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HECToR

AC with 0 elementsComputer science institutes in the United KingdomCrayEngineering and Physical Sciences Research CouncilNatural Environment Research Council
Research institutes in EdinburghSupercomputer sitesUniversity of EdinburghX86 supercomputers

HECToR (High End Computing Terascale Resource) was a British academic national supercomputer service funded by EPSRC, Natural Environment Research Council (NERC) and BBSRC for the UK academic community. The HECToR service was run by partners including EPCC, Science and Technology Facilities Council (STFC) and Numerical Algorithms Group (NAG).The supercomputer itself (currently a Cray XE6) was located at the University of Edinburgh in Scotland. The first phase came on line in October 2007, and, by the time it was decommissioned, it had been upgraded to Phase 3 configuration, with a peak performance of over 800 teraflops. Its successor is called ARCHER.

Excerpt from the Wikipedia article HECToR (License: CC BY-SA 3.0, Authors).

HECToR
Peter Guthrie Tait Road, City of Edinburgh Blackford

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N 55.9217 ° E -3.174 °
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James Clerk Maxwell Building

Peter Guthrie Tait Road
EH9 3FD City of Edinburgh, Blackford
Scotland, United Kingdom
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SIRCAMS

The Scottish Instrumentation and Research Centre for Advanced Mass Spectrometry (SIRCAMS) is a facility for ultra-high resolution mass spectrometry of biomolecules. SIRCAMS is based in the University of Edinburgh School of Chemistry.Much of the research activity is focused toward the development and application of mass spectrometry for the analysis of intact peptides, proteins, protein–protein, and protein–RNA/DNA complexes. Recent studies have included: identification of platination sites in peptides (bombesin, substance P, angiotensin, bradykinin) using Infrared multiphoton dissociation (IRMPD), Collision-induced dissociation (CID) and Electron-capture dissociation (ECD), accurate mass measurements on intact proteins (YdaE 6.5kDa, ubiquitin 8.6kDa, trypsinogen 24kDa, carbonic anhydrase 28kDa, beSOD 31kDa, FbpA 33kDa, BSA 66kDa) under native and denaturing conditions, identification of dynamic post-translational modifications in intact human histones using top-down ECD, top-down identification of proteins from complex mixtures, as well as accurate mass analysis of oligonucleotide DNA strands (40 bp). The capital cost of FTICR instruments operating at field strengths higher than 9.4 T are such that few University institutions worldwide can offer access. SIRCAMS offers user access to a 12T Bruker SolariX FTICR mass spectrometer within the facility. By taking advantage of the research expertise that has been developed by staff within the facility, users have access to techniques for accurate mass measurement of intact proteins with isotope peak fitting, top-down protein sequencing from complex mixtures (such as biomarker identification) solution and gas-phase HDX for protein conformational studies, mapping of post-translational modifications in peptides and proteins, and identification of DNA modifications.