MaRS Discovery District

The McEwen Centre for Regenerative Medicine was established at University Health Network in Toronto in 2003, with a donation from Rob and Cheryl McEwen, which they matched in 2006 with a second donation. The McEwen Centre's vision is to be a world-renowned centre for stem cell biology and regenerative medicine. To achieve this ambitious goal, the team of McEwen Investigators is working together to accelerate the development of more effective treatments for conditions such as heart disease, diabetes mellitus, respiratory disease and spinal cord injury. The McEwen Centre is based in the heart of Toronto's Discovery District at the MaRS Centre/Toronto Medical Discovery Tower. The current Director of the McEwen Center for Regenerative Medicine is Prof. Gordon Keller, Canada Research Chair in Embryonic Stem Cell Biology.

The Ontario Institute for Cancer Research (OICR) is a not-for-profit organization based in Toronto, Ontario, Canada that focuses on the prevention, early detection, diagnosis and treatment of cancer. OICR intends to make Ontario more effective in knowledge transfer and commercialization while maximizing the health and economic benefits of research findings for the people of Ontario. OICR was launched in 2005 by the Government of Ontario, which provides funding through the Ministry of Colleges and Universities. The Institute employs more than 300 people at its research hub at the MaRS Centre in downtown Toronto and funds more than 1,900 scientific staff at hospital-based research institutes and universities around the province. In 2018 it was the highest funder of cancer research in Canada.

The Toronto General Hospital (TGH) is a major teaching hospital in Toronto, Ontario, Canada and the flagship campus of University Health Network (UHN). It is located in the Discovery District of Downtown Toronto along University Avenue's Hospital Row; it is directly north of The Hospital for Sick Children, across Gerrard Street West, and east of Princess Margaret Cancer Centre and Mount Sinai Hospital. The hospital serves as a teaching hospital for the University of Toronto Faculty of Medicine. In 2019, the hospital was ranked first for research in Canada by Research Infosource for the ninth consecutive year.The emergency department now treats 28,065 persons each year, while the hospital also houses the major transplantation service for Ontario, performing heart, lung, kidney, liver, pancreas, and small intestine, amongst others, for patients referred from all over Canada. The hospital is the largest organ transplant center in North America, performing 639 transplants in 2017. The hospital is also renowned for cardiac and thoracic surgery. The world's first single and double lung transplants were performed at TGH in 1983 and 1986 and the world's first valve-sparing aortic root replacement was done by Tirone David at Toronto General Hospital in 1992. The Lung Transplant program is currently the largest in the world, performing 167 lung transplants in 2017. In 2015, surgeons performed the world's first triple organ transplant (lung, liver and pancreas) in 19 year old Reid Wylie at Toronto General Hospital. TGH teaches resident physicians, nurses, and technicians; it also conducts research through the Toronto General Research Institute. Currently, Sophie, Duchess of Edinburgh, as a member of the Canadian Royal Family, is patron of the hospital.

The Ontario Firefighters Memorial is a monument in Toronto's Queen's Park, in Ontario, Canada.

The Frost Building is a curved 7 and 6 storey office building complex on the south east side of Queen's Park Crescent in Toronto, Ontario, Canada. The building is owned by the Government of Ontario and is part of the large Queen's Park campus. The Frost Building is home to various ministries of the Ontario government, primarily the Ministries of Finance and Treasury Board Secretariat. It is divided into a north block (6 storey building was home, in 2014, to parts of the Ministry of Finance and Ministry of Infrastructure) and a south block (7 storey), with the north block located on 95 Grosvenor Street and the south block located on 7 Queen's Park Crescent. A five-storey glass walkway connects the two blocks from the 2nd and 6th floors. The building is named after Leslie Frost, Premier of Ontario for more than a decade starting in 1949. The Frost Building is also commonly referred to as the Ontario Treasury Building. The south block of the building has seven floors; the top floor housing the Office of the Minister of Finance and the Office of the Deputy Minister of Finance. The current Finance Minister of Ontario is Peter Bethlenfalvy and the Deputy Minister of Finance is Greg Orencsak. The building is a landmark of modern office building architecture in Canada, dating from the early 1950s. It was one of the first totally "modern look" buildings without any of the fancy curlicues of older buildings. It was also original in that it follows the curve of the street on which it resides. It is named for former Premier of Ontario Leslie Frost. The north block was built in the 1960s as an addition to the South Block. The Ontario Firefighters' Memorial is located in a small parkette to the southwest corner of the building. Other government buildings nearby include: Ontario Government Buildings - Hearst, Mowat and Hepburn Blocks Whitney Block Ontario Power Building - shares the curve building design with the Frost BuildingThe building is served by the Queen's Park (TTC) subway station to the southwest corner.

Queen's Park is a subway station on Line 1 Yonge–University in Toronto, Ontario, Canada. The station, which opened in 1963, is located under University Avenue at College Street. The station is wheelchair-accessible and has had underground connections to adjoining buildings since 2002. Wi-Fi service is available at this station.

The Discovery District is one of the commercial districts in Downtown Toronto, Ontario, Canada. It has a high concentration of hospitals and research institutions, particularly those related to biotechnology. The district is roughly bounded by Bloor Street on the north, Bay Street on the east, Dundas Street on the south, and Spadina Avenue on the west.

Victoria Hospital for Sick Children is a building in Toronto, Ontario, Canada. The building served as a hospital until 1951 and currently serves as a blood centre. The building has received a Commendation of Adaptive Re-use from the Toronto Historical Board.

A statue of John A. Macdonald by Hamilton MacCarthy is installed in Toronto's Queen's Park, in Ontario, Canada. The sculpture was unveiled in 1894.

Notre Place Monument, also known as Notre place (English: Our Home), is a monument in Toronto's Queen's Park, in Ontario, Canada. Unveiled in 2018, the monument features a public space and a series of columns.

The Northwest Rebellion Monument is a memorial installed in Toronto's Queen's Park, in Ontario, Canada.

The Princess Margaret Cancer Centre (previously, Princess Margaret Hospital) is a scientific research centre and a teaching hospital in Toronto, Ontario, Canada, affiliated with the University of Toronto Faculty of Medicine as part of the University Health Network. The hospital now stands as the largest cancer centre in Canada and one of the five largest cancer centres in the world. Along with the Odette Cancer Centre, which is also associated with University of Toronto Faculty of Medicine and is independently the sixth largest cancer centre in North America, it forms one of the largest cluster of cancer hospitals in the world.The hospital is situated near the intersection of University Avenue and College Street within the Discovery District of downtown Toronto, an area with high concentration of biomedical research institutions. Named for Princess Margaret, Countess of Snowdon, the hospital is under the royal patronage of Anne, Princess Royal. The hospital specializes in the treatment of cancer, and offers the majority of its services to residents of the Greater Toronto Area. The hospital offers expertise in the fields of surgical oncology, medical oncology, hematology including bone marrow transplantation, radiation oncology, psychosocial oncology, medical imaging, and radiation therapy. The hospital houses 17 radiation treatment machines, all of which are equipped with the latest technologies including IMRT and VMAT, a superficial orthovoltage machine, and operates a Gamma Knife (Perfexion) stereotactic radiosurgery machine in collaboration with Toronto Western Hospital.