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Antioch University New England is a private graduate school located in Keene, New Hampshire, United States. It is part of the Antioch University system, a private, non-profit, 501(c)(3) institution that includes campuses in Seattle, Washington; Los Angeles, California; and Santa Barbara, California. It is accredited by the Higher Learning Commission. The most well-known campus was Antioch College in Yellow Springs, Ohio, which is now independent of the Antioch University system.

The Faulkner & Colony Woolen Mill is an historic mill building located at 222 West Street in Keene, New Hampshire. It was added to the National Register of Historic Places (NRHP) in 2020.The main building was constructed in 1838 and was subsequently expanded in 1859. The mill was named after Francis Faulkner and Josiah Colony, who owned multiple mills along the Ashuelot River. In addition to the main mill building, a former boarding house (built 1810) and a storehouse (built 1859) are included in the NRHP listing. The mill provided material for many uses, including to the U.S. military during the Civil War, World War I, and World War II.Mid-20th century developments in synthetics caused the mill to close in 1954, making it the longest running family-owned textile mill in the country. The property was converted to retail and office space in 1983 and was later converted into residential apartments.

Keene High School (KHS) is a public high school located in Keene, New Hampshire. It serves the city of Keene and the surrounding towns of Chesterfield, Harrisville, Marlborough, Marlow, Nelson, Stoddard, Sullivan, Surry, Westmoreland and Winchester. The Cheshire Career Center, a co-curricular and community education center, is located in the South Annex of the building. As of the 2014–15 school year, the school had an enrollment of approximately 1,391 students and 121.8 classroom teachers (on a FTE basis), for a student-teacher ratio of 11.0.

WKBK (1290 AM) is a radio station broadcasting a news/talk format. Licensed to Keene, New Hampshire, United States, the station is owned by Saga Communications and licensed to Saga Communications of New England, LLC; it operates as part of Saga's Monadnock Broadcasting Group. WKBK features programming from CBS News Radio, NBC News Radio, Compass Media Networks, Salem Radio Network, and Westwood One.

The Colony House is a historic house at 104 West Street in Keene, New Hampshire. Built in 1819 and enlarged about 1900, it is a good example of Federal period architecture, and is notable for its association with Horatio Colony, a prominent local businessman and the city's first mayor. The house, now operated as a bed and breakfast inn, was listed on the National Register of Historic Places in 2005.

The Sawyer Tavern is a historic building at 63 Arch Street in Keene, New Hampshire. Probably built c. 1803–06, it was long a neighborhood landmark, serving as a tavern and then inn and restaurant for parts of the 19th and 20th centuries. The building is now in residential use. It was listed on the National Register of Historic Places in 1980, and the New Hampshire State Register of Historic Places in 2007.

The Cheshire County Courthouse, located at 12 Court Street in Keene, New Hampshire, is the center of government of Cheshire County, New Hampshire. Completed in 1859 to a design by Gridley James Fox Bryant, it is believed to be the oldest courthouse in regular use in the state. It was added to the National Register of Historic Places on December 13, 1978.

Cheshire Medical Center is the only hospital in Cheshire County, New Hampshire, United States. The 115-bed hospital is located in the city of Keene, the Cheshire County seat. It is part of the Dartmouth–Hitchcock health care network.It was built in 1973 and replaced the Elliot Community Hospital on Main Street which had served as the city's hospital since 1892.

Grace United Methodist Church is a historic Methodist Church building at 34 Court Street in Keene, New Hampshire. Built in 1869, it was designed by architect Shepard S. Woodcock, and is one of the largest churches in southwestern New Hampshire. It was added to the National Register of Historic Places in 1985. Its congregation moved in 2009 and was disbanded in 2016, and the building is (as of 2018) undergoing renovation for use as professional offices.

The New Hampshire Superior Court is the statewide court of general jurisdiction which provides jury trials in civil and criminal cases. There are 11 locations of the Superior Court, one for each county and two in Hillsborough County.

The Cohen Center for Holocaust and Genocide Studies is one of the oldest Holocaust resource centers in the United States. Founded in 1983, the center is located at Keene State College in New Hampshire. The center was founded by Dr. Charles Hildebrandt.

Alumni Field is a baseball field located in Keene, New Hampshire, United States. The field, located on Arch Street, was constructed in 1948 and has served as the home of the Keene Swamp Bats of the New England Collegiate Baseball League since the 1997 NECBL season. The field is part of the athletic facilities at Keene High School and is owned by the Alumni Association. The football, soccer, and track & field teams of Keene High School also use the facility. It holds a capacity of approximately 4,100 fans. Wilson Pond is located next to the field on the first base side. Alumni Field features three separate seating structures. The main, covered seating section is located on the first base side. On the third base side, a large, uncovered bleacher-style stand has 15 rows of seating. The third section is located behind home plate, a pair of smaller uncovered bleacher seating structures.Alumni Field hosted the 2006 NECBL All-Star Game. The game, attended by 3,183 fans, was won by the visiting Northern Division 6–2.