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99th Street was a local station on the demolished IRT Second Avenue Line in Manhattan, New York City. It had three tracks and two side platforms. The next stop to the north was 105th Street. The next stop to the south was 92nd Street. The station closed on June 11, 1940. Three blocks to the south mass transit service was replaced by the 96th Street station of the Second Avenue Subway.

99th Street was a local station on the demolished IRT Third Avenue Line in Manhattan, New York City. The station was originally built by the Manhattan Railway Company on December 30, 1878, and later had two levels. The lower level serving local trains was built first, and had two tracks and two side platforms. The upper level, built as part of the Dual Contracts had one track that bypassed the station and served express trains. This station closed on May 12, 1955, with the ending of all service on the Third Avenue El south of 149th Street. South of the station were connecting tracks to the 98th Street Yard. The station was also located next to Substation 7 an old IRT substation designed not only in order to electrify the Third Avenue Line, but the Second and Ninth Avenue elevated lines as well. Later it even served as a power source for the IRT Lexington Avenue Line from 1918 until the 1970s. The substation is still owned by the MTA and has been listed on the National Register of Historic Places since February 9, 2006.

The Church of the Holy Agony was a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located at 1834 Third Avenue and 101st Street, in the East Harlem section of Manhattan, New York City. The parish was established in 1930 as a mission of Our Lady of the Miraculous Medal. The parish is staffed by the Vincentian Fathers. In November 2014, the Archdiocese announced that the Church of the Holy Agony was one of 31 neighborhood parishes which would be merged into other parishes. Holy Agony was to be merged into the Church of St. Cecilia at 125 East 105th Street.The church was deconsecrated on June 30, 2017.

Substation 7 is a traction substation located at 1782 Third Avenue at 99th Street in the East Harlem neighborhood of Manhattan. The Manhattan Railway Company built it in order to electrify the Second, Third and Ninth Avenue elevated lines. It served as a power source for the IRT Lexington Avenue Line from 1918 until the 1970s. It originally converted 25 Hz AC power from the 74th Street power station, to DC for the electric motors. The substation is owned by the MTA and it is listed on the National Register of Historic Places.

The Islamic Cultural Center of New York is a mosque and an Islamic cultural center in East Harlem, Manhattan, New York City, United States. It is located at 1711 Third Avenue, between East 96th and 97th Streets. The Islamic Cultural Center was the first purpose-built mosque in New York and continues to be one of the city's largest. The mosque's older dwelling in a townhouse at 1 Riverside Drive is still in continual prayer use as a satellite location. The Islamic Cultural Center of New York is a standing building that is 61 meters wide and 73 meters long. The mosque is located at East 96th Street and 3rd Avenue on Manhattan's Upper East Side. When looking at it, the mosque is rotated 29 degrees towards the streets. The architects did this to portray the Turkish mosque and complete two goals. Those two goals were to stand out from its surroundings, and the mihrab can face Mecca, where it is the direction to pray towards the Kaaba.

Metropolitan Hospital Center (MHC, also referred to as Metropolitan Hospital) is a hospital in East Harlem, New York City. It has been affiliated with New York Medical College since it was founded in 1875, representing the oldest partnership between a hospital and a private medical school in the United States.MHC is part of the New York City Health and Hospitals Corporation (HHC), the largest municipal hospital and healthcare system in the country.

The 96th Street station is a station on the IND Second Avenue Line of the New York City Subway. Located at the intersection of Second Avenue and 96th Street on the border of the Upper East Side/Yorkville and East Harlem neighborhoods in Manhattan, it is the northern terminus for the Q train at all times. It is also served by limited southbound rush hour N trains and one northbound morning rush hour R train. The station is the terminus for the first phase of the Second Avenue Line. The station was not originally proposed as part of the Program for Action in 1968, but a later revision to that plan entailed building a Second Avenue Subway with one of its stops located at 96th Street. Construction on that project started in 1972, but stalled in 1975 due to lack of funding. In 2007, a separate measure authorized a first phase of the Second Avenue Line to be built between 65th and 105th Streets, with stations at 72nd Street, 86th Street and 96th Street. The station opened on January 1, 2017, as a terminal station, with provisions to extend the line north to Harlem–125th Street in Phase 2. Since opening, the presence of the Second Avenue Subway's three Phase 1 stations has improved real estate prices along the corridor. The 96th Street station was used by approximately 5.45 million passengers in 2017. The station, along with the other Phase 1 stations along the Second Avenue Subway, contains features not found in most New York City Subway stations. It is fully compliant with the Americans with Disabilities Act of 1990, containing two elevators for disabled access. Additionally, the station contains air conditioning and is waterproofed, a feature only found in newer stations. The artwork at 96th Street is "Blueprint for a Landscape", a mural by Sarah Sze.

Duffy's Hill is a hill located on Lexington Avenue between 102nd and 103rd Streets in the East Harlem neighborhood of Manhattan, New York City. It was named for Michael James Duffy, a Tammany Hall Alderman who spent $250,000 to build 26 rowhouses on the south side of 101st Street between Lexington and Park Avenues in 1894. He continued building between Third Avenue and Lexington Avenue up to 104th Street, a section of the city sometimes known at the time as "Duffyville".The hill marked the site of cable car accidents by 1897, as the cars had to quickly accelerate and decelerate at this point. The New York Railways Corporation had a 24-hour guard stationed at the base of the hill at 103rd Street by 1937 to watch over streetcar incidents related to the hill. At one time, Lexington Avenue buses would detour onto Park Avenue to avoid the hill.The National Board of Fire Underwriters noted that Lexington Avenue's grade of 12.6% was the steepest of any "important localit[y]" in Manhattan. The entrances to the 103rd Street station of the New York City Subway, served by the 6 and <6>​ trains, are located at the bottom of the hill.

The Lexington Avenue explosion was the July 4, 1914, explosion of a terrorist bomb in an apartment at 1626 Lexington Avenue in New York City. Members of the Lettish section of the Anarchist Black Cross (ABC) were constructing a bomb in a seven-story tenement when the group's large supply of dynamite exploded prematurely. The blast destroyed most of the top three floors of the building, killing three conspirators and another renter who was not part of the bomb plot, as well as injuring dozens more.

The 103rd Street station is a local station on the IRT Lexington Avenue Line of the New York City Subway. Located at the intersection of Lexington Avenue and 103rd Street in East Harlem, it is served by the 6 train at all times, the <6> train during weekdays in the peak direction, and the 4 train during late nights. This station was constructed as part of the Dual Contracts by the Interborough Rapid Transit Company and opened in 1918. It was renovated in 1990 and in 2015-2016.

The 28th Police Precinct Station is a former New York City Police Department (NYPD) police station at 177–179 East 104th Street in the East Harlem neighborhood of Manhattan, New York City, United States. Built between 1892 and 1893, it served the 28th (later 23rd) Precinct of the NYPD until 1974. It was designed by Nathaniel D. Bush in the Rundbogenstil, Renaissance Revival, and Neo-Grec styles as one of ten NYPD station houses he designed in Manhattan. Since 1981 it has been owned by the Hope Community Hall of Hope Community Inc, a non-profit housing organization. The building has a symmetrical five-story red brick facade with granite decorations, divided into a tall central bay and two shorter bays flanking it. Inside, there were originally public-facing staff offices on the ground floor, and dormitories and sergeants' offices on the upper stories. There is also a two-story rear annex, which was once used as a jail and a homeless shelter. The building is listed on the National Register of Historic Places and is preserved by the New York City Landmarks Preservation Commission as an individual city landmark.

The Metro North Plaza Houses are a public housing project owned by the New York City Housing Authority (NYCHA). The housing complex is located between 1st and 2nd Avenues and East 101st and 102nd Streets in the Spanish Harlem part of the East Harlem neighborhood of Manhattan in New York. It has three buildings. Building I has 7 floors, Building II has 11 floors, and Building III has 8 floors.