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The Scottish Instrumentation and Research Centre for Advanced Mass Spectrometry (SIRCAMS) is a facility for ultra-high resolution mass spectrometry of biomolecules. SIRCAMS is based in the University of Edinburgh School of Chemistry.Much of the research activity is focused toward the development and application of mass spectrometry for the analysis of intact peptides, proteins, protein–protein, and protein–RNA/DNA complexes. Recent studies have included: identification of platination sites in peptides (bombesin, substance P, angiotensin, bradykinin) using Infrared multiphoton dissociation (IRMPD), Collision-induced dissociation (CID) and Electron-capture dissociation (ECD), accurate mass measurements on intact proteins (YdaE 6.5kDa, ubiquitin 8.6kDa, trypsinogen 24kDa, carbonic anhydrase 28kDa, beSOD 31kDa, FbpA 33kDa, BSA 66kDa) under native and denaturing conditions, identification of dynamic post-translational modifications in intact human histones using top-down ECD, top-down identification of proteins from complex mixtures, as well as accurate mass analysis of oligonucleotide DNA strands (40 bp). The capital cost of FTICR instruments operating at field strengths higher than 9.4 T are such that few University institutions worldwide can offer access. SIRCAMS offers user access to a 12T Bruker SolariX FTICR mass spectrometer within the facility. By taking advantage of the research expertise that has been developed by staff within the facility, users have access to techniques for accurate mass measurement of intact proteins with isotope peak fitting, top-down protein sequencing from complex mixtures (such as biomarker identification) solution and gas-phase HDX for protein conformational studies, mapping of post-translational modifications in peptides and proteins, and identification of DNA modifications.

The School of Chemistry is a school of the University of Edinburgh, in Scotland. In the 2008 Research Assessment Exercise (RAE) the school was ranked sixth in the UK.

The King's Buildings (colloquially known as KB) is a campus of the University of Edinburgh in Scotland. Located in the suburb of Blackford, the site contains most of the schools within the College of Science and Engineering, excepting only the School of Informatics and part of the School of Geosciences, which are located at the central George Square campus. The campus lies south of West Mains Road, west of Mayfield Road and east of Blackford Hill, about 2 miles (3.2 km) south of George Square. Scotland's Rural College (SRUC) and Biomathematics and Statistics Scotland (BioSS) also have facilities there.

EPCC, formerly the Edinburgh Parallel Computing Centre, is a supercomputing centre based at the University of Edinburgh. Since its foundation in 1990, its stated mission has been to accelerate the effective exploitation of novel computing throughout industry, academia and commerce. The University has supported high performance computing (HPC) services since 1982. As of 2013, through EPCC, it supports the UK's national high-end computing system, ARCHER (Advanced Research Computing High End Resource), and the UK Research Data Facility (UK-RDF).

HECToR (High End Computing Terascale Resource) was a British academic national supercomputer service funded by EPSRC, Natural Environment Research Council (NERC) and BBSRC for the UK academic community. The HECToR service was run by partners including EPCC, Science and Technology Facilities Council (STFC) and Numerical Algorithms Group (NAG).The supercomputer itself (currently a Cray XE6) was located at the University of Edinburgh in Scotland. The first phase came on line in October 2007, and, by the time it was decommissioned, it had been upgraded to Phase 3 configuration, with a peak performance of over 800 teraflops. Its successor is called ARCHER.

The University of Edinburgh School of Physics and Astronomy is the physics department of the University of Edinburgh. The School was formed in 1993 by a merger of the Department of Physics and the Department of Astronomy, both at the University of Edinburgh. The Department of Physics itself was a merger between the Department of Natural Philosophy and the Department of Mathematical Physics in the late 1960s. The School is part of the University's College of Science and Engineering.

The Laboratory for Foundations of Computer Science (LFCS) is a research institute within the School of Informatics at the University of Edinburgh, in Scotland. It was founded in 1987 and is a community of theoretical computer scientists with interests in concurrency, semantics, categories, algebra, types, logic, algorithms, complexity, databases and modelling.

Liberton Tower is a four-storey, square-plan tower house in the Edinburgh suburb of Liberton, on the east side of the Braid Hills.

The Reid Memorial Church is a church in Edinburgh. It is a congregation of the Church of Scotland (in the Presbytery of Edinburgh) and is located in the Blackford area on the south side of the city.

Blackford is an area in the south of Edinburgh, the capital city of Scotland. It is located near Morningside, and The Grange. Blackford Hill dominates the view to the south. The majority of the Blackford is now housing, mostly dating from the Victorian or Edwardian eras. The local parish church of the Church of Scotland is the Reid Memorial Church, which was opened in 1935.

The Royal Observatory, Edinburgh (ROE) is an astronomical institution located on Blackford Hill in Edinburgh. The site is owned by the Science and Technology Facilities Council (STFC). The ROE comprises the UK Astronomy Technology Centre (UK ATC) of STFC, the Institute for Astronomy of the School of Physics and Astronomy of the University of Edinburgh, and the ROE Visitor Centre. The observatory carries out astronomical research and university teaching; design, project management, and construction of instruments and telescopes for astronomical observatories; and teacher training in astronomy and outreach to the public. The ROE Library includes the Crawford Collection of books and manuscripts gifted in 1888 by James Ludovic Lindsay, 26th Earl of Crawford. Before it moved to the present site in 1896, the Royal Observatory was located on Calton Hill, close to the centre of Edinburgh, at what is now known as the City Observatory.

The UK Astronomy Technology Centre (UK ATC) is based at the Royal Observatory in Edinburgh, Scotland, and is part of the Science and Technology Facilities Council. The UK ATC designs, builds, develops, tests and manages major instrumentation projects in support of UK and international Astronomy. It has design offices, workshops and test facilities for both ground- and space-based instruments, including a suite of test labs capable of handling the largest current and projected instruments.The UK ATC was formed in 1998 in Edinburgh from the technology departments of the Royal Observatory, Edinburgh (ROE), and the Royal Greenwich Observatory, Cambridge (RGO). Its initial "customers" were the then new Gemini Observatory, the former ROE observatories in Hawaii (the James Clerk Maxwell Telescope (JCMT) and the United Kingdom Infrared Telescope (UKIRT)), and a former RGO observatory, the Isaac Newton Group on La Palma, Canary Islands. More recently, collaboration with the European Southern Observatory (ESO) and for the James Webb Space Telescope (JWST) have gained importance. Major projects and collaborations include: Several first-generation instruments for the Gemini Observatory. A mid-infrared spectrometer for the UKIRT and the Gemini Observatory. Data acquisition and reduction software for the UKIRT and the JCMT. The Wide Field Infrared Camera for the UKIRT. The Spectral and Photometric Imaging Receiver of the Herschel Space Observatory. The Visible and Infrared Survey Telescope for UK universities and ESO. A high-sensitivity, wide-field, sub-millimetre camera for the JCMT (SCUBA2). The MIRI (Mid-Infrared Instrument) for the JWST. Observing tool software for the Atacama Large Millimeter Array. Design studies for ESO's European Extremely Large Telescope. An infrared K-band multi-object spectrometer for ESO's Very Large Telescope. The European Union funded Optical Infrared Coordination Network for Astronomy (OPTICON).Following increased government emphasis on knowledge transfer and declining funds for the Science and Technology Facilities Council the UK ATC is increasingly working on projects with astronomical institutions beyond the UK and the EU, with institutions dedicated to science and technology other than astronomy, and with technology-related businesses.