Concord River

Saints Medical Center, a hospital, has been called "Lowell General - Saints Campus," since 2012 when it became a part of Lowell General Hospital. The campus is located at One Hospital Drive in Lowell, Massachusetts.The hospital was created out of a 1992 merger of two of the three hospitals in the city, St. Joseph's Hospital founded in 1839 and St. John's Hospital founded in 1867. The name changed to "Saints Medical Center" in 2006.In 2010 The hospital was renamed from Saints Memorial Medical Center to Saints Medical Center. On July 1, 2012 Saints merged with Lowell General Hospital. Several Saints satellite facilities have been reconfigured or cut back following the merger. In spring 2023, Saints Medical Centre received a B grading according to hospital safety grades.

The Musketaquid Mills is a historic mill building at 131 Davidson Street in Lowell, Massachusetts. It is the only mill building remaining on the east side of the Concord River, in the city's Belvidere section. The four story brick building was built in stages, beginning in 1909 with the construction of six bays of three stories. Between 1912 and 1925 it underwent two major expansions to reach its present four stories and fourteen bays. The building was used for textile production until 1980, and was used for storage for a time. It has been rehabilitated, and now houses Lowell's welfare services offices.The building was listed on the National Register of Historic Places in 1999.

The Varnum Building was a historic mixed-use commercial and residential building in Lowell, Massachusetts. It was a four-story wood-frame structure with an angled front at the corner of Bridge and Third Streets, topped by a square cupola with bellcast pyramidal roof. It was built in 1882 by Leavitt and Daniel Varnum, who operated an insurance business on the premises, and was one of the oldest commercial buildings on Bridge Street. It was added to the National Register of Historic Places in 1988.The building was heavily damaged in an electrically ignited fire on the morning of February 12, 2010, and was declared a total loss. It was demolished on February 18, 2010.

Completed in 1796, the Pawtucket Canal was originally built as a transportation canal to circumvent the Pawtucket Falls of the Merrimack River in East Chelmsford, Massachusetts. In the early 1820s it became a major component of the Lowell power canal system. with the founding of the textile industry at what became Lowell.The Pawtucket Falls are a mile long series of falls and rapids over which the Merrimack River drops 32 feet. The falls hampered the shipment of inland goods, mostly lumber, to the mouth of the Merrimack and Newburyport, Massachusetts. Newburyport was then one of the largest shipbuilding centers in New England, and a steady supply of wood from New Hampshire was critical to its industry. The original canal was built by wealthy Boston merchants who formed a limited liability corporation called the Proprietors of Locks and Canals, one of the first of its kind in the United States. However, within a decade of its construction the Middlesex Canal was completed, connecting the Merrimack directly with Boston, Massachusetts. Bringing goods directly to Boston was more advantageous for merchants, and the Pawtucket Canal fell out of favor for inland transport. The investors in the Boston Manufacturing Company having successfully built upon Francis Cabot Lowell and Paul Moody's work in building a successfully integrated cotton mill at Waltham, Massachusetts on the Charles River were looking for a site that offered more waterpower and the Pawtucket Falls offered what they needed. In 1821 they bought the Proprietors of Locks and Canals and with it the water rights of the Merrimack River upstream from the Pawtucket Falls. The Pawtucket Canal was deepened to become a power canal, and the first of 5.6 miles of canals in the soon to be named City of Lowell, Massachusetts. The first canal built off the Pawtucket Canal was the Merrimack Canal, which powered the Merrimack Manufacturing Company, thus starting the Lowell experiment, and the first planned industrial city in the United States. The canal is operated today by Boott Hydro, LLC.

The Rex Center was an arena and entertainment center in downtown Lowell, Massachusetts, existing from 1933 to 1960. Entrepreneur and car dealer Charles Dancause created the Rex, which opened in 1933 in a renovated mill building, the old Prescott Division Plant of Mass Cotton Mills. The architect of the conversion was Harry Prescott Graves.Among the entertainments offered at the Rex was dining (the Rex Grille, which also offered floorshows), bars, a dancing ballroom, duckpin bowling (65 lanes), roller skating, pool (30 tables), and Turkish baths. There were five banquet halls; banquets, wedding receptions, and other events were held there. The Rex Center constituted an important part of Lowell social life in the mid 20th century; the Lowell Sun described it as "one of Lowell's landmark spots" and "the sports and dining showplace of Lowell".The Rex Arena in the center seated 1,000 or 2,000 and hosted boxing matches, and also wrestling matches (featuring appearances by Jim Londos, Ed "Strangler" Lewis, The French Angel, Man Mountain Dean, Dropkick Murphy, Bull Curry and many others), particularly after the older Crescent Rink on Hurd Street burned down. Semi-pro basketball games were played there, and the Harlem Globetrotters appeared there.The Rex Center burned down on June 25, 1960. The huge fire raged out of control for several hours, and of the more than 300 firefighters from Lowell and 14 other towns, sixteen were injured. The derelict building was torn down in 1971 and replaced with a parking lot. Wang Laboratories built a training center at the site in 1984, which in 1990 was purchased by Middlesex Community College and is now used as its Lowell campus.

The F. Bradford Morse Federal Building, formerly the United States Post Office is a historic post office at 50 Kearney Square in Lowell, Massachusetts. The building was designed by George Augustine Daidy and was built in 1930. It was added to the National Register of Historic Places in 1986. The building was acquired in 1996 by Middlesex Community College, which renovated the facility for $11 million. It was renamed in honor of local Congressman and statesman F. Bradford Morse on December 8, 2006.Today, the building houses the MCC Lowell campus library, the Honors Center, and art studio and classrooms.It is distinct from 1895 Lowell Post Office, which is also listed on the National Register.

The Washington Square Historic District of Lowell, Massachusetts encompasses a historic subdivision laid out in 1832. The focal point of the subdivision is Kittridge Park, which lies on the eastern side of the district and was an original part of the subdivision plan developed by the Nesmith Brothers. It was the first significant residential subdivision in the city aimed at a wealthier clientele, and was designed by landscape architect Alexander Wadsworth. The district was added to the National Register of Historic Places in 1982, and expanded slightly in 1999.

The Varnum School is a historic former school building in Lowell, Massachusetts. The Greek Revival building was built in 1857, and was the first school built in the city's Centralville section after it was annexed to the city in 1851. The building was altered with a minor addition added in 1886, and a substantial Classical Revival addition was made in 1896. The building was listed on the National Register of Historic Places in 1995. Vacant since the 2000s, it is now owned by a developer, and is slated for conversion to housing units.

The Lowell Historic Preservation District is a historic district created by the legislation establishing Lowell National Historic Park. The district encompasses an area of more than 500 acres (200 ha), including virtually all of the historically significant resources associated with the industrial history of the city of Lowell, Massachusetts. It includes the industrial mill complexes, worker housing areas, central business district, and civic heart of the city, as well as the water power infrastructure that powered the mills.The district was listed on the National Register of Historic Places in 2001.

The Lowell Museum, located in Lowell, Massachusetts, was founded by Moses Kimball in 1840, as an art exhibit hall and entertainment venue.

The Boott Mills in Lowell, Massachusetts were a part of an extensive group of cotton mills, built in 1835 alongside a power canal system in this important cotton town. Its incorporators were Abbott Lawrence, Nathan Appleton, and John Amory Lowell, and is named after Kirk Boott, the first Agent of the Proprietors of Locks & Canals in Lowell. Today, the Boott Mills complex is the most complete remainder of antebellum textile mills built in Lowell. The original Mill No. 6 is managed by the National Park Service unit Lowell National Historical Park and houses the Boott Cotton Mills Museum and the Tsongas Industrial History Center for K-12 educational programs.

The Colburn School is a historic former school building at 136 Lawrence Street in Lowell, Massachusetts, USA. Built in 1848, it is a fine example of institutional Greek Revival architecture, and is one of the city's older surviving school buildings, built during the rapid population growth that followed the city's industrialization. Now converted to apartments, it was listed on the National Register of Historic Places in 1995.