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Slough () is a town in the unitary authority of the same name in Berkshire, England, bordering Greater London. It lies in the Thames Valley, 20 miles (32 km) west of central London and 19 miles (31 km) north-east of Reading, at the intersection of the M4, M40 and M25 motorways. It is part of the historic county of Buckinghamshire. In 2020, the built-up area subdivision had an estimated population of 164,793. In 2011, the district had a population of 140,713.Slough's population is one of the most ethnically diverse in the United Kingdom, attracting people from across the country and the world for labour since the 1920s, which has helped shape it into a major trading centre. In 2017, unemployment stood at 1.4%, one-third the UK average of 4.5%.Slough has the highest concentration of UK HQs of global companies outside London. Slough Trading Estate is the largest industrial estate in single private ownership in Europe, with over 17,000 jobs in 400 businesses. Blackberry, McAfee, Burger King, DHL, Telefonica and Lego have head offices in the town.

Slough Museum is an independent museum in Slough in the English county of Berkshire. It has two exhibition galleries presenting the past, present and future of the town.

Upton is a suburb of Slough, in the Slough district, in the ceremonial county of Berkshire, England. Until the local government reforms of 1974 it was in Buckinghamshire. It was one of the villages that developed into the town.

Slough was, from 1863 to 1974, a local government district in southern Buckinghamshire, England. It became an urban district in 1894 and was incorporated as a municipal borough in 1938. It was abolished in 1974 and now forms part of the borough of Slough in Berkshire.

Slough railway station, in Slough, Berkshire, England, is on the Great Western Main Line, halfway between London Paddington and Reading. It is 18 miles 36 chains (18.45 mi; 29.7 km) down the line from the zero point at Paddington and is situated between Langley to the east and Burnham to the west. The station is just to the north of the town centre, on the north side of the A4. It is served by Great Western Railway, with services to Paddington, Reading, Oxford, and Didcot Parkway; and by the Elizabeth line on local services between Abbey Wood and Reading. It is the terminus for trains from Windsor on the Windsor branch.

Slough is a constituency represented in the House of Commons of the UK Parliament by Tan Dhesi, a member of the Labour Party, since the 2017 UK general election. Slough had previously been represented since 1997 by Fiona Mactaggart, also of the Labour Party, until she stepped down from politics.

Slough bus station is a bus station in Slough, United Kingdom. The bus station is situated adjacent to Slough railway station.

St Ethelbert's Church or Our Lady Immaculate and St Ethelbert's Church is a Roman Catholic parish church in Slough, Berkshire, England. It was built from 1908 to 1910 and designed by Benedict Williamson. It is located on the corner of Wellington Street and William Street in the centre of the town. It is in the Gothic Revival style and is a Grade II listed building.

Saint Laurence's Church is one of three Church of England parish churches in the benefice of Upton-cum-Chalvey, and is the oldest building in the borough of Slough, in Berkshire, England. In the 12th century the wooden parish church of Upton was replaced with a flint building. The tower and outside walls of the Norman building form part of the present church. Several of the walls are built of puddingstone. Two other Norman features survive: the ancient baptismal font and a piscina. In the English Reformation many of the ancient decorations were mutilated. A 13th-century Italian allegorical image of the Trinity – God Father, Son and Holy Spirit – survived and was reassembled in the restoration of the church.

St Mary's Parish Church is a red brick gothic style Church of England parish church in the parish of Upton cum Chalvey in the borough of Slough and the county of Berkshire in England. Built between 1876–8 to a design by John Oldrid Scott and partly funded through a personal donation by Queen Victoria, it was again enlarged in 1911–1913, and is protected as a grade II* listed building. The grounds contain the grade II listed war memorial by the west door of the church, inscribed with over 300 names of the dead from Slough in the First and Second World Wars. The walls and gates of the church yard are also protected grade II listed features. The church is located centrally in the parish, serving the Slough town centre. The church is linked to two schools in the area, Saint Mary's Church of England Primary School, in Upton, and Slough and Eton Church of England Secondary School, in Chalvey. The building regularly plays host to musical concerts, often including accompaniment on the organ

The Slough rail accident happened on 16 June 1900 at Slough railway station on the Great Western Main Line when an express train from London Paddington to Falmouth Docks ran through two sets of signals at danger, and collided with a local train heading for Windsor & Eton Central. Five passengers were killed; 35 were seriously injured, and 90 complained of shock or minor injuries Significant consequences of the accident were the adoption of improved vacuum braking systems on locomotives and passenger rolling stock, and the introduction of Automatic Train Control (ATC) in 1908.

The Heart of Slough project is a £400 million plan to redevelop the town centre in Slough, Berkshire. Begun in 2009, it aims to create a "cultural quarter" for the creative media, information and communications industries in the town. Part of the renovation has been funded by a middle-eastern business.