Trinidad Regional Virus Laboratory

Port of Spain, officially the City of Port of Spain (also stylized Port-of-Spain), is the capital of Trinidad and Tobago and the third largest municipality, after Chaguanas and San Fernando. The city has a municipal population of 49,031 (2022 census), an urban population of 545,045 (2023 estimate) and a transient daily population of 250,000. It is located on the Gulf of Paria, on the northwest coast of the island of Trinidad and is part of a larger conurbation stretching from Chaguaramas in the west to Arima in the east with an estimated population of 600,000.The city serves primarily as a retail and administrative centre and it has been the capital of the island since 1757. It is also an important financial services centre for the Caribbean and is home to two of the largest banks in the region. The Piarco International Airport is the main airport on the island, connecting the capital to various major global destinations. Port of Spain was also the de facto capital of the short-lived West Indies Federation, which united the Caribbean. The city is also home to the largest container port on the island and is one of several shipping hubs of the Caribbean, exporting both agricultural products and manufactured goods. Bauxite from Guyana is trans-shipped via facilities at Chaguaramas, about 8 kilometres (5 mi) west of the city. The pre-lenten Carnival is the city's main annual cultural festival and tourist attraction. Today, Port of Spain is a leading city in the Caribbean region. Trinidad and Tobago hosted the Fifth Summit of the Americas in 2009, whose guests included US President Barack Obama and US Secretary of State Hillary Clinton.Port of Spain is also home to the biggest and most successful stock exchange in the Caribbean, the Trinidad and Tobago Stock Exchange (TTSE). The Nicholas Tower, as well as other skyscrapers, are well known throughout the region. These buildings dominate the city's skyline. Some of the tallest skyscrapers in the Caribbean are located in Port of Spain.

Saint James is a district of Port of Spain, Trinidad and Tobago. Port of Spain's last major municipal expansion occurred in 1938, when the St. James district north of Woodbrook and west of St. Clair was incorporated into the city limits. In the late 19th century, Indian indentured labourers on nearby sugar estates established houses here, and St. James gradually became the centre of Port of Spain's Indian population, with many streets named after cities and districts in British India. Western Main Road, the area's major thoroughfare, has long been the city's main nightlife district, sometimes nicknamed "the city that never sleeps". Long Circular Road, which curves north from Western Main Road then east to meet Maraval Road, forms part of the city boundary. Its "circle" encloses Flagstaff Hill, a small rise with the US ambassador's residence at its summit, which lends its name to an area of apartment buildings at its southern foot. South of St. James and near the seashore at Invaders Bay is Mucurapo, a mostly residential district which also contains the city's second-largest cemetery.

The Roman Catholic Metropolitan Archdiocese of Port of Spain (Latin: Archidioecesis Metropolitae Portus Hispaniae) is a metropolitan diocese of the Latin Church of the Roman Catholic Church in the Caribbean. The archdiocese encompasses the entirety of the former Spanish dependency of Trinidad, including the islands of Trinidad and Tobago. The archdiocese is the Metropolitan responsible for the suffragan Dioceses of Bridgetown, Georgetown, Paramaribo and Willemstad, and is a member of the Antilles Episcopal Conference. The diocese of Port of Spain was originally erected as a vicariate apostolic in 1818 and elevated to an archdiocese in April 1830.

The Embassy of the United States in Port of Spain is the diplomatic mission of the United States of America in Trinidad and Tobago. Since the inception of diplomatic ties in 1962, Trinidad and Tobago has become one of the most industrialized nations in the English-speaking Caribbean. The embassy processes about 36,000 visa applications per year.

Queen's Royal College (St.Clair, Trinidad), referred to for short as QRC, or "The College" by alumni, is a secondary school in Trinidad and Tobago. Originally a boarding school and grammar school, the secular college is selective and noted for its German Renaissance architecture, academic performance and alumni representation in sports, politics and science in Trinidad and Tobago and globally.

Queen's Park Savannah (QPS) is a park in Port of Spain, Trinidad and Tobago. Known locally as simply "the Savannah", it is Port of Spain's largest open space. It occupies about 260 acres (110 ha) of level land, and the distance around the perimeter is about 2.2 mi (3.5 km).

The Magnificent Seven is a group of seven mansions located west of the Queen's Park Savannah in northern Port of Spain, Trinidad and Tobago on Maraval Road in the St Clair neighborhood. They were built between 1902 and 1910 on land that was previously used as a government stock farm and are listed as heritage sites at the National Trust of Trinidad and Tobago. Stollmeyer's Castle was the first building in the neighborhood and took several years to complete, as was typical of the Magnificent Seven. The structures were designed in an array of architectural styles including French Colonial, Scottish baronial, Indian Empire, and Moorish Mediterranean styles—often blended with Caribbean architecture. Many have unusual elements, like the chiming clock and lighted clock tower of Queen's Royal College. Stollmeyer's Castle is said to be modeled after a wing of Balmoral Castle. Hayes Court, a French Colonial style building, has contemporary Scottish cast iron elements and traditional Demerara windows. White Hall is made of natural white limestone of Barbados. Some of the structures were made of imported materials, like Italian marble and Scottish cast iron elements. Most were originally built as residences and kept within families for decades. Archbishop's House was built as, and remains, the official residence of the Archbishop of Port of Spain. The Anglican Bishop to Trinidad resided in Hayes Court. Queen's Royal College was built as a secondary school for boys. White Hall was used as the Office of the Prime Minister from 1963 to 2009. White Hall and Stollmeyer's Castle fall under the purview of the Office of the Prime Minister. The two buildings had restoration work so that they could be used by foreign dignitaries visiting Port of Spain. Both buildings were commandeered by the United States Armed Forces during World War II. Most of the Magnificent Seven Houses retain the aesthetics of the original designs. Of the buildings, Milles Fleur is the one most in disrepair due to extended periods where it was not occupied or maintained.

The British Academy is a private, co-ed, primary and secondary school in Port of Spain, Trinidad and Tobago established in 2006. It is certificated by Cambridge Assessment International Education.

The College of Science, Technology and Applied Arts of Trinidad and Tobago (COSTAATT) is a public, multi-campus college in Trinidad and Tobago, established in 2000.

Saint Clair is a business and residential district between the Queen's Park Savannah and the Maraval River in Port of Spain, Trinidad and Tobago. It is home to most of the city's grandest and largest mansions and also home to the Magnificent Seven Houses. Federation Park and Ellerslie Park. St Clair is one of Port of Spain's five police districts.In 1893, St Clair was host to the Inter-Colonial Cup, a three-way cricket match between Trinidad and Tobago (then Trinidad), Barbados, and the-then British Guiana. Only white players were allowed, and that excluded most of the home side's best cricketers.

Bishop Anstey High School (BAHS), also known as Bishop Anstey or St. Hilary's, is a government-assisted all-girls secondary school in Port of Spain, Trinidad and Tobago. It was founded by the Anglican Bishop Arthur Henry Anstey and opened on January 13, 1921. The school is governed by a Board of Management appointed and chaired by the Bishop of Trinidad and Tobago. Its assets are controlled and managed by The Bishop Anstey Association.

The Chinese Ambassador to Trinidad and Tobago is the official representative of the People's Republic of China to the Republic of Trinidad and Tobago.