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The F. Bradford Morse Federal Building, formerly the United States Post Office is a historic post office at 50 Kearney Square in Lowell, Massachusetts. The building was designed by George Augustine Daidy and was built in 1930. It was added to the National Register of Historic Places in 1986. The building was acquired in 1996 by Middlesex Community College, which renovated the facility for $11 million. It was renamed in honor of local Congressman and statesman F. Bradford Morse on December 8, 2006.Today, the building houses the MCC Lowell campus library, the Honors Center, and art studio and classrooms.It is distinct from 1895 Lowell Post Office, which is also listed on the National Register.

Completed in 1796, the Pawtucket Canal was originally built as a transportation canal to circumvent the Pawtucket Falls of the Merrimack River in East Chelmsford, Massachusetts. In the early 1820s it became a major component of the Lowell power canal system. with the founding of the textile industry at what became Lowell.The Pawtucket Falls are a mile long series of falls and rapids over which the Merrimack River drops 32 feet. The falls hampered the shipment of inland goods, mostly lumber, to the mouth of the Merrimack and Newburyport, Massachusetts. Newburyport was then one of the largest shipbuilding centers in New England, and a steady supply of wood from New Hampshire was critical to its industry. The original canal was built by wealthy Boston merchants who formed a limited liability corporation called the Proprietors of Locks and Canals, one of the first of its kind in the United States. However, within a decade of its construction the Middlesex Canal was completed, connecting the Merrimack directly with Boston, Massachusetts. Bringing goods directly to Boston was more advantageous for merchants, and the Pawtucket Canal fell out of favor for inland transport. The investors in the Boston Manufacturing Company having successfully built upon Francis Cabot Lowell and Paul Moody's work in building a successfully integrated cotton mill at Waltham, Massachusetts on the Charles River were looking for a site that offered more waterpower and the Pawtucket Falls offered what they needed. In 1821 they bought the Proprietors of Locks and Canals and with it the water rights of the Merrimack River upstream from the Pawtucket Falls. The Pawtucket Canal was deepened to become a power canal, and the first of 5.6 miles of canals in the soon to be named City of Lowell, Massachusetts. The first canal built off the Pawtucket Canal was the Merrimack Canal, which powered the Merrimack Manufacturing Company, thus starting the Lowell experiment, and the first planned industrial city in the United States. The canal is operated today by Boott Hydro, LLC.

The Lowell Museum, located in Lowell, Massachusetts, was founded by Moses Kimball in 1840, as an art exhibit hall and entertainment venue.

The Musketaquid Mills is a historic mill building at 131 Davidson Street in Lowell, Massachusetts. It is the only mill building remaining on the east side of the Concord River, in the city's Belvidere section. The four story brick building was built in stages, beginning in 1909 with the construction of six bays of three stories. Between 1912 and 1925 it underwent two major expansions to reach its present four stories and fourteen bays. The building was used for textile production until 1980, and was used for storage for a time. It has been rehabilitated, and now houses Lowell's welfare services offices.The building was listed on the National Register of Historic Places in 1999.

The Lowell Historic Preservation District is a historic district created by the legislation establishing Lowell National Historic Park. The district encompasses an area of more than 500 acres (200 ha), including virtually all of the historically significant resources associated with the industrial history of the city of Lowell, Massachusetts. It includes the industrial mill complexes, worker housing areas, central business district, and civic heart of the city, as well as the water power infrastructure that powered the mills.The district was listed on the National Register of Historic Places in 2001.

The Boott Mills in Lowell, Massachusetts were a part of an extensive group of cotton mills, built in 1835 alongside a power canal system in this important cotton town. Its incorporators were Abbott Lawrence, Nathan Appleton, and John Amory Lowell, and is named after Kirk Boott, the first Agent of the Proprietors of Locks & Canals in Lowell. Today, the Boott Mills complex is the most complete remainder of antebellum textile mills built in Lowell. The original Mill No. 6 is managed by the National Park Service unit Lowell National Historical Park and houses the Boott Cotton Mills Museum and the Tsongas Industrial History Center for K-12 educational programs.

The Bon Marché was a department store in downtown Lowell, Massachusetts, in business from 1878 to 1976.Frederic Mitchell founded a dry goods store in 1878 under the name "This is Mitchell's". His brother Charles Mitchell operated a shoe store. Both stores were on Merrimack Street. In 1887, Frederick and Charles combined their operation, under the name The Bon Marché.Of the building that became the Bon Marché store, the small righthand section was built around 1874 (before Bon Marché existed). The large central section was built in 1887 to house the new Bon Marché Dry Goods store. The addition on the left side (matching the original right side building) was built in 1927.In the manner of the day, wares were sold outside on the street. Customers included the workers of the city's many textile mills. The store was on Merrimack Street in the heart of the commercial district of what was then the prosperous and growing city of Lowell.Even in its early days, Bon Marché billed itself as the largest department store in New England. Their Rock Bottom Basement Store featured an actual rock, a large glacial erratic which the basement was built around. The store was an anchor of Lowell's mercantile downtown. Its fortunes declined with the city as the mills closed. The last day of business was January 10, 1976. The building was taken over by the Jordan Marsh chain, which itself became defunct in 1996; the building now houses the UMass Lowell bookstore and other businesses.

Lowell National Historical Park is a National Historical Park of the United States located in Lowell, Massachusetts. Established in 1978 a few years after Lowell Heritage State Park, it is operated by the National Park Service and comprises a group of different sites in and around the city of Lowell related to the era of textile manufacturing in the city during the Industrial Revolution. In 2019, the park was included as Massachusetts' representative in the America the Beautiful Quarters series.

The Concord River is a 16.3-mile-long (26.2 km) tributary of the Merrimack River in eastern Massachusetts, United States. The river drains a small rural and suburban region northwest of Boston. As one of the most notable small rivers in U.S. history, it was the scene of an important early battle of the American Revolutionary War and was the subject of a 19th-century book by Henry David Thoreau.

The 1895 Lowell Post Office is an historic post office building at 89 Appleton Street in Lowell, Massachusetts. The imposing two-story granite building was completed in 1895 to a design by W. J. Edbrooke. The building has an H shape, and has a profusion of typical Richardsonian Romanesque features, included rounded arches over windows and a recessed entry. The focal point of the building is its five-story square clock tower, which is topped by a pyramidal roof supported by tripled round arches on each face.The building was used as a post office until 1936, when a new building on Kearney Square (now the F. Bradford Morse Federal Building) was put in service. The building continued to house federal offices until the 1970s, by which time its ownership had been transferred to the city. The city then used it for offices until the 1990s.The building was listed on the National Register of Historic Places in 2002. It now houses a division of the Middlesex County juvenile court system.

Saints Medical Center, a hospital, has been called "Lowell General - Saints Campus," since 2012 when it became a part of Lowell General Hospital. The campus is located at One Hospital Drive in Lowell, Massachusetts.The hospital was created out of a 1992 merger of two of the three hospitals in the city, St. Joseph's Hospital founded in 1839 and St. John's Hospital founded in 1867. The name changed to "Saints Medical Center" in 2006.In 2010 The hospital was renamed from Saints Memorial Medical Center to Saints Medical Center. On July 1, 2012 Saints merged with Lowell General Hospital. Several Saints satellite facilities have been reconfigured or cut back following the merger. In spring 2023, Saints Medical Centre received a B grading according to hospital safety grades.

The Colburn School is a historic former school building at 136 Lawrence Street in Lowell, Massachusetts, USA. Built in 1848, it is a fine example of institutional Greek Revival architecture, and is one of the city's older surviving school buildings, built during the rapid population growth that followed the city's industrialization. Now converted to apartments, it was listed on the National Register of Historic Places in 1995.