Biddeford Main Street Historic District

The Biddeford–Saco Mills Historic District encompasses the historic mill complex that flanks both sides of the Saco River in Biddeford and Saco, Maine. It covers 38 acres (15 ha) of property adjacent to both cities' downtown areas which has seen industrial uses since the 18th century, and presently contains a collection of well-preserved 19th and early-20th century industrial buildings. The district was added to the National Register of Historic Places in 2008. Many of the buildings in the district have been rehabilitated and repurposed for other uses, including residential, commercial, and industrial.

The Old Post Office is a historic former post office building at 35 Washington Street in Biddeford, Maine. Built in 1914, it is a fine local example of Classical Revival architecture, and a prototype for post offices built in the following decades. The property was listed on the National Register of Historic Places in 1973. It now houses commercial offices.

Biddeford City Theater is a year-round near 500-seat, restored Victorian opera house at 205 Main Street in Biddeford, Maine, United States. Biddeford City Theater is a non-profit, volunteer-driven, organization that produces and hosts plays, musicals, concerts, movies, music, comedy, and other artistic performances with patrons from all over New England. The mission of City Theater Associates is to foster an appreciation for the performing arts by using creative avenues to increase community involvement. City Theater is part of the Biddeford City Hall complex, designed by Maine architect John Calvin Stevens in 1895. The building is included on the National Register of Historic Places, and is a contributing element to the Biddeford Main Street Historic District.

McArthur Public Library is a public library in Biddeford, Maine. It opened in October 1863 as a department within Biddeford City Hall, and has been in its current location since 1902. It is one of the oldest tax-supported libraries in New England, and the oldest in the state of Maine.

On July 13, 2026, Johan Sebastián Durán Guerrero, a 25-year-old Colombian immigrant to the United States, was shot and killed by David Brouillette, a United States Immigration and Customs Enforcement (ICE) officer during a traffic stop in Biddeford, Maine, United States. Durán Guerrero's car was rammed by an ICE vehicle while he circled an intersection incapacitated after his car was shot at five times; he was struck in the head and pronounced dead at the scene. ICE agents were executing a search warrant, though Durán Guerrero was not the target of the warrant. The incident occurred six days after the killing of Lorenzo Salgado Araujo in Houston, Texas, who was shot by ICE during another traffic stop, and it prompted ICE to suspend using traffic stops to carry out operations; President Donald Trump overturned the suspension a day after it was ordered. The Department of Homeland Security (DHS) and ICE defended the officer who opened fire, saying he was "fearing for public safety" when Durán Guerrero tried to flee. Members of Brouillette's family conducted several interviews with news outlets, saying he had a history of mental health issues, and alleged a history of domestic violence. Allegations of domestic abuse were reflected in family court records. Durán Guerrero's killing sparked several local protests in Biddeford and throughout Maine, and several politicians called on ICE to reform their tactics.

St. Joseph's School is a historic former school building on Birch Street in Biddeford, Maine. Built in 1887, it was one of the first large masonry schools to be built in the state, and became a focal point for the migration of French Canadians into the state. It was listed on the National Register of Historic Places in 1983. It has been converted to residential use.

The Emery School is an historic former school building at 116 Hill Street in Biddeford, Maine. Built in 1912-13 to a design by Miller & Mayo of Portland, it is historically significant for its role the city's education, and architecturally as a fine example of a "modern" elementary school building of the period. It was listed on the National Register of Historic Places on November 18, 2011. The building has been converted to residential housing units.

The Dudley Block is a historic mixed-use commercial and residential building in at 28-34 Water Street in downtown Biddeford, Maine. Built in 1848, it is one of the older buildings in the downtown area, and is a fine example of Greek Revival commercial architecture. It was listed on the National Register of Historic Places in 1982, and was included in the Biddeford Main Street Historic District in 2009.

Saint Joseph's Church is one of the 5 churches of Good Shepherd Parish located at 178 Elm Street in Biddeford, Maine, and is the tallest building in Maine.

St. Andre's Parish is a former parish of the Roman Catholic Diocese of Portland, located on Bacon and Sullivan Streets in Biddeford, Maine, USA. The parish was founded in 1860 to serve the city's large French-Canadian and French-American communities. On July 1, 2008, St. Andres was merged into the newly formed Good Shepherd Parish. The parish complex of four buildings, including the church, rectory, convent and school, was listed on the National Register of Historic Places in 2015, at which time most of it stood vacant.

Saco Transportation Center, also referred to as Saco or Saco–Biddeford in some timetables, is a passenger transportation station in Saco, Maine, served by Amtrak, the national railroad passenger system, and other transportation providers. On average, about 110 passengers daily board or alight Amtrak's Downeaster service at the station, making it the third-busiest stop in Maine. The station is located next to the Pan Am Railways mainline, formerly the Western Route mainline of the Boston & Maine Railroad. The train platform was constructed in 2001, and the station building was constructed in 2008 and opened in 2009. The station, at 138 Main Street, is owned by the City of Saco. The station is notable for being the first green design train station in the U.S. When it was built, it featured a wind turbine for electricity, geothermal heating and cooling systems, and a roof made from recycled soda bottles; however, the wind turbine, which cost the city about $200,000, did not produce the expected amount of electricity, and was shut down in 2006 after safety concerns. It was removed in November 2018.

The Jacobs Houses and Store are a collection of three Federal-period historic buildings at 9-17 Elm Street in Saco, Maine. Built between 1820 and 1826, there are two similar wood-frame houses and a large brick commercial building, all associated with the Jacobs family, local businessmen. The buildings were listed as a group on the National Register of Historic Places in 1982.