Saco Transportation Center

The Jacobs Houses and Store are a collection of three Federal-period historic buildings at 9-17 Elm Street in Saco, Maine. Built between 1820 and 1826, there are two similar wood-frame houses and a large brick commercial building, all associated with the Jacobs family, local businessmen. The buildings were listed as a group on the National Register of Historic Places in 1982.

The Former Saco Central Fire Station is a historic fire station at 14 Thornton Avenue in Saco, Maine. Built in 1939 with funding from the Public Works Administration, it was the city's first modern firehouse, designed to house motorized (rather than horse-drawn) equipment, and outfitted with the latest technology. The building was listed on the National Register of Historic Places in 2013. The building housed the fire department until 2011, and has since been converted into a mixed-use residential and commercial property.

The Dudley Block is a historic mixed-use commercial and residential building in at 28-34 Water Street in downtown Biddeford, Maine. Built in 1848, it is one of the older buildings in the downtown area, and is a fine example of Greek Revival commercial architecture. It was listed on the National Register of Historic Places in 1982, and was included in the Biddeford Main Street Historic District in 2009.

Saco City Hall is located at 300 Main Street in downtown Saco, Maine. It is a transitional Greek Revival-Italianate brick building, designed by Thomas Hill and built in 1855. It was listed on the National Register of Historic Places in 1979.

The A. B. Seavey House is a historic house at 90 Temple Street in Saco, Maine. Built in 1890, it is one of the city's finest examples of Queen Anne architecture. It was listed on the National Register of Historic Places in 1978.

St. Andre's Parish is a former parish of the Roman Catholic Diocese of Portland, located on Bacon and Sullivan Streets in Biddeford, Maine, USA. The parish was founded in 1860 to serve the city's large French-Canadian and French-American communities. On July 1, 2008, St. Andres was merged into the newly formed Good Shepherd Parish. The parish complex of four buildings, including the church, rectory, convent and school, was listed on the National Register of Historic Places in 2015, at which time most of it stood vacant.

The Biddeford–Saco Mills Historic District encompasses the historic mill complex that flanks both sides of the Saco River in Biddeford and Saco, Maine. It covers 38 acres (15 ha) of property adjacent to both cities' downtown areas which has seen industrial uses since the 18th century, and presently contains a collection of well-preserved 19th and early-20th century industrial buildings. The district was added to the National Register of Historic Places in 2008. Many of the buildings in the district have been rehabilitated and repurposed for other uses, including residential, commercial, and industrial.

The Saco Historic District encompasses the historic commercial and residential centers of Saco, Maine. Covering more than 100 acres (40 ha) of central Saco, it includes houses from the 18th through 20th centuries, and the main business district along Main Street. It was added to the National Register of Historic Places in 1998.

Biddeford Main Street Historic District is an historic district in downtown Biddeford, Maine, USA. It encompasses the heart of the city's civic and commercial business district, extending along Main and Water Streets between Pike and Elm Streets, extending for short distances along several side streets. It is noted for its collection of late 19th and early 20th century commercial brick and masonry architecture. The district was added to the National Register of Historic Places in 2009.

On July 13, 2026, Johan Sebastián Durán Guerrero, a 25-year-old Colombian immigrant to the United States, was shot and killed by David Brouillette, a United States Immigration and Customs Enforcement (ICE) officer during a traffic stop in Biddeford, Maine, United States. Durán Guerrero's car was rammed by an ICE vehicle while he circled an intersection incapacitated after his car was shot at five times; he was struck in the head and pronounced dead at the scene. ICE agents were executing a search warrant, though Durán Guerrero was not the target of the warrant. The incident occurred six days after the killing of Lorenzo Salgado Araujo in Houston, Texas, who was shot by ICE during another traffic stop, and it prompted ICE to suspend using traffic stops to carry out operations; President Donald Trump overturned the suspension a day after it was ordered. The Department of Homeland Security (DHS) and ICE defended the officer who opened fire, saying he was "fearing for public safety" when Durán Guerrero tried to flee. Members of Brouillette's family conducted several interviews with news outlets, saying he had a history of mental health issues, and alleged a history of domestic violence. Allegations of domestic abuse were reflected in family court records. Durán Guerrero's killing sparked several local protests in Biddeford and throughout Maine, and several politicians called on ICE to reform their tactics.

The Old Post Office is a historic former post office building at 35 Washington Street in Biddeford, Maine. Built in 1914, it is a fine local example of Classical Revival architecture, and a prototype for post offices built in the following decades. The property was listed on the National Register of Historic Places in 1973. It now houses commercial offices.

Biddeford City Theater is a year-round near 500-seat, restored Victorian opera house at 205 Main Street in Biddeford, Maine, United States. Biddeford City Theater is a non-profit, volunteer-driven, organization that produces and hosts plays, musicals, concerts, movies, music, comedy, and other artistic performances with patrons from all over New England. The mission of City Theater Associates is to foster an appreciation for the performing arts by using creative avenues to increase community involvement. City Theater is part of the Biddeford City Hall complex, designed by Maine architect John Calvin Stevens in 1895. The building is included on the National Register of Historic Places, and is a contributing element to the Biddeford Main Street Historic District.