E. R. Meres Sponge Packing House

The Safford House is a historic home in Tarpon Springs, Florida. On October 16, 1974, it was added to the U.S. National Register of Historic Places. The house is named for its original owner, Anson P.K. Safford. The city of Tarpon Springs owns and operates the Safford House Museum as a late 19th-century Victorian historic house museum.

The following buildings were added to the National Register of Historic Places as part of the Tarpon Springs Sponge Boats Multiple Property Submission (or MPS).

The N. G. Arfaras Sponge Packing House is a historic site in Tarpon Springs, Florida. It is located at 26 West Park Street. On April 10, 1991, it was added to the U.S. National Register of Historic Places.

St. Nicholas Greek Orthodox Cathedral is a Greek Orthodox parish and center for Greek-American life in Tarpon Springs, Florida. Its noted Neo-Byzantine church is located at 36 North Pinellas Avenue.St. Nicholas hosts an annual Epiphany celebration on January 6, in which Greek Orthodox boys aged 16 to 18 dive into Spring Bayou to retrieve a white wooden cross, said to bring the finder blessings for the year. It is the largest such event in the Western Hemisphere, with thousands in attendance. A statue of an epiphany diver is located in front of the church.

The St. Nicholas III is a historic boat in Tarpon Springs, Florida. It is located at the Tarpon Springs Sponge Docks at Dodecanese Boulevard. On August 3, 1990, it was added to the U.S. National Register of Historic Places.

The Tarpon Springs Historic District is a U.S. historic district in Tarpon Springs, Florida. It is bounded by Read Street, Hibiscus Street, Orange Street, Levis Avenue, Lemon Street and Spring Bayou, encompasses approximately 700 acres (2.8 km2), and contains 145 historic buildings. On December 6, 1990, it was added to the U.S. National Register of Historic Places.

Located in north Pinellas County, Florida, approximately thirty miles northwest of Tampa, Tarpon Springs Greektown Historic District is a U.S. historic district. It was added to the National Register of Historic Places on June 2, 2014.Tarpon Springs’ Greektown District is a traditional cultural property that preserves a strong ethnic and maritime character. The District measures about 140 acres. The primary area is bounded by the Anclote River on the north, Tarpon Avenue and Spring Bayou on the south, Hibiscus and Pinellas Streets on the east; and Roosevelt and Grand Boulevards to Spring Bayou on the west—see the maps and inventory for details. The architectural resources have historic integrity. They convey a distinctive sense of place and ethnic heritage, with commercial, industrial, residential, and religion-based buildings as well as boats, generally developed without the benefit of architectural plans. The Greektown District was the first Traditional Cultural Property listed in the State of Florida.

The Tarpon Springs Cultural Center includes the Center for Gulf Coast Folklife and located in Tarpon Springs, Florida at 101 South Pinellas Avenue in Old Tarpon Springs City Hall.

Built in 1915, the Old Tarpon Springs City Hall is a historic site in Tarpon Springs, Florida. It is located at 101 South Pinellas Avenue. On August 10, 1990, it was added to the U.S. National Register of Historic Places. It was designed by renowned architect Ernest Ivey Cook in the neoclassical style.

The Arcade Hotel (also known as the Shaw Arcade or Howard Hotel) is a historic hotel in Tarpon Springs, Florida, United States. It is located at 210 South Pinellas Avenue. On January 12, 1984, it was added to the U.S. National Register of Historic Places. Several guests had stayed there throughout the 1930s and committed suicide in the hotel after Black Tuesday, the beginning of the Great Depression. The building now houses several shop. It is located on alt. 19 in Tarpon Springs Florida, near the historic downtown.

The Duchess is a historic sponge-hooking boat in Tarpon Springs, Florida. It is located at the Tarpon Springs Sponge Docks at Dodecanese Boulevard. On August 2, 1990, it was added to the U.S. National Register of Historic Places.

The N. K. Symi (also known as the Eleni) is a historic boat in Tarpon Springs, Florida. It is located at the Tarpon Springs Sponge Docks at Dodecanese Boulevard. On August 2, 1990, it was added to the U.S. National Register of Historic Places.