a historic building in Ponce, Puerto Rico, in the city's historic district. The building dates from 1896 or 1897. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th Neoclassical architecture style. The building is of architectural significance since it is the only one-story building of this style remaining in the city of Ponce and one of the best examples on the Island. Completed in 1897, the year before the Spanish–American War of 1898, this building was the last major construction undergone by the Spanish Government in the Americas. From 1905 to the mid 1970s the structure served as the Asilo de Ciegos de Ponce (Ponce Blind Asylum). As of 2020 the building sits abandoned.

Castillo Serrallés (English: Serralles Castle) is a mansion located in the city of Ponce, Puerto Rico, overlooking the downtown area (Ponce Pueblo). It was built during the 1930s for Juan Eugenio Serrallés, son of businessman Juan Serrallés, founder of Destilería Serrallés. The structure sits on a 2.5-acre (1.0 ha) exceedingly manicured property. Nowadays, the structure functions as a museum, Museo Castillo Serrallés, with information about the sugar cane and rum industries and its impact in the economy of Puerto Rico. It is also increasingly used as a venue for social activities, including destination weddings. The property was listed in the National Register of Historic Places in 1980. In 1996, the structure was featured in the American TV series America's Castles.

Museo Castillo Serrallés (English: Serrallés Castle Museum), a.k.a. Museo de la Caña y el Ron (English: Sugar Cane and Rum Museum), is an agricultural museum in the city of Ponce, Puerto Rico, that showcases the history of sugar cane, its derivative rum industry, and their impact in the economy of Puerto Rico. The most notorious feature of the museum is the building it occupies. The building is a large four-story structure built in the 1930s for the owner of Ponce's Destileria Serralles, one of Puerto Rico's largest rum distilleries. The distillery was once also home to Puerto Rico's largest sugar-factory called Central Mercedita, producers of the Snow White sugar brand. The building, known as Castillo Serrallés, was designed by Pedro Adolfo de Castro in 1930 in the Spanish Colonial Revival style.The museum sits on a 2.5-acre lot and opened on 20 February 1991. Visitors can tour the refurbished home, which has been furnished to appear as it did in the 1930s. There is also a temporary exhibit area for local artists. The Serrallés Castle is now part of a large complex that includes the Cruceta El Vigía, a Japanese Garden, and a butterfly garden (Mariposario). By September 2010, the museum was receiving around 100,000 visitors per year.

Cruceta del Vigía (English: The Watchman Cross) is a 100 feet (30 m) tall cross located atop Cerro del Vigía in Ponce, Puerto Rico, across from Museo Castillo Serrallés. It houses a tourist center at its base, a ten-story vertical tower, and a horizontal sky bridge that has panoramic views of the city of Ponce and the Caribbean Sea. Visitors can reach the skybridge via glass elevators or a staircase. Made of reinforced concrete, the cross has withstood various natural disasters, including three major hurricanes. The arms of the cross measure 70 feet. It was inaugurated in 1984.One of many landmarks of the city of Ponce, the cross is owned by the Municipality of Ponce and is currently operated by the "Patronato de Ponce", a non-profit organization dedicated to preserving the city's cultural heritage. It is visited annually by some 100,000 tourists.

Cerro del Vigía is a hill in the municipality of Ponce, Puerto Rico, located just north of the city of Ponce. A tourist destination, it is home to Museo Castillo Serrallés, Cruceta del Vigía, and the former Hotel Ponce Intercontinental. The 456-foot high hill sits at the foothills of the Cordillera Central and is located in Barrio Portugués Urbano. The hill is home to several well-to-do mansions of which the best known is Castillo Serrallés, now a Museum.

Albergue Caritativo Tricoche or Hospital Tricoche (English: Tricoche Charitable Shelter or Tricoche Hospital) is a historic building located on Calle Tricoche street in Ponce, Puerto Rico, in the city's historic district. It was designed by the Spanish Royal Corps of Engineers. The architecture consists of 19th-century civil architecture. When built in 1878, "it held the top spot among public building in Puerto Rico," based on its size and beauty.The hospital was named after Valentin Tricoche, a 19th-century philanthropist and land owner in Ponce with lands on the western bank of Rio Bucana which included lands with a stone mine. Valentin Tricoche left moneys in his will for the construction of the hospital. Construction started on 30 May 1873, it was delivered to the Municipal government by the Spanish Royal Corps of Engineers in September 1876, and opened to the public on 11 December 1878. The structure was built articulated in the Classical revival style. By 1885, the hospital was expanded with an annex which was named "Hospital Civil de Ponce", to differentiate it from the original hospital built with funds from Valentin Tricoche.The historic structure was listed on the U.S. National Register of Historic Places on 14 May 1987.

Puente La Milagrosa is a historic bridge in Ponce, Puerto Rico. The Art Deco bridge carries two lanes of vehicular traffic for the two-way Calle Guadalupe (PR-14R). It runs west to east and crosses Río Portugués connecting Barrio Quinto in the west to Barrio Machuelo Abajo in the east. It is located 0.7 km northeast of Plaza Las Delicias. It is part of the historic Carretera Central.