James Park House

St. John's Cathedral located at 413 Cumberland Avenue in Knoxville, Tennessee, is the cathedral church of the Episcopal Diocese of East Tennessee.

The United States Post Office and Courthouse, commonly called the Knoxville Post Office, is a state building located at 501 Main Street in Knoxville, Tennessee, United States. Constructed in 1934 for use as a post office and federal courthouse, the building contains numerous Art Deco and Moderne elements, and is clad in Tennessee marble. While the building is still used as a branch post office, the court section is now used by the state courts. The building is listed on the National Register of Historic Places for its architecture and political significance.

The Tennessee Theatre is a movie palace in downtown Knoxville, Tennessee. The theater was built in 1928 in the 1908 Burwell Building, considered Knoxville's first skyscraper. The theater and Burwell Building were added to the National Register of Historic Places in 1982, and the theater was extensively restored in the early 2000s. The Tennessee Theatre currently focuses on hosting performing arts events and classic films, and is home to the Knoxville Opera and the Knoxville Symphony Orchestra. The theater is managed by AC Entertainment.

The Lawson McGhee Library is the main library of Knox County Public Library in Knoxville, Tennessee. It is located at 500 West Church Avenue in downtown Knoxville. It is currently the oldest, continuously operating public library in Tennessee.

First Baptist Church is a historic church located in Knoxville, Tennessee. It is on the National Register of Historic Places. The congregation was organized in 1843 by James and John Moses. After its first baptismal service in nearby First Creek, the church had 46 members, including 20 African-Americans. The church organized its first Sunday School in 1845. The first building was constructed on Gay Street in 1844. The second building was built at the same location in 1887. The third (and present) building was completed in 1923 at the Main Street location, three years after Dr. Frederick Fernando Brown became pastor. This architecturally-significant structure, noteworthy for its Neoclassical design and octagonal sanctuary, was designed by Dougherty & Gardner of Nashville, Tennessee, and is modeled on St Martin-in-the-Fields of London. The exterior of the church sanctuary is sheathed in marble, although the adjoining education space is brick. The congregation is moderate, and is member of the Cooperative Baptist Fellowship, a mainline denomination in the South.

The General Building, also called the Tennessee General Building or the First Bank Building, is an office high rise located in downtown Knoxville, Tennessee. Constructed in 1925, the 14-story building is the only high rise designed by Charles I. Barber, and has over the years housed the offices of dozens of banks, physicians, and various financial and architectural firms. The Lexington, Tennessee-based First Bank is the current anchor tenant. In 1988, the General Building was listed on the National Register of Historic Places for its architecture and its role in Knoxville's commercial history.

The Medical Arts Building is an office high-rise located at 603 Main Street in Knoxville, Tennessee, United States. Completed in 1931, the 10-story structure originally provided office space for physicians and dentists, and at the time was considered the "best equipped" medical building in the South. The building has been listed on the National Register of Historic Places as one of the region's best examples of a Gothic Revival-style office building. It has recently been renovated into mixed-use, principally residential use.

The United States District Court for the Eastern District of Tennessee (in case citations, E.D. Tenn.) is the federal court in the Sixth Circuit whose jurisdiction covers most of East Tennessee and a portion of Middle Tennessee. The court has jurisdiction over 41 counties with 4 divisions. Based in Knoxville, Tennessee, it maintains branch facilities in Chattanooga, Tennessee; Greeneville, Tennessee; and Winchester, Tennessee. The Southern Division, based in Chattanooga, Tennessee, serves Bledsoe, Bradley, Hamilton, Marion, McMinn, Meigs, Polk, Rhea and Sequatchie counties. The Northeastern Division, based in Greeneville, Tennessee, serves Carter, Cocke, Greene, Hamblen, Hancock, Hawkins, Johnson, Sullivan, Unicoi and Washington counties. The Northern Division, based in Knoxville, Tennessee, serves Anderson, Blount, Campbell, Claiborne, Grainger, Jefferson, Knox, Loudon, Monroe, Morgan, Roane, Scott, Sevier and Union counties. The Winchester Division serves Bedford, Coffee, Franklin, Grundy, Lincoln, Moore, Warren and Van Buren counties.The United States Attorney for the Eastern District of Tennessee represents the United States in civil and criminal litigation in the court. Since January 5, 2021, the United States attorney has been Francis M. Hamilton III, first as interim United States attorney appointed by United States Attorney General Merrick Garland, until appointed full United States attorney, on April 25, 2022, by the District Court itself, while still waiting for a Presidential appointee to be confirmed by the US Senate.The court was established by the Judiciary Act of 1801 ("Midnight Judges" Act) wherein Congress created a new Sixth Circuit with two districts in Tennessee. Since 1797, the state had been organized by Congress into one judicial district with one judge, John McNairy. Tennessee – along with Kentucky, Ohio, and Michigan – is located within the area covered by United States Court of Appeals for the Sixth Circuit, and appeals are taken to that court (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit).

The Knox County Courthouse is a historic building located at 300 Main Street in Knoxville, Tennessee, United States. Built in 1886, it served as Knox County's courthouse until the completion of the City-County Building in 1980, and continues to house offices for several county departments. John Sevier, Tennessee's first governor, is buried on the courthouse lawn. The courthouse is listed on the National Register of Historic Places for its architecture and its role in the county's political history.

The Old Customs House, also called the Old Post Office, is a historic building located at the corner of Clinch Avenue and Market Street in Knoxville, Tennessee, United States. Completed in 1874, it was the city's first federal building. It housed the federal courts, excise offices and post office until 1933. From 1936 to 1976, it was used by the Tennessee Valley Authority for offices. Expanded in 2004, the building is home to the East Tennessee History Center, which includes the Lawson McGhee Library's Calvin M. McClung Historical Collection, the Knox County Archives, and the East Tennessee Historical Society's headquarters and museum. The building is listed on the National Register of Historic Places for its architectural significance.

The Bijou Theatre is a theater located in Knoxville, Tennessee, United States. Built in 1909 as an addition to the Lamar House Hotel, the theater has at various times served as performance venue for traditional theatre, vaudeville, a second-run moviehouse, a commencement stage for the city's African-American high school, and a pornographic movie theater. The Lamar House Hotel, in which the theater was constructed, was originally built in 1817, and modified in the 1850s. The building and theater were added to the National Register of Historic Places in 1975.The Lamar House Hotel was built by Irish immigrant Thomas Humes (1767–1816) and his descendants, and quickly developed into a gathering place for Knoxville's wealthy. In 1819, Andrew Jackson became the first of five presidents to lodge at the hotel, and in the early 1850s, local businessmen purchased and expanded the building into a lavish 75-room complex. During the Civil War, the Union Army used the hotel as a hospital for its war wounded, among them General William P. Sanders, who died at the hotel in 1863. Following the war, the hotel became the center of Knoxville's Gilded Age extravagance, hosting lavish masquerade balls for the city's elite.In 1909, the rear wing of the building was replaced by the Bijou Theatre structure, entered through a new lobby cut through the hotel building from Gay Street. The theater opened on March 8, 1909, and over the next four decades would host performers such as the Marx Brothers, Dizzy Gillespie, John Philip Sousa, the Ballets Russes, Ethel Barrymore, Alfred Lunt and Lynn Fontanne, John Cullum, and Houdini. After a period of decline in the 1960s and early 1970s, local preservationists purchased the building and renovated the theater.

Church Street United Methodist Church is a United Methodist church located on Henley Street in downtown Knoxville, Tennessee. The church building is considered a Knoxville landmark and is listed on the National Register of Historic Places.