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Case Western Reserve School of Medicine (CWRU SOM, CaseMed) is the medical school of Case Western Reserve University, a private research university in Cleveland, Ohio. It is the largest biomedical research center in Ohio. CWRU SOM is primarily affiliated with the Cleveland Clinic, ranked the world’s second-best hospital in 2023. It is also affiliated with University Hospitals Cleveland Medical Center.

The Frances Payne Bolton School of Nursing is the nursing school of Case Western Reserve University in Cleveland, OH. The school is named in honor of Frances Payne Bolton, a former congresswoman from Cleveland's 22nd District.

Case Comprehensive Cancer Center (CCCC) is an NCI-designated Cancer Center in Cleveland, Ohio affiliated with Case Western Reserve University. It was founded in 1987.CCCC employs over 370 faculty members. It is a collaborative organization with the Cleveland Clinic Taussig Cancer Institute and University Hospitals Seidman Cancer Center.Case is organized into six research programs receiving NIH funding. In total, the center has received over $130 million in research funding.

Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established after Western Reserve University—which was founded in 1826 and named for its location in the Connecticut Western Reserve—and Case Institute of Technology—which was founded in 1880 through the endowment of Leonard Case Jr.—formally federated in 1967. Case Western Reserve University comprises eight schools that offer more than 100 undergraduate programs and about 160 graduate and professional options across fields in STEM, medicine, arts, and the humanities. Notably, the Departments of Biomedical Engineering and Biochemistry, administered by the Case Western Reserve University School of Medicine, were respectively ranked 7th and 14th nationally for research activities and expenditures.In 2023, the university enrolled 12,266 students (6,186 undergraduate plus 6,080 graduate and professional) from all 50 states and 102 countries and employed more than 1,110 full-time faculty members. The university's athletic teams, Case Western Reserve Spartans, play in NCAA Division III as a founding member of the University Athletic Association. The Spartans compete in 10 men's and 9 women's varsity sports. Case Western Reserve University is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". According to the National Science Foundation, in 2019 the university had research and development (R&D) expenditures of $439 million, ranking it 20th among private institutions and 58th in the nation.Seventeen Nobel laureates are numbered among Case Western Reserve faculty or alumni, or one of its predecessors. The Michelson–Morley experiment disproving the existence of the "luminiferous aether" was conducted at Case Western in 1887, and Albert A. Michelson became the first American to win the Nobel Prize in science.

Adelbert Hall is an administration building at Case Western Reserve University in Cleveland, Ohio and a registered historic building, listed in the National Register on 1973-10-30.

The Case School of Engineering is the engineering school of Case Western Reserve University, a private research university in Cleveland, Ohio. It traces its roots to the 1880 founding of the Case School of Applied Science. The school was endowed by Leonard Case, Jr. in 1877 and became the Case Institute of Technology in 1947 until merging with Western Reserve University in 1967. It was officially named the Case School of Engineering in 1992.

University Hospitals Cleveland Medical Center (UH Cleveland Medical Center) is a large not-for-profit academic medical complex in Cleveland, Ohio, United States. University Hospitals Cleveland Medical Center is an affiliate hospital of Case Western Reserve University.UH Cleveland Medical Center is the main campus of the University Hospitals Health System. With 150 locations throughout the Cleveland metropolitan area, the University Hospitals Health System encompasses hospitals, outpatient centers, and primary care physicians. UH Cleveland Medical Center is home to world-class clinical and research centers, including cancer care, pediatrics, women's health, orthopedics, spine, radiology, radiation oncology, neurosurgery, neuroscience, psychiatry, cardiology, cardiovascular surgery, organ transplantation, and human genetics.

The Case School of Dental Medicine (CSDM) is a graduate school of Case Western Reserve University. It is an American dental school located in Cleveland, Ohio. The Case School of Dental Medicine is a clinically oriented dental school. It has been ranked consistently high with its affiliated medical school. Admission to Case Dental School has an acceptance rate of 2.1%. Over 3700 applications for admission are received every year, and 300 applicants are interviewed for the limited 75 positions. The most recently admitted class had a mean undergraduate GPA of 3.61 and a mean DAT of 20 (~90th percentile).In addition to the DMD (Doctor of Dental Medicine) degree, Case offers five specialty training programs: The residency program in Oral and Maxillofacial Surgery is a 5-year dual degree (MD-DMD) program that is joint with the Case School of Medicine. The residents receive an MD (Doctor of Medicine) degree at the end of their residency years along with a certificate in Oral and Maxillofacial Surgery. Endodontics, Periodontics, Orthodontics, and Pediatrics are master's degree programs (M.S.D.) with a certificate granted upon completion of the degree requirements.

Michelson-Morley Memorial Fountain, also known as the Michelson-Morley Monument and commonly called the "lipstick fountain," is located on the campus of Case Western Reserve University in the University Circle neighborhood of Cleveland, Ohio. It was designed by William Behnke and built in 1973 in commemoration of the world-famous Michelson–Morley experiment.

The Dittrick Museum of Medical History is part of the Dittrick Medical History Center of the College of Arts and Sciences of Case Western Reserve University, Cleveland, Ohio. The Dittrick Medical History Center is dedicated to the study of the history of medicine through a collection of rare books, museum artifacts, archives, and images. The museum was established in 1898 by the Cleveland Medical Library Association and today functions as an interdisciplinary study center. It is housed in the Allen Memorial Medical Library on the campus of Case Western Reserve University in Cleveland, Ohio's University Circle.

Allen Memorial Medical Library is located along Euclid Avenue on the campus of Case Western Reserve University in Cleveland, Ohio. Completed in 1926, the building was named in honor of Dudley P. Allen. Designed by the Cleveland firm of Walker and Weeks in a classical revival style, it was constructed with Indiana limestone on a pink Georgia marble base. It was listed in the National Register of Historic Places on 1982-11-30 and is a Cleveland Landmark. Along with serving as a library, the erection's 450 seat auditorium serves as classroom for students of Case Western Reserve University.In addition to housing a portion of the Cleveland Health Sciences Library (CHSL), it is also home of the Dittrick Museum of Medical History. The building is managed by the Cleveland Medical Library Association (CMLA) in a partnership with Case Western Reserve University.

Mather House, formally named Flora Mather House, is a college building named for Flora Stone Mather at Case Western Reserve University in Cleveland, Ohio. It was built as a dormitory for the Flora Stone Mather College for Women of Western Reserve University, and currently houses classrooms and offices for the university's departments of art history, classics, history, and political science.It was built during 1913–1915. It was designed by architect Abram Garfield and was built by contractor Roderick D. Grant. The building faces Euclid Avenue, sitting between the Church of the Covenant and Thwing Hall. It is within the Flora Stone Mather College Historic District, but is not counted among its contributing buildings. It should not be confused with the Mather House that formerly stood nearby at 11100 Euclid Avenue, on the University Hospitals of Cleveland main campus. That building, originally a dormitory for nursing students and later occupied by clinics, was one of four structures demolished in 2007 for the construction of the Center for Emergency Medicine and a parking garage, part of the hospital system's Vision 2010 plan.