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Astor Row is the name given to 28 row houses on the south side of West 130th Street, between Fifth and Lenox Avenues in the Harlem neighborhood of Manhattan, New York City, which were among the first speculative townhouses built in the area. Designed by Charles Buek, the houses were built between 1880 and 1883 in three spurts, on land John Jacob Astor had purchased in 1844 for $10,000. Astor's grandson, William Backhouse Astor, Jr., was the driving force behind the development. The design of the three-story brick, single-family houses is unusual, in that they are set back from the street, and all have front and side yards – an oddity in Manhattan – as well as wooden porches. The first group of houses, numbers 8 through 22, comprises freestanding pairs, while the remainder, numbers 24 through 60, are connected together at the rear.The Astor Row houses were designated New York City Landmarks on August 11, 1981.

Sylvia's Restaurant of Harlem, often called Sylvia's Soul Food or just Sylvia's, is a soul food restaurant located at 328 Lenox Avenue, between 126th and 127th Streets, in Harlem, Manhattan, New York City. It was founded in 1962 by Sylvia Woods. It has since expanded to a much larger space at its present location, and an adjacent building. The restaurant also sells a line of prepared foods, beauty and skin care items, cookbooks, and a children's book written by Woods. Woods purchased the original luncheonette by borrowing money from her mother, who had to mortgage her farm to provide it. The restaurant attracts a clientele that ranges from Harlem locals to visiting celebrities. Whoopi Goldberg, Bill Clinton, Nelson Mandela, Caroline Kennedy, Jesse Jackson, Al Sharpton, Magic Johnson, Barack Obama, Bernie Sanders and Bruno Mars are among those who have dined there. Sylvia's was also featured on a Manhattan-themed episode of the Travel Channel's Man v. Food in early 2009. On September 19, 2007, commentator Bill O'Reilly received criticism regarding comments he made on his syndicated radio show, about having lunch at Sylvia's with Al Sharpton. O'Reilly concluded that stereotypes regarding African Americans were not true based on observations he had made at the restaurant.In response to the COVID-19 pandemic, Sylvia's Restaurant participated in relief efforts by donating fifty meals to Harlem Hospital. The restaurant announced plans to open a pop-up pantry featuring meal kits to serve the community.

The Metropolitan Baptist Church, located at 151 West 128th Street on the corner of Adam Clayton Powell Jr. Boulevard in the Harlem neighborhood of Manhattan, New York City, was originally built in two sections for the New York Presbyterian Church, which moved to the new building from 167 West 111th Street. The chapel and lecture room were built in 1884-85 and were designed by John Rochester Thomas, while the main sanctuary was constructed in 1889-90 and was designed by Richard R. Davis, perhaps following Thomas's unused design. A planned corner tower was never built.In 1918, the church was acquired by the Metropolitan Baptist Church, a congregation founded in 1912 which was one of the first African American congregations in Harlem. They moved to this building from the Metropolitan Baptist Tabernacle at 120 West 138th Street, which later became Liberty Hall, a focus of the Back-to-Africa movement.The church was designated a New York City Landmark in 1981, and was listed on the National Register of Historic Places in 1982.

The Hoofers Club was an African-American entertainment establishment and dancers' club hangout in Harlem, New York, that ran from the early 1920s until the early 1940s. It was founded and managed by Lonnie Hicks (1882–1953), an Atlanta-born ragtime pianist.

Connie's Inn was a Harlem, New York City, black and tan nightclub established in 1923 by Connie Immerman (né Conrad Immerman; 1893–1967) in partnership with two of his brothers, George (1884–1944) and Louie Immerman (1882–1955).

Park and Tilford Building is a historic commercial building located at 310 Lenox Avenue in Harlem, Manhattan, New York City.

The Lafayette Theatre (1912–1951), known locally as "the House Beautiful", was one of the most famous theaters in Harlem. It was an entertainment venue located at 132nd Street and 7th Avenue in Harlem, New York. The structure was demolished in 2013.

St. Andrew's Episcopal Church is a historic Episcopal church located at 2067 Fifth Avenue at 127th Street in the neighborhood of Harlem in Manhattan, New York City. Built in 1872, it was designed by noted New York City architect Henry M. Congdon (1834–1922) in the Gothic Revival style. It features a 125 foot tall clock tower surmounted by a slate covered spire surrounded by four towerlets.On March 18, 1980, it was added to the National Register of Historic Places. The church was designated as a city landmark by the New York City Landmarks Preservation Commission in 1967. It is still an active parish in the Episcopal Diocese of New York.In 2020, it reported 138 members, average attendance of 32, and $192,540 in plate and pledge income.

133rd Street is a street in Manhattan and the Bronx, New York City. In Harlem, Manhattan, it begins at Riverside Drive on its western side and crosses Broadway, Amsterdam Avenue, and ends at Convent Avenue, before resuming on the eastern side, crossing Seventh Avenue, and ending at Lenox Avenue. In Port Morris in the Bronx, it runs from Bruckner Boulevard/St. Ann's Place to Locust Avenue. The block between Seventh Avenue and Lenox Avenues was once a thriving night spot, known as "Swing Street", with numerous cabarets, jazz clubs, and speakeasies. The street is described in modern times as "a quiet stretch of brownstones and tenement-style apartment houses, the kind of block that typifies this section of central Harlem".

Homer Lusk Collyer (November 6, 1881 – March 21, 1947) and Langley Wakeman Collyer (October 3, 1885 – c. March 9, 1947), known as the Collyer brothers, were two American brothers who became infamous for their bizarre natures and compulsive hoarding. The two lived in seclusion in their Harlem brownstone at 2078 Fifth Avenue (at the corner of 128th Street) in New York City where they obsessively collected books, furniture, musical instruments, and myriad other items, with booby traps set up in corridors and doorways to crush intruders. Both died in their home in March 1947 and were found dead (Homer on March 21, Langley not until April 8) surrounded by more than 140 tons of collected items that they had amassed over several decades.Since the 1960s, the site of the former Collyer house has been a pocket park, named for the brothers.

The St. Aloysius Catholic Church is a Catholic parish in the Archdiocese of New York, located at 209-217 West 132nd Street between Adam Clayton Powell Jr. Boulevard and Frederick Douglass Boulevard in the Harlem neighborhood of Manhattan, New York City. It was built in 1902-04 and was designed by William W. Renwick – the nephew of James Renwick Jr. – in the Italian Gothic Revival style. It has been called a "little-known treasure". The church was designated a New York City Landmark on January 30, 2007.

Lenox Lounge was a long-standing bar in Harlem, New York City. It was located in 288 Lenox Avenue, between 124th and 125th. The bar was founded in 1939 by Ralph Greco and served as a venue for performances by many great jazz artists, including Billie Holiday, Miles Davis, and John Coltrane. Harlem Renaissance writers James Baldwin and Langston Hughes were both patrons, as was Malcolm X.The bar deteriorated through the middle of the 20th century. Alvin Reid, Sr. purchased it in 1988 and restored the original Art Deco interior from September 1999 to March 2000, during the only closure in the bar's history.The Lenox Lounge was voted "Best of the Best" by the 2002 Zagat Survey Nightlife Guide and by the 2001 New York Magazine. In 2012, a rent increase threatened to shutter the establishment. In December 2012, it was announced that it would close at the end of the year. However in January 2013 Reid said he was reopening at 333 Lenox Avenue and that it would have its iconic neon sign there. Richard Notar, who owned the Nobu Restaurant chain and who took over the lease on the original 288 Lenox location, said he would maintain the decor of the original 288 lounge which does not yet have a name. In May 2017 the building was demolished. The Zebra Room was used for a key scene in the Mad Men pilot, "Smoke Gets In Your Eyes".