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Hanover House is a colonial house built by a French Huguenot family in 1714–1716, on the upper Cooper River in present-day Berkeley County of the South Carolina Low Country. The house is also known as the St. Julien-Ravenel House after its early owners. When a state project to dam the river was dammed and create Lake Moultrie was proposed in the 1940s, it would have flooded the site of the house. To preserve the historic structure, the house was moved to the Clemson University campus in Pickens County.

Old Stone Church is a church building built in 1802. When it was constructed, it was in the Pendleton District, South Carolina. When Pendleton District was divided in 1826, the church was in Pickens District. When Pickens District was split in 1868, it was in Oconee County, South Carolina. In 1968, this section of Oconee County was annexed back to Pickens County. The church is about midway between the centers of Pendleton and Clemson. It is now in the city limits of Clemson.

The South Carolina Botanical Garden (295 acres) is located in Clemson, South Carolina on the campus of Clemson University. This garden has nature trails, pathways, ponds, streams, woodlands, trial gardens, The Bob Campbell Geology Museum, and the Fran Hanson Discovery Center, which has exhibits by local artists. It is open to the public every day of the week. The Bob Campbell Geology Museum features more than 10,000 rocks, minerals and fossils and has exhibits focused on geological and paleontological topics. The gardens are the home of the historic Hanover House, which is an early 18th-century house built in the South Carolina Low Country and moved to the Clemson campus. It also has a pioneer village featuring the Hunt Log Cabin, which was originally built about 1825 in the Seneca, South Carolina area. The South Carolina Botanical Garden features one of the largest collections of nature-based sculptures in the country. The extended-ephemeral pieces were each designed on-site by international artists and built by local volunteers and students within one month. Upon completion, the pieces begin to return to nature, so while many may still be found in the Garden, others have disappeared without a trace.

Clemson Experimental Forest, a 17,500 acre forest surrounding Clemson University, is a natural resource laboratory. It is a product of a land reclamation project funded by Franklin D. Roosevelt Administration's New Deal programs. The forest is habitat for more than 195 species of birds and more than 90 species of trees. The forest is used for research, education, and recreation.

Clemson ([note a]) is a city in Pickens and Anderson counties in the U.S. state of South Carolina. Clemson is home to Clemson University; in 2015, the Princeton Review cited the town of Clemson as ranking #1 in the United States for "town-and-gown" relations with its resident university. The population of the city was 17,681 at the 2020 census.Clemson is part of the Greenville-Spartanburg-Anderson, SC Combined Statistical Area. Most of the city is in Pickens County, which is part of the Greenville-Mauldin-Anderson Metropolitan statistical area. A small portion is in Anderson County.

The Clemson College Sheep Barn (Barnes Center) is a two-story barn built in 1915 on the Clemson University campus. It is the oldest surviving building associated with agriculture on this land-grant university. It was named to the National Register of Historic Places on January 4, 1990.

The President's House was built in 1959 to serve as the living quarters for the president at Clemson University in Clemson, South Carolina, USA. It has been the home to eight different Clemson presidents and is a key location on the university's campus. This is especially the case for new and incoming students because at the beginning of each year, new students are invited to a picnic on the president's lawn in front of the house. This gives students the chance to meet the president for the first time. The house is located at 120 Cherry Road in Clemson. When arriving at campus from I-85 (SC) it is the first building people see. At night, the building has an image projected on to it in Clemson orange of the Tiger Paw logo.

The J. C. Stribling Barn is a brick barn built ca. 1890 to 1900 at 220 Isaqueena Trail in Clemson, South Carolina. It is also known as the Sleepy Hollow Barn or the Stribling-Boone Barn. It was named to the National Register of Historic Places on October 22, 2001.

Clemson House was a hotel and later a residence hall located on the campus of Clemson University in Clemson, South Carolina, USA. It was built in 1950 and demolished by controlled implosion in 2017.

The Clemson University Historic District I is a collection of historic properties on the campus of Clemson University in Clemson, South Carolina. The district contains eight contributing properties located along the northern portion of the campus. Included are some of the oldest academic buildings on campus. It was listed on the National Register of Historic Places in 1990.

Lee and Lowry Hall, originally known as the Structural Science Building, is a historic academic building located on the campus of Clemson University, Clemson, Pickens County, South Carolina. It was designed by Harlan Ewart McClure, Dean of the College of Architecture, and completed in 1958. It consists of three building elements that enclose two courtyards: the Civil Engineering Wing, the Mechanical Engineering Laboratories, and the Architecture Wing. The buildings are in the International Style.It was listed on the National Register of Historic Places in 2010.

The Clemson University Historic District II is a collection of historic properties on the campus of Clemson University in Clemson, South Carolina. The district contains 7 contributing properties located in the central portion of the campus. It was listed on the National Register of Historic Places in 1990.