Michigan Science Center

The Charles H. Wright Museum of African American History, or The Wright, is located in Detroit, Michigan in the US; inside the city's Midtown Cultural Center is one of the world's oldest independent African-American museums. Founded in 1965, The Wright museum holds the world's largest permanent collection of African-American culture. With a collection of more than 35,000 artifacts, The Wright's current 125,000-square-foot museum opened as the largest museum in the world dedicated to African-American history.The Wright, whose exhibits include Underground Railroad documents and letters from Malcolm X and Rosa Parks, also hosted memorial events for Parks and the "Queen of Soul," Aretha Franklin, who lay in state in the museum's rotunda in 2005 and 2018, respectively. Notably, The Wright is the current home of The National Museum of the Tuskegee Airmen The Wright also produces one of the largest festivals dedicated to celebrating the food, fashion, music, and dance cultures of the diaspora – African World Festival.

The Scarab Club (commonly referred to as Historic Scarab Club of Detroit) is an artists' club, gallery, and studio in the Cultural Center Historic District of Detroit, Michigan, located at 217 Farnsworth Street, near the Detroit Institute of Arts and the Detroit Science Center. It was designated a Michigan State Historic Site in 1974 and listed on the National Register of Historic Places in 1979.

Warren Avenue is a QLine streetcar station in Detroit, Michigan. The station opened for service on May 12, 2017, and is located in Midtown Detroit. The station services the Detroit Medical Center, the Cultural Center neighborhood, and Wayne State University.

The Detroit Institute of Arts (DIA), located in Midtown Detroit, Michigan, has one of the largest and most significant art collections in the United States. With over 100 galleries, it covers 658,000 square feet (61,100 m2) with a major renovation and expansion project completed in 2007 that added 58,000 square feet (5,400 m2). The DIA collection is regarded as among the top six museums in the United States with an encyclopedic collection which spans the globe from ancient Egyptian and European works to contemporary art. Its art collection is valued in billions of dollars, up to $8.1 billion USD according to a 2014 appraisal. The DIA campus is located in Detroit's Cultural Center Historic District, about 2 miles (3.2 km) north of the downtown area, across from the Detroit Public Library near Wayne State University. The museum building is highly regarded by architects. The original building, designed by Paul Philippe Cret, is flanked by north and south wings with the white marble as the main exterior material for the entire structure. The campus is part of the city's Cultural Center Historic District listed in the National Register of Historic Places. The museum's first painting was donated in 1883 and its collection consists of over 65,000 works. With about 677,500 visitors annually for 2015, the DIA is among the most visited art museums in the world. The Detroit Institute of Arts hosts major art exhibitions; it contains a 1,150-seat theatre designed by architect C. Howard Crane, a 380-seat hall for recitals and lectures, an art reference library, and a conservation services laboratory.In 2023, readers of USA Today voted the Detroit Institute of Arts the No. 1 art museum in the United States.

The Cathedral Church of St. Paul is the cathedral church of the Episcopal Diocese of Michigan. In 1824 its congregation formed as the first Episcopal and first Protestant church in the Michigan Territory. Designed by architect Ralph Adams Cram and constructed in 1907, this building is located at 4800 Woodward Avenue in Midtown Detroit, Michigan, adjacent to the campus of Wayne State University. It was listed on the National Register of Historic Places in 1982.

The Detroit Festival of the Arts was a three-day arts festival in Detroit, Michigan, held on the second weekend of June. First held in 1986, the Festival featured free musical performances, art showings, activities for children, and local food. It was located in Detroit's cultural center, spanning the Detroit Institute of Arts, the main branch of the Detroit Public Library, and the main Wayne State University campus. A giant sand sculpture had been a fixture of the event since 2004. The theme of the sand sculpture was selected by the sponsors and not by the artists. Official sponsors for the 2007 Festival included DaimlerChrysler, Macy's and the Metro Times. In 2009, the University Cultural Center Association and Wayne State University produced a new event called "Midsummer Nights in Midtown," which took place every Thursday, Friday, and Saturday in the month of June that year.

Detroit Conservatory of Music was a music school in Detroit, Michigan. It was considered one of the leading institutions of music in the United States. It was founded in 1874 by J. H. Hahn and opened a normal school training department in 1889.It was located at 5035 Woodward Avenue. In 1909 the Detroit Conservatory Orchestra was organized at the school.Chapters of Mu Phi Epsilon, Sigma Alpha Iota, and Phi Mu Alpha Sinfonia existed at the school. The school featured on postcards. The Detroit Historical Society has a collection of documents from the school. The Detroit Public Library has a photograph of a woman playing violin at the school.

The First Congregational Church is located at 33 East Forest Avenue (on the corner of Forest and Woodward Avenue) in Midtown Detroit, Michigan. It was designated a Michigan State Historic Site in 1974 and listed on the National Register of Historic Places in 1979.

The Samuel L. Smith House is located at 5035 Woodward Avenue in Midtown Detroit, Michigan. It was also known as the Schools Annex. It was listed on the National Register of Historic Places in 1986.

The Maccabees Building (sometimes called Wayne Tower) is a historic building located at 5057 Woodward Avenue in Midtown Detroit, Michigan. It was listed on the National Register of Historic Places in 1983, and is currently owned by Wayne State University.

The George W. Loomer House is a private residence located at 71 West Hancock Street in Midtown Detroit, Michigan. It was listed on the National Register of Historic Places in 1994.

Pensole Lewis College of Business and Design is a private, historically black college in Detroit, Michigan. It was also the first and only historically black college in Michigan. Founded in 1928 as the Lewis College of Business by Violet T. Lewis, it specialized in business-related topics. The school originally closed in 2015 after losing its accreditation. However, the school became the first HBCU to reopen, rebranding as Pensole Lewis College of Business and Design in 2021 through the efforts of D'Wayne Edwards, founder of the Pensole Footwear Design Academy, with an emphasis on design in addition to business. The school is operating in a partnership with the College for Creative Studies while it works to obtain a new accreditation, campus, and legal & legislative approval to reopen.The school was the founding location of Gamma Phi Delta sorority, Eta Phi Beta sorority, and Tau Gamma Delta sorority.