University of Pittsburgh Medical Center

The Pennsylvania Canal Tunnel was the Pittsburgh terminus of the Pennsylvania Main Line of Public Works, a transportation system that involved other early tunnels. Construction was authorized February 8, 1827, and the tunnel was completed November 10, 1829. The canal crossed the Allegheny River on a covered bridge aqueduct, later replaced by John A. Roebling's first suspension bridge, the Allegheny Aqueduct., the canal traveled underground through most of downtown Pittsburgh, under Grant's Hill, to end in a lock leading to the Monongahela River. The original plan was to connect with the C&O canal at the Monongahela River, but that canal never reached its expected western end, and the tunnel's main use was to allow overflow from the canal to enter the Monongahela. Only one or two canal boats ever went through the tunnel and lock. The tunnel was made obsolete by the arrival of the Pennsylvania Railroad in 1852. The canal tunnel was uncovered during the construction of the U.S. Steel Tower in 1967, and later during the construction of the subway system, which used part of the tunnel on the south side.

The U.S. Steel Tower, also known as the Steel Building or USX Tower (1988–2001), is a 64-story skyscraper at 600 Grant Street in downtown Pittsburgh, Pennsylvania. The interior has 2,300,000 sq ft (210,000 m2) of leasable space. Standing 841 ft (256 m) tall, it is the tallest building in Pittsburgh, the fifth-tallest in Pennsylvania, the 69th-tallest in the United States, and the 200th-tallest in the world. It held its opening dedication on September 30, 1971.The tower's original name when completed was the U.S. Steel Tower and was changed to USX Tower in 1988. The name was changed back to the U.S. Steel Tower in January 2002 to reflect U.S. Steel's new corporate identity (USX was the 1990s combined oil/energy/steel conglomerate). Although no longer the owner of the building, U.S. Steel remains one of the largest tenants.

Koppers Building is a historical building in Pittsburgh, Pennsylvania, commissioned by Andrew W. Mellon and completed in 1929. The building is named after the Koppers Chemical Corporation and is one of the major features of Downtown Pittsburgh.

The Gulf Tower is a 44-story, 177.4 m (582 ft) Art Deco skyscraper in downtown Pittsburgh, Pennsylvania. The tower is one of the major distinctive and recognizable features of the city and is named for the Gulf Oil Corporation, one of the leading multinational oil companies of its time, and one of the Seven Sisters of the Anglo-American oil industry prior to its merger with fellow oil giantChevron. Built as the headquarters for the Gulf Oil Company, the structure was designed by the firm of Trowbridge & Livingston and completed in 1932 at a cost of $10.05 million ($163 million today). As late as 1981 Gulf Oil employed 3,100 within the building. Now called Gulf Tower, it has 44 floors and rises 177.4 m (582 ft) above Downtown Pittsburgh. The crown of the skyscraper is modeled after the Mausoleum of Halicarnassus in the style of a step pyramid. The building was listed as a Pittsburgh History & Landmarks Foundation Historic Landmark in 1973.On June 13, 1974, a bomb was detonated on the 29th floor of the Gulf Tower. The Weather Underground Organization took credit for the attack, claiming it was in protest to Gulf Oil's involvement in the oil rich regions affected by the Angolan War of Independence. The building was condemned following a fire on May 19, 2021 and required repairs. The Gulf Tower reopened to tenants and visitors six months later.

The Federal Reserve Bank of Cleveland Pittsburgh Branch Office is one of two Federal Reserve Bank of Cleveland branch offices (the other is in Cincinnati). The Pittsburgh Office of the Federal Reserve Bank of Cleveland hosts one of two savings bonds processing sites in the nation. The Pittsburgh branch presides over Jefferson, Monroe and Belmont counties in Ohio, Wetzel, Tyler, Pleasants, Marshall, Ohio, Brooke and Hancock counties in West Virginia, and all of Western Pennsylvania. In 1915 it was revealed that the Pittsburgh branch location was to be the new home of a relocated Cleveland Fed District with a majority vote secured on the board of governors, but the U.S. Attorney General at the time nixed moving the Cleveland, Kansas City, Minneapolis, Boston and Atlanta Federal Reserve Districts, stating that it would instead take an act of Congress to move those district headquarters. Pittsburgh remained a branch location only.

The James Reed Building or the Reed Smith Building is a historic building in Pittsburgh. It was constructed in 1902. It is in the Beaux-Arts architecture style. For many years, the primary tenant had been Reed Smith law firm. The buildings namesake is one of Reed Smiths founders, James Hay Reed. Reed Smith bought the nine-story building in 1984 for $5.82 million as 435 Sixth Ave Associates. In 2007 Reed Smith decided to relocate its corporate headquarters to Three PNC Plaza and sell the building, which had a market value of $16.78 million. The downtown Pittsburgh office vacancy rate at the time was 20%, driving down the value of the building. In October 2008, the building was purchased by Mika Realty Group of Los Angeles for $6.5 million. Mika Realty, owned by Michael Kamen and Gerson Fox, purchased the building under the name 600 William Penn Partners LLC. Kamen and Fox also purchased the nearby Union Trust Building 6 months prior.In 2009, Reed Smith law firm moved its corporate headquarters to Three PNC Plaza. Mika Realty was never able to find a tenant to replace Reed Smith, the building remained vacant, which led to bankruptcy in 2011. PMC Property Group purchased the building in September 2012 for $5.5 million in a U.S. Bankruptcy Court auction in Los Angeles.The building was redeveloped into a 249-room Hotel Monaco, opened in January 2015.

The Joseph F. Weis, Jr. U.S. Courthouse is a Beaux Arts-style building in Pittsburgh, Pennsylvania, US. It is a courthouse for the Western District of Pennsylvania, a United States district court. Until 2015, the building was known as the US Post Office and Courthouse-Pittsburgh.

The Allegheny HYP Club (Harvard-Yale-Princeton Club) is a private social club in downtown Pittsburgh, Pennsylvania. Located at 617-619 William Penn Place, it was built in 1894 and was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 2002. On July 1, 1997, the club absorbed the Pittsburgh Club membership and assets.The Pittsburgh Harvard-Yale-Princeton Club was formally founded on November 7, 1930. The club merged with the Three Rivers Stadium based Allegheny Club in 2002 after Allegheny had filed for bankruptcy protection.

The Bell Telephone Building is a 339-foot (103 m) art deco skyscraper in Downtown Pittsburgh, Pennsylvania. It was completed in 1923 and has 20 floors. It is the 22nd-tallest building in the city.

The Pittsburgh & Steubenville Extension Railroad Tunnel, also known as the Panhandle Tunnel, was originally built for the Pittsburgh and Steubenville Extension Railroad in Pittsburgh. It officially opened for rail traffic in 1865.

Steel Plaza is a station on the Pittsburgh Regional Transit's light rail network, located in Pittsburgh, Pennsylvania. It serves the city's Downtown district and is located at the intersection of Grant Street and Oliver Avenue. The station consists of an outbound (southbound) side platform and an inbound island platform, with one track for trains to Wood Street and the other for a disused branch line to Union Station. The station has rights to 4.25 acres underground Mellon Green and is accessible by means of a tunnel that connects BNY Mellon Center and the US Steel Tower. The busiest station in the system, it provides access to eastern and central portions of downtown, including the city's tallest buildings, the US Steel Tower and BNY Mellon Center. Major office buildings including the Gulf Tower, 525 William Penn Place, and the Koppers Building are also only a block away, along with the many early 20th-century skyscrapers that make up downtown's inner core. The city's Uptown (commonly known as The Bluff) neighborhood, which includes PPG Paints Arena and Duquesne University is also within a short walk.

The William S. Moorhead Federal Building is a 340-foot (100 m) tall skyscraper in downtown Pittsburgh, Pennsylvania, United States. Plans for the building were announced on November 9, 1958, and the structure was completed in 1964. It has 23 floors and is the 21st tallest building in Pittsburgh.