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Brussels-South railway station (French: Gare de Bruxelles Midi, Dutch: Station Brussel-Zuid, IATA code: ZYR), officially Brussels-South (French: Bruxelles-Midi, Dutch: Brussel-Zuid), is a major railway station in Brussels, Belgium. Geographically, it is located in Saint-Gilles/Sint-Gillis on the border with the adjacent municipality of Anderlecht and just south of the City of Brussels. Brussels-South is one of over a dozen railway stations in Brussels, and one of the three principal rail stations in the heart of the city, the two others being Brussels-Central and Brussels-North. The station, which was a terminus when it was inaugurated in 1869, became a transit station with the opening of the North–South connection in 1952. Nowadays, it is the busiest station in Belgium, and is the only Brussels stop of international high speed rail services: Eurostar, Thalys and ICE. Underneath Brussels-South is the rapid transit Gare du Midi/Zuidstation station on lines 2, 3, 4 and 6 of the Brussels Metro and premetro (underground tram) systems, which serves as an important node of the Brussels Intercommunal Transport Company (STIB/MIVB).

Anderlecht (French: [ɑ̃dɛʁlɛkt], Dutch: [ˈɑndərlɛxt] (listen)) is one of the 19 municipalities of the Brussels-Capital Region, Belgium. Located in the south-western part of the region, it is bordered by the City of Brussels, Forest, Molenbeek-Saint-Jean, and Saint-Gilles, as well as the Flemish municipalities of Dilbeek and Sint-Pieters-Leeuw. In common with all of Brussels' municipalities, it is legally bilingual (French–Dutch). There are several historically and architecturally distinct districts within Anderlecht. As of 1 January 2020, the municipality had a population of around 120,887. The total area is 17.74 km2 (6.85 sq mi), which gives a population density of 6,749/km2 (17,480/sq mi). Its upper area is greener and less densely populated.

The Avenue Fonsny (French) or Fonsnylaan (Dutch) is a major street in the Saint-Gilles municipality of Brussels, Belgium, connecting the Place de la Constitution/Grondwetplein on the south-west of the Small Ring to the municipality of Forest. It is continued in Forest by the Avenue Van Volxem/Van Volxemlaan. It runs parallel to the Belgian railway line 96. One entry to Brussels-South railway station is on the Avenue Fonsny.

Cureghem (French) or Kuregem (Dutch) is a district of Anderlecht, a municipality of Brussels, Belgium. Located in the east of Anderlecht, it is one of this municipality's largest and most populated districts. It developed during the Industrial Revolution along the Brussels–Charleroi Canal and is currently in a fragile social and economic situation due to the decline of its economy and the poor quality of some of its housing.

The Tour du Midi (French) or Zuidertoren (Dutch), both meaning South Tower, is a 38-storey, 148 m (486 ft) skyscraper constructed between 1962 and 1967 in Brussels, Belgium. The tower is the tallest building in Belgium, and was the tallest in the European Economic Community when it was built until it was surpassed by Tour Montparnasse in Paris in 1972. Tour du Midi stands adjacent to Brussels-South railway station. The building's facade was reclad in 1995-1996 with unitised glass panels using double glass solarbel silver, and it can accommodate about 2,500 office workers. It was built for the Belgian Pensions Administration, which still occupies it today.

The Synagogue of Anderlecht is an Orthodox Synagogue in the municipality of Anderlecht, Brussels, Belgium. Located at the heart of the former Jewish quarter of Anderlecht, the synagogue is the main synagogue of the Orthodox Community of Brussels (French: Communauté Israélite Orthodoxe de Bruxelles (CIOB).

The Municipal Hall (French: Hôtel communal, Dutch: Gemeentehuis) of Anderlecht is the municipal hall building and the seat of that municipality of Brussels, Belgium. Designed by the architect Jules Jacques Van Ysendyck in neo-Flemish Renaissance style, it is located at 1, place du Conseil/Raadsplein in Cureghem. This site is served by Brussels-South railway station, as well as the tram stop Conseil/Raad (on line 81).

Clemenceau is a Brussels metro station on the southern segment of lines 2 and 6. It is located on Rue Jorez/Jorezstraat, close to Avenue Clemenceau/Clemenceaulaan, in the municipality of Anderlecht, in the western part of Brussels (Belgium). It opened on 18 June 1993 and was the terminus of line 2 until Delacroix opened in 2006. It is named after the nearby avenue, itself named after Georges Clemenceau, a former Prime Minister of France.

Brasserie-Brouwerij Cantillon ("Brewery Cantillon") is a small Belgian traditional family brewery based in Anderlecht, Brussels. Cantillon was founded in 1900 and brews exclusively lambic beers.

The National Museum of the Resistance (French: Musée national de la Résistance, Dutch: Nationaal Museum van de Weerstand) is a museum located in Anderlecht, a municipality of Brussels, Belgium. The museum traces the history of the Belgian Resistance and German occupation of Belgium during World War II. It is served by Clemenceau metro station on lines 2 and 6 of the Brussels Metro.

The Square de l'Aviation (Dutch: Luchtvaartsquare), meaning "Aviation Square", is a square located in the Brussels municipality of Anderlecht, Belgium. The Centre for Historical Research and Documentation on War and Contemporary Society (Cegesoma or CegeSoma) is located on this square. The Square de l'Aviation is bounded to the east by the Boulevard Poincaré/Poincarélaan and extended, to the west, by the Rue Lambert Crickx/Lambert Crickxstraat on the odd side and the Rue de l'Autonomie/Zelfbestuursstraat on the even side. The angle of the two streets forms a cutaway. This area is served by Brussels-South railway station.

Matteo Ricci College (French: Collège Matteo Ricci) is a Mixed Catholic secondary school in Anderlecht, Brussels, Belgium. It opened in September 2019 and is a Jesuit college, the first Jesuit school to be opened in Belgium in the 21st century. It is located on Boulevard Poincaré, 400 metres north east of Brussels-South railway station.