William S. Moorhead Federal Building

The Federal Reserve Bank of Cleveland Pittsburgh Branch Office is one of two Federal Reserve Bank of Cleveland branch offices (the other is in Cincinnati). The Pittsburgh Office of the Federal Reserve Bank of Cleveland hosts one of two savings bonds processing sites in the nation. The Pittsburgh branch presides over Jefferson, Monroe and Belmont counties in Ohio, Wetzel, Tyler, Pleasants, Marshall, Ohio, Brooke and Hancock counties in West Virginia, and all of Western Pennsylvania. In 1915 it was revealed that the Pittsburgh branch location was to be the new home of a relocated Cleveland Fed District with a majority vote secured on the board of governors, but the U.S. Attorney General at the time nixed moving the Cleveland, Kansas City, Minneapolis, Boston and Atlanta Federal Reserve Districts, stating that it would instead take an act of Congress to move those district headquarters. Pittsburgh remained a branch location only.

The Joseph F. Weis, Jr. U.S. Courthouse is a Beaux Arts-style building in Pittsburgh, Pennsylvania, US. It is a courthouse for the Western District of Pennsylvania, a United States district court. Until 2015, the building was known as the US Post Office and Courthouse-Pittsburgh.

The Westin Convention Center Pittsburgh is a 26-story, hotel in Downtown Pittsburgh, with a prominent position in the area adjacent to the David L. Lawrence Convention Center and the Cultural District. The hotel is connected via an enclosed walkway to the convention center. The building is part of Liberty Center, a two building complex which also includes the Federated Tower. Liberty Center was developed and built by Liberty Center Ventures, a partnership of Forest City Enterprises and Jos. L. Muscarelle, Inc. and opened in December 1986. In August 2013, Liberty Center was sold by Forest City to Starwood Capital Group for $135 million.

Federated Tower is a 358 ft (109 m) tall skyscraper in Pittsburgh, Pennsylvania. The building is part of Liberty Center, a two building complex which also includes the Westin Convention Center Hotel. It was completed in 1986 and has 27 floors and 530,000 square feet of space. It is the 16th tallest building in the city and houses the corporate headquarters of Federated Investors. Liberty Center was developed and built by Liberty Center Ventures, a partnership of Forest City Enterprises and Jos. L. Muscarelle, Inc. and opened in December 1986. The $137 million mixed-use complex was the first major development following the Renaissance II burst of construction in downtown Pittsburgh. The entire Liberty Center complex opened in December 1986. The complex was financed from three sources: a $99 million loan from Metropolitan Life Insurance Company, a $21 million from the Pittsburgh Urban Redevelopment Authority, and the remainder from Jos. L. Muscarelle, Inc. and Forest City Enterprises.In August 2013 the tower was sold by Forest City to Starwood Capital Group for $135 million.On February 18, 2014 the tower opened the newly relocated downtown Post Office on the lobby floor.In January 2017, CBRE Global Investors purchased the Federated Tower for an estimated $98 million. The purchase did not include the adjacent Westin Convention Center Hotel, which was part of the 2013 by Starwood Capital Group.

The Gulf Tower is a 44-story, 177.4 m (582 ft) Art Deco skyscraper in downtown Pittsburgh, Pennsylvania. The tower is one of the major distinctive and recognizable features of the city and is named for the Gulf Oil Corporation, one of the leading multinational oil companies of its time, and one of the Seven Sisters of the Anglo-American oil industry prior to its merger with fellow oil giantChevron. Built as the headquarters for the Gulf Oil Company, the structure was designed by the firm of Trowbridge & Livingston and completed in 1932 at a cost of $10.05 million ($163 million today). As late as 1981 Gulf Oil employed 3,100 within the building. Now called Gulf Tower, it has 44 floors and rises 177.4 m (582 ft) above Downtown Pittsburgh. The crown of the skyscraper is modeled after the Mausoleum of Halicarnassus in the style of a step pyramid. The building was listed as a Pittsburgh History & Landmarks Foundation Historic Landmark in 1973.On June 13, 1974, a bomb was detonated on the 29th floor of the Gulf Tower. The Weather Underground Organization took credit for the attack, claiming it was in protest to Gulf Oil's involvement in the oil rich regions affected by the Angolan War of Independence. The building was condemned following a fire on May 19, 2021 and required repairs. The Gulf Tower reopened to tenants and visitors six months later.

The August Wilson African American Cultural Center is a U.S. nonprofit arts organization based in Pittsburgh, Pennsylvania that presents performing and visual arts programs that celebrate the contributions of African Americans not only in Western Pennsylvania, but nationally and internationally. The August Wilson African American Cultural Center building is on Liberty Avenue in Downtown Pittsburgh's Cultural District. It includes galleries, classrooms, a 500-seat theater, a gift shop, a cafe, and many multi-purpose spaces for visual and performing art. The museum opened in 2009.

The Stadium Authority of the City of Pittsburgh (also known as the Stadium Authority) is a municipal authority that was charged with the construction of Three Rivers Stadium and the management of the land on which it stood following its 2001 demolition.It currently owns the West General Robinson Street Garage and surface parking lots near PNC Park and Heinz Field. The Stadium Authority also leases parking facilities north of PNC Park. It was formed on March 9, 1964 by the City of Pittsburgh under its authority under the Public Auditorium Authorities Law of the Commonwealth of Pennsylvania. The Stadium Authority board is comprised on five members, all appointed by the Mayor of Pittsburgh. In 2003, the Stadium Authority began a development project in an area called the "Option Area" that allowed the Pittsburgh Steelers and the Pittsburgh Pirates to develop commercial property in conjunction with North Shore Developers. The plan currently has completed the Equitable Resources building and the Del Monte Building.The Pittsburgh Intergovernmental Cooperation Authority, a special administrative authority that supervises the finances of the City of Pittsburgh, has said that the Stadium Authority is no longer necessary and recommended in 2004 that its duties be consolidated into the Sports & Exhibition Authority of Pittsburgh and Allegheny County. However, as of 2016, the Stadium Authority still exists and continues to manage parking lots in the North Shore area. This incongruity has led to some wry attention from local journalists and pundits—for example, University of Pittsburgh economist Chris Briem has referred to it as the "Stadium(less) Authority".

Koppers Building is a historical building in Pittsburgh, Pennsylvania, commissioned by Andrew W. Mellon and completed in 1929. The building is named after the Koppers Chemical Corporation and is one of the major features of Downtown Pittsburgh.

The Grant Street Transportation Center is an intercity bus station in downtown Pittsburgh.

The University of Pittsburgh Medical Center (UPMC) is a $23 billion integrated global nonprofit health enterprise that has 92,000 employees, 40 hospitals with more than 8,000 licensed beds, 800 clinical locations including outpatient sites and doctors' offices, a 3.8 million-member health insurance division, as well as commercial and international ventures. It is closely affiliated with its academic partner, the University of Pittsburgh. It is considered a leading American health care provider, as its flagship facilities have ranked in U.S. News & World Report "Honor Roll" of the approximately 15 to 20 best hospitals in America for over 15 years. As of 2016, its flagship hospital UPMC Presbyterian is ranked 12th nationally among the best hospitals (and first in Pennsylvania) by U.S. News & World Report and ranked in 15 of 16 specialty areas when including UPMC Magee-Womens Hospital. This does not include UPMC Children's Hospital of Pittsburgh which ranked in the top 10 of pediatric centers in a separate US News ranking.

The Pennsylvania Canal Tunnel was the Pittsburgh terminus of the Pennsylvania Main Line of Public Works, a transportation system that involved other early tunnels. Construction was authorized February 8, 1827, and the tunnel was completed November 10, 1829. The canal crossed the Allegheny River on a covered bridge aqueduct, later replaced by John A. Roebling's first suspension bridge, the Allegheny Aqueduct., the canal traveled underground through most of downtown Pittsburgh, under Grant's Hill, to end in a lock leading to the Monongahela River. The original plan was to connect with the C&O canal at the Monongahela River, but that canal never reached its expected western end, and the tunnel's main use was to allow overflow from the canal to enter the Monongahela. Only one or two canal boats ever went through the tunnel and lock. The tunnel was made obsolete by the arrival of the Pennsylvania Railroad in 1852. The canal tunnel was uncovered during the construction of the U.S. Steel Tower in 1967, and later during the construction of the subway system, which used part of the tunnel on the south side.

ToonSeum: Pittsburgh Museum of Cartoon Art is a museum devoted exclusively to the cartoon arts, located in Pittsburgh, Pennsylvania. ToonSeum is one of three museums dedicated to cartoon art in the United States. ToonSeum moved to its own gallery space on Liberty Avenue in Pittsburgh's downtown Cultural District on November 8, 2009, aided by the Pittsburgh Cultural Trust. It is currently led by John Kelly.In 2009, the ToonSeum established its NEMO Award, given to notable individuals "for excellence in the cartoon arts". Recipients to date include veteran comic-book artist Ron Frenz, editorial and comic-strip artist Dick Locher, and comics artist, editorial cartoonist and artists' rights advocate Jerry Robinson. In May 2013, ToonSeum hosted the two-day North American Conference of the National Cartoonists Society. In that same month, plans for expansion of the museum were announced.On February 16, 2018, the ToonSeum announced on their Facebook page that they would close the physical location on Liberty avenue February 24, 2018 to focus on direct community outreach.